Abstract
It has been reported that LEC rats are a useful animal model for spontaneous fulminant hepatitis [1] and liver cell carcinoma [2]. At 16–20 weeks of age, 80%–90% of LEC rats spontaneously develop severe hepatic disease, but its etiopathogenesis has not yet been clarified. The clinical features of these LEC rats are marked jaundice, ascitis, subcutaneous bleeding, and oliguria, and their low urinary output suggests the presence of an accompanying renal lesion. In this paper, we present the laboratory data and histopathological findings in the liver and kidney of LEC rats — hepatocellular lipid degeneration and acute renal failure due to acute tubular necrosis — and suggest that LEC rats can serve as an animal model for human hepatorenal syndrome.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Takeichi N, Kobayashi H, Yoshida MC, Sasaki M, Dempo K, Mori M (1988) Spontaneous hepatitis in Long-Evans rats. Acta Pathol Jpn 38:1369–1375.
Masuda R, Yoshida MC, Sasaki M, Dempo K, Mori M (1988) A transplantable cell line derived from spontaneous hepatocellular carcinoma of the hereditary hepatitis LEC rat. Jpn J Cancer Res 79:250–254.
Epstein M (1988) Hepatorenal syndrome. In: Epstein M (ed) The kidney in liver diseases. Williams and Wilkins, Baltimore p 89.
Weinberg AG, Mize CE, Worthen HG (1976) The occurrence of hepatoma in the chronic form of hereditary tyrosinemia. J Pediatr 88:434–438.
Hovig T, Blomhoff JP, Holme R, Flatmark A, Gjone E (1978) Plasma lipoprotein alerations and morphologic changes with lipid deposition in the kidney of patients with hepatorenal syndrome. Lab Invest 38:540–549.
Elsas LJ, Hayslett JP, Spargo BH, Durant JL, Rosengerg LE (1971) Wilson’s disease with reversible renal tubular dysfunction: Correlation with proximal tubular ultra structure. Ann Intern Med 75:427–435.
Masuda R, Yoshida MC, Sasaki M, Dempo K, Mori M (1988) Hereditary hepatitis of LEC rats is controlled by autosomal recessive gene. Lab Anim 22:166–172.
Koppel MH, Coburn JW, Mims MM, Goldstein H, Boyle JD, Rubini ME (1969) Transplantation of cadaveric kidneys from patients with advanced liver disease. N Engl J Med 280:1367–1371.
Mandel AK, Lansig M, Fahmy A (1982) Acute tubular necrosis in hepatorenal syndrome: An electron microscopy study. Am J Kidney Dis 2:363–374.
Solez K (1983) Pathogenesis of acute renal failure. Int Rev Exp Pathol 24: 277–333.
Solez K, Racusen LC, Jewell LD (1988) Pathology of acute renal failure occurring in liver disease. In: Epstein M (ed) The Kidney in liver disease. Williams and Willkins, Baltimore, p 182.
Wilkinson SP, Hirst D, Day DW, Wiliams R (1976) Spectrum of renal damage in renal failure secondary to cirrhosis and fulminant hepatic failure. J Clin Pathol 31:101–107.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Tokyo
About this chapter
Cite this chapter
Tochimaru, H., Akutsu, Y., Nagata, Y., Takekoshi, Y., Matsumoto, S., Takeichi, N. (1991). Acute Tubular Necrosis in LEC Rats with Hereditary Hepatic Failure — A New Animal Model of Hepatorenal Syndrome. In: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (eds) The LEC Rat. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68153-3_11
Download citation
DOI: https://doi.org/10.1007/978-4-431-68153-3_11
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68155-7
Online ISBN: 978-4-431-68153-3
eBook Packages: Springer Book Archive