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Biomedical Applications of Heat Shock Proteins

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Biomedical Applications of Natural Proteins

Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology ((BRIEFSBIOCHEM))

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Abstract

Heat shock proteins (HSPs) constitute a heterogeneous group of molecules which are phylogenetically conserved and initially known for their role in proper folding of nascent or misfolded proteins. Their expression is increased due to different stresses. Initially discovered due to heat stress, HSPs came beyond their role as molecular chaperones. Now there is evidence that HSPs perform functions more than what they were believed to earlier. There are reports that show that HSPs are actively involved in cell signaling and act as anti-inflammatory and pro-inflammatory agents in normal and in different ailments. Normally, HSPs are found inside the cell but they are also found secreted into the extracellular milieu and displayed onto the cell surface to represent different cellular conditions. While present on the cell surface they also carry processed peptides of the respective cell. Their solubility nature evokes most of the immune modulatory effects on different cell types. This versatile nature of HSPs can be employed for different biomedical applications. HSPs, both as diagnostic markers as well as drug targets in the field of autoimmune diseases, different cancers, are discussed here. Few non-biomedical but commercially important applications are also discussed in brief.

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Authors and Affiliations

  1. Department of Molecular Biology, National Aids Research Institute, 411029, Pune, India

    Rajesh R. Kundapur

  2. Department of Zoology, School of Life Sciences, Guru Ghasidas Vishwavidyalaya, 495009, Bilaspur, India

    Dhiraj Kumar

  3. Molecular Biology Laboratory, School of Biology and Basic Medical Science, Soochow University, 215123, Suzhou, China

    Dhiraj Kumar

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  1. Rajesh R. Kundapur
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Correspondence to Rajesh R. Kundapur .

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Editors and Affiliations

  1. Department of Zoology, School of Life Science, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

    Dhiraj Kumar

  2. Department of Molecular Biology, National AIDS Research Institute, Pune, Maharashtra, India

    Rajesh R. Kundapur

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Kundapur, R.R., Kumar, D. (2015). Biomedical Applications of Heat Shock Proteins. In: Kumar, D., R. Kundapur, R. (eds) Biomedical Applications of Natural Proteins. SpringerBriefs in Biochemistry and Molecular Biology. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2491-4_2

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