Track-Structure Monte Carlo Modelling in X-ray and Megavoltage Photon Radiotherapy

  • Richard P. Hugtenburg
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)


The use of track structure calculations in radiotherapy using conventional low-LET radiation sources is discussed. Microdosimetry and emergent nanodosimetry methods are considered in explaining variations in quality factors associated with clinical practice and in vitro data. Transformation rate in the human derived for the in vitro system CGL1 is presented as a model for the induction of secondary cancer, a late effect associated with radiotherapy treatment.


Linear Energy Transfer Lineal Energy Cancer Induction Dicentric Formation Relative Biological Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Frank Verhaegen is acknowledged for providing his thesis and the basic data on lineal energy spectra therein. Geoff Heyes, Alan Beddoe and Ihsan Al Affan are thanked for their helpful discussion.


  1. 1.
    B.J. Mijnheer, J.J. Battermann, A. Wambersie, Radiotherapy and Oncology, 8, 237–252 (1987)CrossRefGoogle Scholar
  2. 2.
    C. Lindborg, J.-E. Grindborg, Radiat. Prot. Dosim. 70, 541–6 (1997)Google Scholar
  3. 3.
    W. Friedland, P. Jacob, H.G. Paretzke, M. Merzagora, A. Ottolenghi, Radiat. Environ. Biophys. 38 39–47 (1999)CrossRefGoogle Scholar
  4. 4.
    H. Nikjoo, P. ONeill, W.E. Wilson, D.T. Goodhead, Radiat. Res. 156 577–83 (2001)Google Scholar
  5. 5.
    Y. Hsiao, R.D. Stewart, Phys. Med. Biol. 53, 233–244 (2008)CrossRefGoogle Scholar
  6. 6.
    A.M. Kellerer, H.H. Rossi, Radiat. Res. 75, 471–488 (1978)CrossRefGoogle Scholar
  7. 7.
    M. Zaider, Med. Phys. 25, 791–792 (1998)CrossRefGoogle Scholar
  8. 8.
    R.K. Sachs, D.J. Brenner, Med. Phys. 25, 2071–2073 (1998)CrossRefGoogle Scholar
  9. 9.
    M. Zaider, Med. Phys. 25, 2074–5 (1998)CrossRefGoogle Scholar
  10. 10.
    D.J. Brenner, M. Zaider, Med. Phys. 25, 1055–1057 (1998)CrossRefGoogle Scholar
  11. 11.
    P. Pihet, H.G. Menzel, Med. Phys. 26, 848–852 (1999)CrossRefGoogle Scholar
  12. 12.
    D.J. Brenner, C.-S. Leu, J.F. Beatty, R.E. Shefer, Phys. Med. Biol. 44, 323–333 (1999)CrossRefGoogle Scholar
  13. 13.
    M. Zaider, L. Hanin, Med. Phys. 38, 574–583 (2011)CrossRefGoogle Scholar
  14. 14.
    F. Verhaegen, I.A. Castellano, Radiat. Prot. Dosim. 99, 393–6 (2002)Google Scholar
  15. 15.
    B. Reniers, F. Verhaegen, Radiat. Prot. Dosim. 122, 401–3 (2007)CrossRefGoogle Scholar
  16. 16.
    H.H. Liu, F. Verhaegen, Radiat. Prot. Dosim. 99, 425–7 (2002)Google Scholar
  17. 17.
    D.J. Carlson, R.D. Stewart, X.A. Li, K. Jennings, J.Z. Wang, M. Guerrero, Phys. Med. Biol. 49, 4477–4491 (2004)CrossRefGoogle Scholar
  18. 18.
    R.D. Stewart, X.A. Li, Med. Phys. 34, 3739–3751 (2007)CrossRefGoogle Scholar
  19. 19.
    D.J. Brenner, Semin. Radiat. Oncol. 18, 234-239 (2008)CrossRefGoogle Scholar
  20. 20.
    J.P. Kirkpatrick, J.J. Meyer, L.B. Marks, Semin. Radiat. Oncol. 18, 240-243 (2008)CrossRefGoogle Scholar
  21. 21.
    H.T.Jr. Peterson, J. Radiol. Prot. 30, 801–811 (2010)CrossRefGoogle Scholar
  22. 22.
    G.J. Heyes, A.J. Mill, M.W. Charles, J. Radiol. Prot. 29, A123–A132 (2009)Google Scholar
  23. 23.
