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Systemic Sclerosis

  • Book
  • © 2016

Overview

Editors:
  1. Kazuhiko Takehara

    1. Department of Dermatology, Kanazawa University, Kanazawa, Japan

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  2. Manabu Fujimoto

    1. Department of Dermatology, University of Tsukuba, Tsukuba, Japan

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  3. Masataka Kuwana

    1. Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan

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  • Provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma)

  • Presents a variety of new evidence suggestive of the pathogenesis of scleroderma

  • Covers clinical research regarding biomarkers and autoantibodies for scleroderma

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. Fibrosis: Overview

    • Hironobu Ihn
    Pages 1-20

  3. Autoimmunity in Systemic Sclerosis: Overview

    • Ayumi Yoshizaki, Shinichi Sato
    Pages 21-37

  4. Endothelial Progenitor Cells

    • Masataka Kuwana
    Pages 39-56

  5. Animal Models of Systemic Sclerosis

    • Toshiyuki Yamamoto
    Pages 57-79

  6. Genetics of Systemic Sclerosis

    • Naoyuki Tsuchiya, Aya Kawasaki
    Pages 81-92

  7. Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis

    • Yasushi Kawaguchi
    Pages 93-102

  8. Interleukin-6 in the Pathogenesis of Systemic Sclerosis

    • Yoshihito Shima
    Pages 103-115

  9. Epigenetics

    • Masatoshi Jinnin
    Pages 117-136

  10. Transforming Growth Factor-ß and Connective Tissue Growth Factor

    • Manabu Fujimoto, Kazuhiko Takehara
    Pages 137-153

  11. Endothelin

    • Sei-ichiro Motegi
    Pages 155-171

  12. The Role of B Cells in Systemic Sclerosis

    • Takashi Matsushita, Kazuhiko Takehara
    Pages 173-185

  13. Fli1

    • Yoshihide Asano
    Pages 187-209

  14. Biomarker

    • Minoru Hasegawa
    Pages 211-229

  15. Autoantibodies in Systemic Sclerosis

    • Yasuhito Hamaguchi
    Pages 231-247
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Keywords

About this book

This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.

Editors and Affiliations

  • Department of Dermatology, Kanazawa University, Kanazawa, Japan

    Kazuhiko Takehara

  • Department of Dermatology, University of Tsukuba, Tsukuba, Japan

    Manabu Fujimoto

  • Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan

    Masataka Kuwana

About the editors

Dr. Kazuhiko Takehara
Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan

Dr. Manabu Fujimoto
Department of Dermatology, University of Tsukuba, Japan

Dr. Masataka Kuwana
Department of Allergy and Rheumatology, Nippon Medical School, Japan

Bibliographic Information

  • Book Title: Systemic Sclerosis

  • Editors: Kazuhiko Takehara, Manabu Fujimoto, Masataka Kuwana

  • DOI: https://doi.org/10.1007/978-4-431-55708-1

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Japan 2016

  • Hardcover ISBN: 978-4-431-55707-4Published: 16 February 2016

  • Softcover ISBN: 978-4-431-56680-9Published: 31 March 2018

  • eBook ISBN: 978-4-431-55708-1Published: 04 February 2016

  • Edition Number: 1

  • Number of Pages: VIII, 247

  • Number of Illustrations: 7 b/w illustrations, 21 illustrations in colour

  • Topics: Dermatology, Rheumatology, Internal Medicine

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