Advertisement

Parasites and Oncogenesis with a Special Reference to Gastro-Intestinal Neoplasia Induced by Cryptosporidium parvum

  • C CreusyEmail author
  • G Certad
  • K Guyot
  • E Dei-Cas
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)

Abstract

In the last years a large number of infectious agents including virus, bacteria and parasites have been identified as direct causes or as risk factors to specific cancers around the world. Among the parasites linked to oncogenesis in humans there are strong associations. Particularly, Schistosoma haematobium is usually recognized as a cause of urinary bladder carcinoma. Some hepatic and colorectal cancers have been linked to infection by S. japonicum or S. mansoni. Moreover, a high proportion of cholangiocarcinoma in Far-East countries was imputable to Opisthorchiidae liver flukes. Among the parasitic Protists, the Apicomplexan Theileria annulata and T. parva, which are the agents of theileriosis in cows, induce often lethal lymphoproliferative process in these animals. The association between Cryptosporidium and digestive carcinomas has also been reported in a clinic study in Poland. More recently, the ability of C. parvum to induce neoplastic changes was established experimentally. This model revealed that C. parvum strains are able to induce gastrointestinal intraepithelial neoplasia in dexamethasone-treated SCID mice. Neoplastic lesions spread often to more than one digestive organ, and severity correlated with the inoculum size and the duration of the infection. Further studies are needed in order to characterize this process in mice, and to explore its occurrence in human cryptosporidiosis.

