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Spatial and Temporal Aspects of Radiation Response in Cell and Tissue Models

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Radiation Damage in Biomolecular Systems

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Rapid advances in our understanding of radiation responses, at the subcellular, cellular, tissue and whole body levels have been driven by the advent of new technological approaches for radiation delivery. Ionising radiation microbeams allow precise doses of radiation to be delivered with high spatial accuracy. They have evolved through recent advances in imaging, software and beam delivery to be used in a range of experimental studies probing spatial, temporal and low dose aspects of radiation response. A range of microbeams have been developed worldwide which include ones capable of delivering charged particles, X-rays and electrons. The original rational for their development was as a precise means of measuring the effects of single radiation tracks. However, the ability to target radiation with microbeams at subcellular targets has been used to address fundamental questions related to radiosensitive sites within cells. Further developments include using microbeams to target more complex 3-D systems where the possibilities of utilizing the unique characteristics of microbeams in terms of their spatial and temporal delivery will make a major impact.

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References

  1. G. Schettino, S.T. Al Rashid, K.M. Prise, Mutat Res 704 (2010) 68–77

    Article  Google Scholar 

  2. D.J. Brenner, R.C. Miller, Y. Huang, E.J. Hall, Radiat. Res. 142 (1995) 61–69

    Article  Google Scholar 

  3. M.A. Kadhim, S.A. Lorimore, K.M. Townsend, D.T. Goodhead, V.J. Buckle, E.G. Wright, International Journal of Radiation Biology 67 (1995) 287–293

    Article  Google Scholar 

  4. B. Marples, M.C. Joiner, Radiation Research 133 (1993) 41–51

    Article  Google Scholar 

  5. K.M. Prise, G. Schettino, M. Folkard, K.D. Held, Lancet Oncol 6 (2005) 520–528

    Article  Google Scholar 

  6. K.M. Prise, J.M. O’Sullivan, Nat Rev Cancer 9 (2009) 351–360

    Article  Google Scholar 

  7. D.R. Boreham, J.-A. Dolling, J. Broome, S.R. Maves, B.P. Smith, R.E.J. Mitchel, Radiation Research 153 (2000) 230–231

    Google Scholar 

  8. R.C. Miller, G. Randers-Pehrson, C.R. Geard, E.J. Hall, D.J. Brenner, Proc Natl Acad Sci USA 96 (1999) 19–22

    Article  ADS  Google Scholar 

  9. K.M. Prise, M. Folkard, A.M. Malcolmson, C.H. Pullar, G. Schettino, A.G. Bowey, B.D. Michael, Adv Space Res 25 (2000) 2095–2101

    Article  ADS  Google Scholar 

  10. M.A. Kadhim, S.J. Marsden, D.T. Goodhead, A.M. Malcolmson, M. Folkard, K.M. Prise, B.D. Michael, Radiat Res 155 (2001) 122–126

    Article  Google Scholar 

  11. S. Chahotin, Biol Zent. 32 (1912) 623

    Google Scholar 

  12. S. Gerardi, J. Radiat Res 50 (2010) A15–A30

    Google Scholar 

  13. R.E. Zirkle, W. Bloom, Science 117 (1953) 487–493

    Article  ADS  Google Scholar 

  14. M. Folkard, K.M. Prise, G. Schettino, C. Shao, S. Gilchrist, B. Vojnovic, Nuclear Instruments and Methods B 231 (2005) 189–194

    Article  ADS  Google Scholar 

  15. G. Randers-Pehrson, C. Geard, G. Johnson, D. Brenner, Radiation Research 153 (2000) 221–223

    Google Scholar 

  16. Y. Kobayashi, T. Funayama, S. Wada, Y. Furusawa, M. Aoki, C. Shao, Y. Yokota, T. Sakashita, Y. Matsumoto, T. Kakizaki, N. Hamada, Biol Sci Space 18 (2004) 235–240

    Article  Google Scholar 

  17. S. Gerardi, G. Galeazzi, R. Cherubini, Radiat Res 164 (2005) 586–590

    Article  Google Scholar 

  18. A. Hauptner, S. Dietzel, G.A. Drexler, P. Reichart, R. Krucken, T. Cremer, A.A. Friedl, G. Dollinger, Radiat Environ Biophys 42 (2004) 237–245

