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Induced Pluripotent Stem Cells in Brain Diseases

Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine.

  • Vivi M. Heine
  • Stephanie Dooves
  • Dwayne Holmes
  • Judith Wagner

Part of the SpringerBriefs in Neuroscience book series (BRIEFSNEUROSCI)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner
    Pages 1-25
  3. Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner
    Pages 27-41
  4. Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner
    Pages 43-54
  5. Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner
    Pages 55-59

About this book

Introduction

The principle goal of regenerative medicine is the restoration of damaged, dysfunctional, or missing cellular tissue, up to and including whole organs. Growing healthy replacement tissue, in vivo or in vitro, plays an important role in anticipated therapies. To generate competent replacement material, scientists confront the fundamental issues of cellular identity and plasticity.

The basis of this book is formed by the theses of three talented master students: Stephanie Dooves, Dwayne Holmes and Judith Wagner. Their work discusses the recent advancements in the field of cell reprogramming. Although it is clear that we can produce pluripotent stem cells from differentiated cells, there are still a lot of unsolved issues. These issues include the efficiency and safety of reprogramming, the similarity of induced pluripotent (iPSCs) to embryonic stem cells (ESCs) and the epigenetic status of the cells. In the third chapter, the use of stem cell therapy for brain diseases will be discussed, with a focus on Parkinson’s disease (PD) and Vanishing White Matter (VWM).

Keywords

epigenetics induced pluripotent stem cell neurology regenerative medicine

Authors and affiliations

  • Vivi M. Heine
    • 1
  • Stephanie Dooves
    • 2
  • Dwayne Holmes
    • 3
  • Judith Wagner
    • 4
  1. 1., Child NeurologyVU University Medical CenterAmsterdamNetherlands
  2. 2., White Matter DisordersVU University Medical CenterAnsterdamNetherlands
  3. 3., White Matter DisordersVU University Medical CenterAmsterdamNetherlands
  4. 4., Clinical GeneticsVU University Medical CenterAmsterdamNetherlands

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-2816-5
  • Copyright Information The Author(s) 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-2815-8
  • Online ISBN 978-94-007-2816-5
  • Series Print ISSN 2191-558X
  • Series Online ISSN 2191-5598
  • Buy this book on publisher's site