    N. Hunter, C.R. Muirhead, J. Radiol. Prot. 29, 5–21 (2009)Google Scholar
  24. 24.
    J.E. Pattison, L.C. Payne, R.P. Hugtenburg, A.H. Beddoe, M.W. Charles, Radiat. Prot. Dosim. 109, 175–180 (2004)CrossRefGoogle Scholar
  25. 25.
    J.E. Pattison, R.P. Hugtenburg, A.H. Beddoe, M.W. Charles, Radiat. Prot. Dosim. 95, 125–135 (2001)Google Scholar
  26. 26.
    L. Walsh, W. Rühm, A.M. Kellerer, Radiat. Environ. Biophys. 43, 145–151 (2004)CrossRefGoogle Scholar
  27. 27.
    D. Harder, N. Petoussi-Henß, D. Regulla, M. Zankl, G. Dietze, Radiat. Prot. Dosim. 109, 291–295 (2004)CrossRefGoogle Scholar
  28. 28.
    A.M. Kellerer, H. Roos, Radiat. Prot. Dosim. 113, 245–250 (2005)CrossRefGoogle Scholar
  29. 29.
    R.D. Stewart, W.E. Wilson, J.C. McDonald, D.J. Strom, Phys. Med. Biol. 47, 79–88 (2002)CrossRefGoogle Scholar
  30. 30.
    C.S. Liu, C.-J. Tung, Y.H. Hu, C.M. Chou, T.C. Chao, C.C. Lee, Nucl. Instrum. Meths. B. 267, 1823–9 (2009)CrossRefADSGoogle Scholar
  31. 31.
    T.C. Chao, Y.S. Huang, F.Y. Hsu, Y. Hsiao, C.C. Lee, C.J. Tung, Radiat. Prot. Dosim. 143, 248–252 (2011)CrossRefGoogle Scholar
  32. 32.
    R.P. Hugtenburg, Z. Chaoui, J.E. Pattison, Nucl Instrum. Meths. A 580, 157–160 (2007)CrossRefADSGoogle Scholar
  33. 33.
    R.P. Hugtenburg, Eu. J. Radiol. 68, S126–8 (2008)CrossRefGoogle Scholar
  34. 34.
    R.P. Hugtenburg, A.E.R. Baker, S. Green, Appl. Radiat. Isotop. 67, 433–5 (2009)CrossRefGoogle Scholar
  35. 35.
    R.P. Hugtenburg, A.E.R. Baker, S. Green, Appl. Radiat. Isotop. 67, S168-170 (2009)CrossRefGoogle Scholar
  36. 36.
    M. Zaider, D.J. Brenner, Radiat. Res. 103, 302–316 (1985)CrossRefGoogle Scholar
  37. 37.
    ICRU: Report 40. The quality factor in radiation protection. International Commission of Radiation Units and Measurements, Bethesda, MA, (1986)Google Scholar
  38. 38.
    R.J. Cannell, D.E. Watt, Phys. Med. Biol. 30, 255-258 (1985)CrossRefGoogle Scholar
  39. 39.
    A.V. Lappa, E.A. Bigildeev, D.S. Burmistrov, O.N. Vasilyev, Radiat. Environ. Biophys. 32, 1–19 (1993)CrossRefGoogle Scholar
  40. 40.
    E.A. Bigildeev, V. Michalik, Radiat. Phys. Chem. 47, 197–207 (1996)CrossRefADSGoogle Scholar
  41. 41.
    W. Friedland, M. Dingfelder, P. Jacob, H.G. Paretzke, Radiat. Phys. Chem. 72, 279–86 (2005)CrossRefADSGoogle Scholar
  42. 42.
    H.H. Rossi, M. Zaider, Microdosimetry and its applications, Springer-Verlag, Berlin (1996)CrossRefGoogle Scholar
  43. 43.
    A. Mozumder, Y. Hatano, (Eds.), Charged Particle and Photon Interactions with Matter. Chemical, Physicochemical and Biological Consequences with Applications, Marcel Dekker, New York, (2004)Google Scholar
  44. 44.
    G. Garty, S. Shchemelinin, A. Breskin, R. Chechik, G. Assaf, I. Orion, V. Bashkirov, R. Schulte, B. Grosswendt, B.: Nucl. Instrum. Meth. A, 492 212–235 (2002)Google Scholar
  45. 45.
    M.N. Cornforth, K.M. Greulich-Bode, B.D. Loucas, J. Arsuaga, M. Vázquez, Sachs, M. Brückner, M. Molls, P. Hahnfeldt, L. Hlatky, D.J. Brenner, J. Cell Biol. 159 237-244Google Scholar
  46. 46.
    H.H. Rossi, Radiation Protection Dosimetry 52, 9–12 (1994)Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.College of MedicineSwansea UniversitySwanseaUK

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