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Impact of Chaperonopathies in Protein Homeostasis and Beyond

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The Chaperonopathies

Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology ((BRIEFSBIOCHEM))

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Abstract

Chaperones have functions other than those classically attributed to them pertaining to protein homeostasis. These “other” non-canonical functions are the focus of chapter 8. The close interaction of the chaperoning and the immune systems and the impact of their malfunctioning on aging and cancer are highlighted. Conversely, the impact of ageing and cancer on the two systems is also underscored. The connections between stress, protein damage (including chaperones), protein misfolding, protein aggregation and precipitation, and tissue degeneration, are analyzed, indicating that all these processes are aggravated by a decline in chaperoning potential with aging (chaperonopathies of the aged) and the progression of certain pathologic conditions. Again, the potential of chaperonotherapy in these chaperonopathies is mentioned as a worthy aim in future research.

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Further Reading

IMPACT OF CHAPERONOPATHIES IN PROTEIN HOMEOSTASIS AND BEYOND For Further Reading see also Chaps. 6 and 7 Hsp60 Helps (Mistakenly?) in the Accumulation of Pathological Proteins Inside Mitochondria, Disrupting Mitochondrial Functions

  • Walls KC, Coskun P, Gallegos-Perez JL, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green KN, Laferla FM (2012) Swedish Alzheimer’s mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of APP and beta-amyloid. J Biol Chem 287:30317–3027

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Authors and Affiliations

  1. Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA

    Alberto J.L Macario & Everly Conway de Macario

  2. Istituto EuroMediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy

    Alberto J.L Macario

  3. Institute of Marine and Environmental Technology (IMET), Columbus Center, 701 East Pratt Street, Baltimore, MD, 21202, USA

    Alberto J.L Macario & Everly Conway de Macario

  4. Sezione di Anatomia Umana, Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Università degli Studi di Palermo, via del Vespro 129, Palermo, 90127, Italy

    Francesco Cappello

  5. Istituto EuroMediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy

    Francesco Cappello

Authors
  1. Alberto J.L Macario
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  2. Everly Conway de Macario
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  3. Francesco Cappello
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Correspondence to Alberto J.L Macario .

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Macario, A.J., Conway de Macario, E., Cappello, F. (2013). Impact of Chaperonopathies in Protein Homeostasis and Beyond. In: The Chaperonopathies. SpringerBriefs in Biochemistry and Molecular Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4667-1_8

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