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The LEC Rat

A New Model for Hepatitis and Liver Cancer

  • Michio Mori
  • Michihiro C. Yoshida
  • Noritoshi Takeichi
  • Naoyuki Taniguchi

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Establishment and Natural History

    1. Front Matter
      Pages 1-1
    2. Michihiro C. Yoshida, Motomichi Sasaki, Ryuichi Masuda
      Pages 3-10
    3. Noriyuki Kasai, Eikichi Kamimura, Ichiro Miyoshi, Michihiro C. Yoshida
      Pages 11-19
    4. Kazuto Yamazaki, Masaaki Nakayama, Koji Tomobe, Hiroshi Ohyama, Yumi Sawada, Tsuneo Wakabayashi et al.
      Pages 20-29
    5. Kazuya Kawano, Tsukasa Hirashima, Shigehito Mori, Sumio Bando, Kenichi Yonemoto, Fumiko Abe et al.
      Pages 30-40
    6. Tsutomu Namieno, Noritoshi Takeichi, Motomichi Sasaki, Kimimaro Dempo, Michio Mori, Jun-ichi Uchino et al.
      Pages 41-53
    7. Ryuichi Masuda, Michihiro C. Yoshida, Motomichi Sasaki, Kimimaro Dempo, Michio Mori
      Pages 54-66
  3. Hepatitis

    1. Front Matter
      Pages 67-67
    2. Pathology

      1. Tsutomu Namieno, Noritoshi Takeichi, Motomichi Sasaki, Kimimaro Dempo, Michio Mori, Jun-ichi Uchino et al.
        Pages 70-80
      2. Hidetoshi Takahashi, Katsuhiko Enomoto, Hirofumi Sakamoto, Hirotoshi Tobioka, Kimimaro Dempo, Michio Mori
        Pages 87-94
      3. Hirofumi Sakamoto, Yasuhiro Kamimura, Takashi Minase, Shigeaki Yokoyama, Masaaki Satoh, Michio Mori
        Pages 95-102
      4. Hiroyuki Tochimaru, Yasushi Akutsu, Yasushi Nagata, Yasuo Takekoshi, Shuzo Matsumoto, Noritoshi Takeichi
        Pages 103-113
      5. Keisuke Izumi, Hisanori Uehara, Hisashi Otsuka, Kozo Matsumoto
        Pages 114-119
    3. Biochemistry

      1. Takao Ono, Syuiti Abe, Michihiro C. Yoshida
        Pages 133-141
      2. Keiichiro Suzuki, Toshiyuki Nakata, Han Geuk Seo, Nobuko Miyazawa, Toshihiro Sugiyama, Naoyuki Taniguchi
        Pages 142-148
      3. Toshihiro Sugiyama, Mikako Matsunaga, Yoshitaka Ikeda, Naoyuki Taniguchi
        Pages 155-161
      4. Suresh K. Jain, Kenji Suzuki, Sadhana Jain, Toshihiro Sugiyama, Naoyuki Taniguchi
        Pages 162-168
      5. Masako Taniguchi, Toshihiro Sugiyama, Naoyuki Taniguchi
        Pages 169-174
      6. Toshihiko Nagase, Toshihiro Sugiyama, Shigeki Higashiyama, Daitoku Sakamuro, Sumio Kawata, Seiichiro Tarui et al.
        Pages 175-184
      7. Peter J. Wirth, Yoshinori Fujimoto, Michio Mori, Minako Nagao, Takashi Sugimura
        Pages 185-194
    4. Immunology

      1. Tsutomu Namieno, Noritoshi Takeichi, Motomichi Sasaki, Kimimaro Dempo, Michio Mori, Jun-ichi Uchino et al.
        Pages 196-208
      2. Atsuo Hattori, Yasuhiro Konishi, Hiroshi Isomura, Kouki Inaoka, Yun Zhong, Michio Mori
        Pages 209-216
      3. Yoshitaka Ikeda, Toshihiro Sugiyama, Naoyuki Taniguchi
        Pages 217-221
      4. Takashi Agui, Kozo Matsumoto
        Pages 232-239
  4. Liver Cancer

