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Reprogramming: A New Era in Regenerative Medicine

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Induced Pluripotent Stem Cells in Brain Diseases

Part of the book series: SpringerBriefs in Neuroscience ((BRIEFSNEUROSCI))

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Abstract

Embryonic stem cells (ESCs) exhibit the capacity for unlimited self-renewal and an ability to generate all somatic cell lines. However, political, ethical and practical obstacles, such as rejection of ESC-derived tissue by patients, obstruct the potential for using human ESCs (hESCs) in regenerative medicine. Still, the extreme plasticity and proliferative nature of ESCs make them the ‘gold standard’ to match or beat. While some reprogramming technologies, such as somatic cell nuclear transfer (SCNT) , are capable of generating ESC-like states they face similar challenges associated with ESCs. In 2006, Takahashi and Yamanaka reported the development of so-called “induced pluripotent stem cells” (iPSCs) from adult mouse fibroblasts. These cells were produced by inducing the expression of four transcription factors (TFs). In the last few years, many alternative reprogramming strategies have been studied in order to develop a safe and efficient method for therapeutic applications.

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  1. Judith Wagner

    Present address: Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, 80336, Munich, Germany

Authors and Affiliations

  1. Center for Children with White Matter Disorders, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    Vivi M. Heine, Stephanie Dooves & Dwayne Holmes

  2. Clinical Genetics, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands

    Judith Wagner

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  1. Vivi M. Heine
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  2. Stephanie Dooves
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Correspondence to Vivi M. Heine .

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Heine, V.M., Dooves, S., Holmes, D., Wagner, J. (2012). Reprogramming: A New Era in Regenerative Medicine. In: Induced Pluripotent Stem Cells in Brain Diseases. SpringerBriefs in Neuroscience. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2816-5_1

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