    Article  Google Scholar 

  19. A. Bigelow, G. Garty, T. Funayama, G. Randers-Pehrson, D. Brenner, C. Geard, J Radiat Res (Tokyo) 50 Suppl A (2009) A21–28

    Google Scholar 

  20. M. Heiss, B.E. Fischer, B. Jakob, C. Fournier, G. Becker, G. Taucher-Scholz, Radiat Res 165 (2006) 231–239

    Article  Google Scholar 

  21. K. Greif, W. Beverung, F. Langner, D. Frankenberg, A. Gellhaus, F. Banaz-Yasar, Radiat Prot Dosimetry 122 (2006) 313–315

    Article  Google Scholar 

  22. M. Heiss, B.E. Fischer, M. Cholewa, Radiation Research 161 (2004) 98–99

    Google Scholar 

  23. A. Fiedler, T. Reinert, J. Tanner, T. Butz, Nuclear Instruments and Methods in Physics Research B 260 (2007) 169–173

    Article  ADS  Google Scholar 

  24. H. Imaseki, T. Ishikawaa, H. Isoa, T. Konishia, N. Suyaa, T. Hamanoa, X. Wanga, N. Yasudaa, M. Yukawaa, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 260 (2007) 81–84

    Article  Google Scholar 

  25. M. Folkard, B. Vojnovic, K.J. Hollis, A.G. Bowey, S.J. Watts, G. Schettino, K.M. Prise, B.D. Michael, International Journal of Radiation Biology 72 (1997) 387–395

    Article  Google Scholar 

  26. G. Randers-Pehrson, C.R. Geard, G. Johnson, C.D. Elliston, D.J. Brenner, Radiat Res 156 (2001) 210–214

    Article  Google Scholar 

  27. M. Folkard, G. Schettino, B. Vojnovic, S. Gilchrist, A.G. Michette, S.J. Pfauntsch, K.M. Prise, B.D. Michael, Radiat Res 156 (2001) 796–804

    Article  Google Scholar 

  28. Y. Kobayashi, T. Funayama, N. Hamada, T. Sakashita, T. Konishi, H. Imaseki, K. Yasuda, M. Hatashita, K. Takagi, S. Hatori, K. Suzuki, M. Yamauchi, S. Yamashita, M. Tomita, M. Maeda, K. Kobayashi, N. Usami, L. Wu, J Radiat Res (Tokyo) 50 Suppl A (2009) A29–47

    Google Scholar 

  29. P.D. Prewett, A.G. Michette, in: A.K. Freund, T. Ishikawa, A.M. Khounsary, D.C. Mancini, A.G. Michette, S. Oestreich (Eds.), Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series, 2001, pp. 180–187

    Google Scholar 

  30. M.B. Sowa, M.K. Murphy, J.H. Miller, J.C. McDonald, D.J. Strom, G.A. Kimmel, Radiat Res 164 (2005) 695–700

    Article  Google Scholar 

  31. D.T. Goodhead, International Journal of Radiation Biology 56 (1989) 623–634

    Article  Google Scholar 

  32. T.J. Jenner, C.M. deLara, P. O’Neill, D.L. Stevens, International Journal of Radiation Biology. 64 (1993) 265–273

    Google Scholar 

  33. K.M. Prise, M. Pinto, H.C. Newman, B.D. Michael, Radiat Res 156 (2001) 572–576

    Article  Google Scholar 

  34. H.G. Paretzke, Adv Space Res 6 (1986) 67–73

    Article  ADS  Google Scholar 

  35. B. Grosswendt, S. Pszona Radiat Environ Biophys 41 (2002) 91–102

    Google Scholar 

  36. B. Jakob, M. Scholz, G. Taucher-Scholz, Radiat Res 159 (2003) 676–684

    Article  Google Scholar 

  37. H. Nikjoo, P. O’Neill, W.E. Wilson, D.T. Goodhead, Radiat Res 156 (2001) 577–583

    Article  Google Scholar 

  38. R.M. Anderson, D.L. Stevens, D.T. Goodhead, Proc Natl Acad Sci USA 99 (2002) 12167–12172

    Article  ADS  Google Scholar 

  39. B.E. Nelms, R.S. Maser, J.F. Mackay, M.G. Lagally, J.H.J. Petrini, Science 280 (1998) 590–592

    Article  ADS  Google Scholar 

  40. J. Essers, A.B. Houtsmuller, L. van Veelen, C. Paulusma, A.L. Nigg, A. Pastink, W. Vermeulen, J.H. Hoeijmakers, R. Kanaar, Embo J 21 (2002) 2030–2037