    1. Front Matter
      Pages 241-241
    2. Cytogenetics and Oncogenes

      1. Ryuichi Masuda, Takao Ono, Michihiro C. Yoshida, Motomichi Sasaki
        Pages 244-260
      2. Ryuichi Masuda, Syuiti Abe, Michihiro C. Yoshida, Motomichi Sasaki, Toshihiro Sugiyama, Naoyuki Taniguchi
        Pages 261-272
      3. Minako Nagao, Yoshinori Fujimoto, Yukihito Ishizaka, Katsuhiko Enomoto, Hidetoshi Takahashi, Michio Mori et al.
        Pages 273-279
    3. Pathology

      1. Tsutomu Namieno, Noritoshi Takeichi, Motomichi Sasaki, Kimimaro Dempo, Michio Mori, Jun-ichi Uchino et al.
        Pages 282-297
      2. Kazuya Kawano, Tsukasa Hirashima, Shigehito Mori, Sumio Bando, Kenichi Yonemoto, Fumiko Abe et al.
        Pages 298-304
      3. Katsuhiko Enomoto, Masakuni Sawaki, Hidetoshi Takahashi, Yasuo Nakajima, Kimimaro Dempo, Michio Mori
        Pages 305-312
      4. Yasuo Nakajima, Katsuhiko Enomoto, Hidetoshi Takahashi, Mutsomi I. Satoh, Masahito Oyamada, Michio Mori
        Pages 313-319
      5. Norimasa Sawada, Hirohumi Sakamoto, Hidetoshi Takahashi, Katsuhiko Enomoto, Yumiko Oyamada, Michio Mori
        Pages 320-325
    4. Biochemistry

      1. Ryuichi Masuda, Toshihiro Sugiyama, Naoyuki Taniguchi, Michihiro C. Yoshida, Motomichi Sasaki
        Pages 328-334
      2. Sadhana Jain, Suresh K. Jain, Toshihiro Sugiyama, Naoyuki Taniguchi
        Pages 335-340
  5. Back Matter
    Pages 349-356

About this book

Introduction

The LEC strain of rats, which spontaneously develop acute hepatitis as­ sociated with jaundice, chronic hepatitis, and ultimately hepatocellular carcinomas, was established by scientists in Sapporo, Japan. Careful ob­ servation and breeding led to the initial discovery of this characteristic, inherited liver disease in rats. Subsequent collaboration between scientists in Sapporo and other centers has revealed an autosomal recessive nature of inheritance, along with a variety of histopathological and biochemical findings. The causative mechanism(s) underlying this abnormality remained a mystery for some time, providing a challenge for many scientists who were attracted to the quest for clues to this enigma. In particular, the mech­ anism of spontaneous development of hepatocellular carcinomas in rats overcoming the acute phase of hepatitis and surviving with chronic hepatitis proved extremely interesting, because the involvement of a causative virus had been excluded in the early stages of investigation. Professor Michio Mori of Sapporo Medical College played a key role in the study of LEC rats, especially in the elucidation of the pathogenesis of hepatitis and hepatocellular carcinoma. He is one of the editors of this monograph which is composed of original contributions by the many scientists who have carried out their own studies on LEC rats. Of the various histopathological and biochemical alterations which have been reported, some are clearly secondary or tertiary events sequential to the primary change caused by gene mutation.

Keywords

Hepatitis B aging cancer carcinogenesis carcinoma cytogenetics cytokines genetics hepatitis hepatocellular carcinoma liver liver disease oncogene pathology pregnancy

Editors and affiliations

  • Michio Mori
    • 1
  • Michihiro C. Yoshida
    • 2
  • Noritoshi Takeichi
    • 3
  • Naoyuki Taniguchi
    • 4
  1. 1.Department of PathologySapporo Medical CollegeMinami 1, Nishi 17, Chuo-ku, Sapporo, 060Japan
  2. 2.Chromosome Research Unit, Faculty of ScienceHokkaido UniversityKita 10, Nishi 8, Kita-ku Sapporo, 060Japan
  3. 3.Laboratory of Pathology, Cancer InstituteHokkaido University School of MedicineKita 15, Nishi 7, Kita-ku, Sapporo, 060Japan
  4. 4.Department of BiochemistryOsaka University Medical SchoolSuita, Osaka, 565Japan

Bibliographic information