Skip to main content
SpringerLink
Log in

Intestinal and extraintestinal cryptosporidiosis in AIDS patients

  • Articles
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

In a prospective study in AIDS patients with chronic diarrhea, the overall prevalence of intestinal cryptosporidiosis was 15.6% (43/275). The prevalence was higher in homosexual patients (33.3 %) than in intravenous drug abusers (10.6 %) (p<0.001). Extraintestinal infection was present in 30 % (13/43) of the patients with known intestinal cryptosporidiosis. Eight of the 13 (61.5 %) patients with extraintestinal cryptosporidiosis hadCryptosporidium in the bile and 7 of 13 (16.28 %) had it in the sputum. Of the seven patients withCryptosporidium in the sputum, four had respiratory symptoms and an abnormal chest radiograph, although another pulmonary pathogen was isolated simultaneously. Two other patients from whomCryptosporidium was the sole respiratory pathogen isolated had no respiratory symptoms and normal chest radiographs. The seventh patient had pulmonary symptoms, interstitial infiltrate on chest radiograph and excessive activity on a pulmonary Gallium scan;Cryptosporidium was the only organism detected in induced sputum and bronchoalveolar lavage specimens. The mean CD4+ lymphocyte count in patients with extraintestinal cryptosporidiosis was 55 cells/mm3.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Petersen C: Cryptosporidiosis in patients infected with the human immunodeficiency virus. Clinical Infectious Diseases 1992, 15: 903–909.

    PubMed  Google Scholar 

  2. Cotte L, Rabodoniria M, Piens MA, Perreard M, Mojon M, Trepo C: Prevalence of intestinal protozoans in French patients infected with HIV. Journal of Acquired Immune Deficiency Syndromes 1993, 6: 1024–1029.

    PubMed  Google Scholar 

  3. Sauda FC, Zamarioli LA, Ebner-Filho W, Mello LB: Prevalence ofCryptosporidium spp. andIsospora belli among AIDS patients attending Santos Reference Center for AIDS, Sao Paulo, Brazil. Journal of Parasitology 1993, 79: 454–456.

    PubMed  Google Scholar 

  4. Roulot D, Valla D, Brun-Vezinet F: Cholangitis in the acquired immunodeficiency syndrome: report of two cases and review of the literature. Gut 1987, 28:1653–1660.

    PubMed  Google Scholar 

  5. Hawkins SP, Thomas RP, Teasdale C: Acute pancreatitis: a new finding inCryptosporidium enteritis. British Medical Journal 1987, 294: 483–484.

    Google Scholar 

  6. Brady EM, Margolis ML, Korzeniowski OM: Pulmonary cryptosporidiosis in acquired immune deficiency syndrome. Journal of the American Medical Association 1984, 252: 89–90.

    PubMed  Google Scholar 

  7. Tee GH, Moody AH, Cooke AH, Chiodini PL: Comparison of techniques for detecting antigens ofGiardia lamblia andCryptosporidium parvum in feces. Journal of Clinical Pathology 1993, 46: 555–558.

    PubMed  Google Scholar 

  8. Soave R, Danner RL, Honig CL: Cryptosporidiosis in homosexual men. Annals of Internal Medicine 1984, 100: 504–511.

    PubMed  Google Scholar 

  9. Navin TR, Juranek DD: Cryptosporidiosis: clinical, epidemiologic and parasitologic review. Reviews of Infectious Diseases 1984, 6: 313–327.

    PubMed  Google Scholar 

  10. Flanigan T, Whallen C, Turner J:Cryptosporidium infection and CD4+ counts. Annals of Internal Medicine 1992, 116: 840–842.

    PubMed  Google Scholar 

  11. Soave R, Johnson WD Jr:Cryptosporidium andIsospora belli infections. Journal of Infectious Diseases 1988, 157: 225–229.

    PubMed  Google Scholar 

  12. McCarty M, Choudhri AH, Heibert M, Crofton ME: Radiological features of AIDS related cholangitis. Clinical Radiology 1989, 40: 582–585.

    PubMed  Google Scholar 

  13. Bouche H, Housset C, Dumont JL: AIDS related cholangitis: diagnostic features and course in 15 patients. Journal of Hepatology 1993, 17: 34–39.

    PubMed  Google Scholar 

  14. Roberts WG, Green PH, Ma J, Carr M, Ginsberg AM: Prevalence of cryptosporidiosis in patients undergoing endoscopy: evidence for an asymptomatic carrier state. American Journal of Medicine 1989, 87: 537–539.

    PubMed  Google Scholar 

  15. Harari MD:Cryptosporidium as cause of laryngotracheitis in an infant. Lancet 1986, ii: 1207.

    Google Scholar 

  16. Moore JA, Frekel JK: Respiratory and enteric cryptosporidiosis in humans. Archives of Pathology and Laboratory Medicine 1991, 115: 1160–1162.

