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Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis

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Systemic Sclerosis

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Abstract

The IL-1 family consists of 11 cytokines. Initially, IL-1α, IL-1β, and IL-1 receptor antagonists were discovered; then, IL-1’s specific receptors were identified. Subsequent studies are aimed to find molecules that bind to IL-1 receptor-like proteins (IL-1 receptor-related protein, ST2). As a result, in 2005, IL-33 was identified as a ligand of ST2. IL-33 is very similar to IL-1α in its biological properties. Our group has investigated the roles of IL-1α in the pathogenesis of tissue fibrosis in systemic sclerosis, and we are currently interested in the roles of IL-33 as well as IL-1α. Herein, I review the involvement of both of these molecules in systemic sclerosis.

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Authors and Affiliations

  1. Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan

    Yasushi Kawaguchi

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  1. Yasushi Kawaguchi
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Correspondence to Yasushi Kawaguchi .

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Editors and Affiliations

  1. Department of Dermatology, Kanazawa University, Kanazawa, Ishikawa, Japan

    Kazuhiko Takehara

  2. Department of Dermatology, University of Tsukuba, Tsukuba, Ibaraki, Japan

    Manabu Fujimoto

  3. Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Tokyo, Japan

    Masataka Kuwana

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Kawaguchi, Y. (2016). Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis. In: Takehara, K., Fujimoto, M., Kuwana, M. (eds) Systemic Sclerosis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55708-1_6

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  • DOI: https://doi.org/10.1007/978-4-431-55708-1_6

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  • Print ISBN: 978-4-431-55707-4

  • Online ISBN: 978-4-431-55708-1

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