Keywords

Parasites cancer oncogenesis gastro-intestinal neoplasia Cryptosporidium parvum 

References

  1. Bhagwandeen SB (1976) Schistosomiasis and carcinoma of the bladder in Zambia. S Afr Med J 50:1616–1620PubMedGoogle Scholar
  2. Caccio SM, Pozio E (2006) Advances in the epidemiology, diagnosis and treatment of cryptosporidiosis. Expert Rev Anti Infect Ther 4:429–443PubMedCrossRefGoogle Scholar
  3. Certad G, Ngouanesavanh T, Guyot K, Gantois N, Chassat T, Mouray A, Fleurisse L, Pinon A, Cailliez JC, Dei-Cas E, Creusy C (2007) Cryptosporidium parvum, a potential cause of colic adenocarcinoma. Infect Agent Cancer 2:22PubMedCrossRefGoogle Scholar
  4. Certad G, Creusy C, Ngouanesavanh T, Guyot K, Gantois N, Mouray A, Chassat T, Flament N, Fleurisse L, Pinon A, Delhaes L, Dei-Cas E (2010) Development of Cryptosporidium parvum induced gastro-intestinal neoplasia in SCID mice: Severity of lesions is correlated with infection intensity. Am J Trop Med Hyg 82:257–265PubMedCrossRefGoogle Scholar
  5. Chen XM, Levine SA, Splinter PL, Tietz PS, Ganong AL, Jobin C, Gores GJ, Paya CV, LaRusso NF (2001) Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis. Gastroenterology 120:1774–1783PubMedCrossRefGoogle Scholar
  6. Darwish MA, Raouf TA, Rushdy P, Constantine NT, Rao MR, Edelman R (1993) Risk factors associated with a high seroprevalence of hepatitis C virus infection in Egyptian blood donors. Am J Trop Med Hyg 49:440–447PubMedGoogle Scholar
  7. de Martel C, Franceschi S (2009) Infections and cancer: Established associations and new hypotheses. Crit Rev Oncol Hematol 70:183–194PubMedCrossRefGoogle Scholar
  8. Dobbelaere DA, Fernandez PC, Heussler VT (2000) Theileria parva: taking control of host cell proliferation and survival mechanisms. Cell Microbiol 2:91–99PubMedCrossRefGoogle Scholar
  9. Dobbelaere DA, Rottenberg S (2003) Theileria-induced leukocyte transformation. Curr Opin Microbiol 6:377–382PubMedCrossRefGoogle Scholar
  10. Halim AB, Garry RF, Dash S, Gerber MA (1999) Effect of schistosomiasis and hepatitis on liver disease. Am J Trop Med Hyg 60:915–920PubMedGoogle Scholar
  11. Heine J, Moon HW, Woodmansee DB (1984) Persistent Cryptosporidium infection in congenitally athymic (nude) mice. Infect Immun 43:856–859PubMedGoogle Scholar
  12. Heussler VT, Kuenzi P, Rottenberg S (2001) Inhibition of apoptosis by intracellular protozoan parasites. Int J Parasitol 31:1166–1176PubMedCrossRefGoogle Scholar
  13. Hicks RM, Ismail MM, Walters CL, Beecham PT, Rabie MF, El Alamy MA (1982) Association of bacteriuria and urinary nitrosamine formation with Schistosoma haematobium infection in the Qalyub area of Egypt. Trans R Soc Trop Med Hyg 76:519–527PubMedCrossRefGoogle Scholar
  14. Izquierdo J, Antunez I, Calderon MT, Perez Giraldo C, Munoz Sanz A (1988) Diarrhea caused by Cryptosporidium and colonic neoplasia. Rev Clin Esp 182:393–394PubMedGoogle Scholar
  15. Khurana S, Dubey ML, Malla N (2005) Association of parasitic infections and cancers. Indian J Med Microbiol 23:74–79PubMedCrossRefGoogle Scholar
  16. Laha T, Pinlaor P, Mulvenna J, Sripa B, Sripa M, Smout MJ, Gasser RB, Brindley PJ, Loukas A (2007) Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini. BMC Genomics 8:189PubMedCrossRefGoogle Scholar
  17. Lizundia R, Chaussepied M, Huerre M, Werling D, Di Santo JP, Langsley G (2006) c-Jun NH2-terminal kinase/c-Jun signaling promotes survival and metastasis of B lymphocytes transformed by Theileria. Cancer Res 66:6105–6110PubMedCrossRefGoogle Scholar
  18. Lopez-Velez R, Tarazona R, Garcia Camacho A, Gomez-Mampaso E, Guerrero A, Moreira V, Villanueva R (1995) Intestinal and extraintestinal cryptosporidiosis in AIDS patients. Eur J Clin Microbiol Infect Dis 14:677–681PubMedCrossRefGoogle Scholar
  19. Lowe SW, Lin AW (2000) Apoptosis in cancer. Carcinogenesis 21:485–495PubMedCrossRefGoogle Scholar
  20. Mele R, Gomez Morales MA, Tosini F, Pozio E (2004) Cryptosporidium parvum at different developmental stages modulates host cell apoptosis in vitro. Infect Immun 72:6061–6067PubMedCrossRefGoogle Scholar
  21. Pagano J, Blaser M, Buendia M, Damania B, Khalili K, Raab-Traub N, Roizman B (2004) Infectious agents and cancer: criteria for a causal relation. Semin Cancer Biol 14:453–471PubMedCrossRefGoogle Scholar
  22. Parkin DM (2006) The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118:3030–3044PubMedCrossRefGoogle Scholar
  23. Patel P, Hanson DL, Sullivan PS, Novak RM, Moorman AC, Tong TC, Holmberg SD, Brooks JT (2008) Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003. Ann Intern Med 148:728–736PubMedGoogle Scholar
  24. Pozio E, Morales MA (2005) The impact of HIV-protease inhibitors on opportunistic parasites. Trends Parasitol 21:58–63PubMedCrossRefGoogle Scholar
  25. Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ (2007) Liver fluke induces cholangiocarcinoma. PLoS Med 4:e201PubMedCrossRefGoogle Scholar
  26. Sulzyc-Bielicka V, Kuzna-Grygiel W, Kolodziejczyk L, Bielicki D, Kladny J, Stepien-Korzonek M, Telatynska-Smieszek B (2007) Cryptosporidiosis in patients with colorectal cancer. J Parasitol 93:722–724PubMedCrossRefGoogle Scholar
  27. Sunnotel O, Lowery CJ, Moore JE, Dooley JS, Xiao L, Millar BC, Rooney PJ, Snelling WJ (2006) Cryptosporidium. Lett Appl Microbiol 43:7–16PubMedCrossRefGoogle Scholar
  28. Uhl EW, Jacobson E, Bartick TE, Micinilio J, Schimdt R (2001) Aural-pharyngeal polyps associated with Cryptosporidium infection in three iguanas (Iguana iguana). Vet Pathol 38:239–242PubMedCrossRefGoogle Scholar
  29. Xiao L, Fayer R, Ryan U, Upton SJ (2004) Cryptosporidium taxonomy: recent advances and implications for public health. Clin Microbiol Rev 17:72–97PubMedCrossRefGoogle Scholar
  30. Ziegler J, Buonaguro F (2009) Infectious agents and human malignancies. Front Biosci 1:3455–3464CrossRefGoogle Scholar
  31. zur Hausen H (2009) The search for infectious causes of human cancers: where and why. Virology 392:1–10PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Pathology & Cytology ServiceGroupe Hospitalier de l’Université Catholique de LilleLilleFrance
  2. 2.Laboratoire d’anatomie et de cytologie pathologiquesCentre Hospitalier Saint Vincent de PaulLILLE CedexFrance
  3. 3.Ecology of Parasitism (ECOPA) ServiceIFR-142 Institut Pasteur de LilleLilleFrance
  4. 4.Parasitology-Mycology Service, Microbiology Department, EA3609, Faculty of Medicine, UDSLUniv Lille Nord de France, Univ Hospital Centre & IFR-142 Institut Pasteur de LilleLilleFrance
  5. 5.Parasitology Department, “José-María Vargas” School of MedicineCentral University of VenezuelaCaracasVenezuela

Personalised recommendations