    PubMed  Google Scholar 

  17. Forgacs P, Tarshis A, Ma P: Intestinal and bronchial cryptosporidiosis in an immunodeficient homosexual man. Annals of Internal Medicine 1983, 99: 793–794.

    PubMed  Google Scholar 

  18. Kocoshis SA, Cibul ML, Davis TE, Hinton JT, Seip M, Banwell JG: Intestinal and pulmonary cryptosporidiosis in an infant with severe combined immunodeficiency. Journal of Pediatric Gastroenterolgy and Nutrition 1984, 3: 149–157.

    Google Scholar 

  19. Gross TL, Wheat J, Bartlett M, O'Connor KW: AIDS and multiple system involvement withCryptosporidium. American Journal of Gastroenterology 1986, 81: 456–458.

    PubMed  Google Scholar 

  20. Anonymous: Clinicopathological conference. Immunodeficiency and cryptosporidiosis. British Medical Journal 1980, 281: 1123–1127.

    Google Scholar 

  21. Miller RA, Wasserheit JN, Kirihara J, Coyle MB: Detection ofCryptosporidium oocysts in sputum during screening for mycobacteria. Journal of Clinical Microbiology 1984, 20: 1192–1193.

    PubMed  Google Scholar 

  22. Ma P, Villanueva TJ, Kaufman D, Gillooley JF: Respiratory cryptosporidiosis in the acquired immune deficiency syndrome. Journal of the American Medical Association 1984, 252: 1298–1301.

    PubMed  Google Scholar 

  23. Kibbler CC, Smith A, Hamilton-Dutoit SJ, Milburn H, Pattinson JK, Prentice HG: Pulmonary cryptosporidiosis occurring in a bone marrow transplant patient. Scandinavian Journal of Infectious Diseases 1987, 19: 581–584.

    PubMed  Google Scholar 

  24. Manivel C, Filipovich A, Snover DC: Cryptosporidiosis as a cause of diarrhea following bone marrow transplantation. Diseases of the Colon and Rectum 1985, 28: 741–742.

    PubMed  Google Scholar 

  25. Davis JJ, Heyman MB: Cryptosporidiosis and sinusitis in an immunodeficient adolescent. Journal of Infectious Diseases 1988, 158: 649.

    PubMed  Google Scholar 

  26. Hojlyng N, Jensen BN: Respiratory cryptosporidiosis in HIV-positive patients. Lancet 1988, i: 590–591.

    Google Scholar 

  27. Goodstein RS, Colombo CS, Illfelder MA, Skaggs RE: Bronchial and gastrointestinal cryptosporidiosis in AIDS. Journal of the American Osteopathic Association 1989, 89: 195–197.

    PubMed  Google Scholar 

  28. Giang TT, Pollack G, Kotler DP: Cryptosporidiosis of the nasal mucosa in a patient with AIDS. AIDS 1994, 8: 555–556.

    PubMed  Google Scholar 

  29. Travis WD, Schmidt K, MacLowry JD, Masur H, Condron KS, Fojo AT: Respiratory cryptosporidiosis in a patient with malignant lymphoma. Archives of Pathology and Laboratory Medicine 1990, 114: 519–522.

    PubMed  Google Scholar 

  30. Gentile G, Venditti M, Micozzi A: Cryptosporidiosis in patients with hematologic malignancies. Reviews of Infectious Diseases 1991, 13: 842–846.

    PubMed  Google Scholar 

  31. Fripp PJ, Bothma MT, Crewe-Brown HH: Four years of cryptosporidiosis at GaRankuwa Hospital. Journal of Infection 1991, 23: 93–100.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Microbiology & Infectious Diseases, Hospital Ramon y Cajal, Apartado 31057, 28034, Madrid, Spain

    R. López-Vélez, A. Garcia Camacho, E. Gomez-Mampaso & A. Guerrero

  2. Department of Gastroenterology, Hospital Ramon y Cajal, Apartado 31057, 28034, Madrid, Spain

    V. Moreira

  3. Preventive Medicine & Public Health, Facultad de Medicina, Universidad Complutense, Madrid, Spain

    R. Tarazona & R. Villanueva

Authors
  1. R. López-Vélez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Tarazona
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Garcia Camacho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Gomez-Mampaso
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Guerrero
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. Moreira
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. Villanueva
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

López-Vélez, R., Tarazona, R., Camacho, A.G. et al. Intestinal and extraintestinal cryptosporidiosis in AIDS patients. Eur. J. Clin. Microbiol. Infect. Dis. 14, 677–681 (1995). https://doi.org/10.1007/BF01690873

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01690873

Keywords

Search

Navigation