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Intracellular Delivery: A Multifunctional and Modular Approach

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Intracellular Delivery

Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 5))

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Abstract

Intracellular delivery of drugs and nucleic acids has become one of the most widely explored areas of research. However, it has become increasingly evident that it is also necessary to control the nanocarrier’s disposition within a cell. Much attention has been paid nowadays to control the distribution of the nanocarrier within the cell by using organelle targeted nanocarriers. In this review we have described various approaches developed in our laboratory for intracellular delivery of drugs and nucleic acids with lipid-based nanocarriers.

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Abbreviations

EPR:

enhanced permeability and retention

PEG:

polyethylene glycol

PEG-PE:

polyethylene glycol-phosphatidyl ethanolamine

CPPs:

cell penetrating peptides

LL:

Lipofectin® lipids

PTDs:

protein Transduction Domains

HIV-1:

human immunodeficiency virus type 1

pNP-PEG-PE:

(p-nitrophenyl) carbonyl-PEG-PE

QDs:

quantum dots

APC:

antigen presenting cells

PC:

egg phosphatidylcholine

Chol:

cholesterol

Rh:

rhodamine

DDS:

drug delivery system

STPP:

stearyl triphenyl phosphonium

Rh-123:

rhodamine-123

PCL:

paclitaxel

LSD:

lysosomal storage diseases

ERT:

enzyme replacement therapy

RhB:

octadecyl derivative of rhodamine B

C12FDG:

5-dodecanoylamino fluorescein di-β-D-galactopyranoside

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA, 02115, USA

    Rupa R. Sawant & Vladimir P. Torchilin

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  1. Rupa R. Sawant
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  2. Vladimir P. Torchilin
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Correspondence to Vladimir P. Torchilin .

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  1. , Chemical and Biological Engineering, Vanderbilt University, VU Station B 351604, Nashville, 37235, Tennessee, USA

    Aleš Prokop

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Sawant, R.R., Torchilin, V.P. (2011). Intracellular Delivery: A Multifunctional and Modular Approach. In: Prokop, A. (eds) Intracellular Delivery. Fundamental Biomedical Technologies, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1248-5_8

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