    Article  Google Scholar 

  41. J.A. Aten, J. Stap, P.M. Krawczyk, C.H. van Oven, R.A. Hoebe, J. Essers, R. Kanaar, Science 303 (2004) 92–95

    Article  ADS  Google Scholar 

  42. A. Asaithamby, N. Uematsu, A. Chatterjee, M.D. Story, S. Burma, D.J. Chen, Radiat Res 169 (2008) 437–446

    Article  Google Scholar 

  43. B. Jakob, J.H. Rudolph, N. Gueven, M.F. Lavin, G. Taucher-Scholz, Radiat Res 163 (2005) 681–690

    Article  Google Scholar 

  44. R.L. Warters, K.G. Hofer, Radiat Res 69 (1977) 348–358

    Article  Google Scholar 

  45. L.J. Wu, G. Randers-Pehrson, A. Xu, C.A. Waldren, C.R. Geard, Z. Yu, T.K. Hei, Proc Natl Acad Sci USA 96 (1999) 4959–4964

    Article  ADS  Google Scholar 

  46. C. Shao, M. Folkard, B.D. Michael, K.M. Prise, Proc Natl Acad Sci USA 101 (2004) 13495–13500

    Article  ADS  Google Scholar 

  47. H. Zhou, V.N. Ivanov, Y.C. Lien, M. Davidson, T.K. Hei, Cancer Res 68 (2008) 2233–2240

    Article  Google Scholar 

  48. S. Chen, Y. Zhao, W. Han, G. Zhao, L. Zhu, J. Wang, L. Bao, E. Jiang, A. Xu, T.K. Hei, Z. Yu, L. Wu, Br J Cancer 98 (2008) 1839–1844

    Article  Google Scholar 

  49. L. Tartier, S. Gilchrist, S. Burdak-Rothkamm, M. Folkard, K.M. Prise, Cancer Res 67 (2007) 5872–5879

    Article  Google Scholar 

  50. O.V. Belyakov, M. Folkard, C. Mothersill, K.M. Prise, B.D. Michael, Radiation Protection Dosimetry 99 (2002) 249–251

    Google Scholar 

  51. O.V. Belyakov, M. Folkard, C. Mothersill, K.M. Prise, B.D. Michael, Mutat Res 597 (2006) 43–49

    Article  Google Scholar 

  52. O.V. Belyakov, S.A. Mitchell, D. Parikh, G. Randers-Pehrson, S.A. Marino, S.A. Amundson, C.R. Geard, D.J. Brenner, Proc Natl Acad Sci USA 102 (2005) 14203–14208

    Article  ADS  Google Scholar 

  53. O.A. Sedelnikova, A. Nakamura, O. Kovalchuk, I. Koturbash, S.A. Mitchell, S.A. Marino, D.J. Brenner, W.M. Bonner, Cancer Res 67 (2007) 4295–4302

    Article  Google Scholar 

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Acknowledgment

The authors are grateful to Cancer Research UK [CUK] grant number C1513/A7047 and the European Union NOTE project (FI6R 036465) for funding their work.

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Authors and Affiliations

  1. Centre for Cancer Research & Cell Biology, Queen’s University Belfast, Belfast, BT9 7BL, UK

    Kevin M. Prise & Giuseppe Schettino

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  1. Kevin M. Prise
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  2. Giuseppe Schettino
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Correspondence to Kevin M. Prise .

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Editors and Affiliations

  1. , Consejo Superior de Investigaciones Cien, Instituto de Física Fundamental (IFF), Serrano 113-bis, Madrid, 28006, Spain

    Gustavo García Gómez-Tejedor

  2. Consejo Superior de Investigaciones Cien, Instituto de Física Fundamental (IFF), Serrano 113bis, Madrid, 28006, Spain

    Martina Christina Fuss

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Prise, K.M., Schettino, G. (2012). Spatial and Temporal Aspects of Radiation Response in Cell and Tissue Models. In: García Gómez-Tejedor, G., Fuss, M. (eds) Radiation Damage in Biomolecular Systems. Biological and Medical Physics, Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2564-5_23

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  • DOI: https://doi.org/10.1007/978-94-007-2564-5_23

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  • Online ISBN: 978-94-007-2564-5

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