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Growth Controlled Fed-Batch Cultivations — Theory, Development of Control Strategies and Experimental Verification —

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Biochemical Engineering for 2001

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Abstract

The cultivation of genetically modified microorganisms, e.g.E. coli, larger than 100 g/L dry weight, requires fed-batch processing with aid of a controlled specific growth rate fi. A theoretical analysis of this kind of fed-batch processes, as well as a method to control /z will be discussed and the implementation of both in an industrial process control system will be shortly explained. The test of the control equipment is carried out with the help of on-line simulation methods. The experimental verification of the developed control methods is demonstrated with a high cell densityE. colicultivation.

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References

  1. Luttmann R (1991) Automatic Control of Bioreactors. In: Introduction to Industrial Biotechnology, Coursebook of the 5th International Training Programme in Biotechnology, GBF Braunschweig, Germany

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  2. Luttmann R, Stilkenbäumer A, Ross A (1990) Regelung intrazellulärer Aktivitätsgrößen in Bioreaktoren. BioEngineering 6: 12–22

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  3. Luttmann R et al. (1991) Control of Cell Specific Activities with Industrial Process Control Systems. In: Recent Advances in Industrial Applications of Biotechnology, NATO ASI-Preprints, Kusadase, Türkiye: 334–339

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  4. Luttmann R et al. (1992) Applications of Industrial Process Control Systems in Biotechnology. Process Control and Quality (submitted)

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  5. Riesenberg D et al. (1991) High Cell Density Cultivation of Escherichia coli at Controlled Specific Growth Rate. J. Biotechn. 20: 17–28

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of Bioprocess Control, Polytechnic Hamburg, Lohbrügger Kirchstr. 65, W-2050, Hamburg, Germany

    Reiner Luttmann & Jens Hartkopf

  2. Department of Biochemical Engineering, GBF — National Research Center for Biotechnology Ltd, Mascheroder Weg 1, W-3300, Braunschweig, Germany

    Anton Ross

Authors
  1. Reiner Luttmann
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  2. Jens Hartkopf
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  3. Anton Ross
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Editor information

Editors and Affiliations

  1. Department of Chemical Engineering, Faculty of Engineering, The University of Tokyo, 3-1 Hongo 7-chome, Bunkyo-ku, Tokyo 113, Japan

    Shintaro Furusaki

  2. The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako-shi, Saitama, 351-01, Japan

    Isao Endo (Head of Chemical Engineering Laboratory) (Head of Chemical Engineering Laboratory)

  3. Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto, 606-01, Japan

    Ryuichi Matsuno

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© 1992 Springer-Verlag Tokyo

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Luttmann, R., Hartkopf, J., Ross, A. (1992). Growth Controlled Fed-Batch Cultivations — Theory, Development of Control Strategies and Experimental Verification —. In: Furusaki, S., Endo, I., Matsuno, R. (eds) Biochemical Engineering for 2001. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68180-9_178

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  • DOI: https://doi.org/10.1007/978-4-431-68180-9_178

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68182-3

  • Online ISBN: 978-4-431-68180-9

  • eBook Packages: Springer Book Archive

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