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Arterial Spin Labeling in Dementia

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Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias

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Abstract

Arterial spin labeling (ASL) is a type of MR perfusion imaging which utilizes magnetically labeled arterial blood as an intrinsic tracer. Because ASL involves no radioactive tracers or contrast administration, it is considered to be completely noninvasive. Moreover, ASL theoretically allows for quantitative measurement of regional cerebral blood flow (rCBF). However, ASL suffers from technical limitations including low signal-to-noise ratio and high sensitivity to arterial transit time inhomogeneity. A variety of ASL pulse sequences have been proposed, which are categorized into pulsed ASL and continuous ASL sequences. Maps of rCBF obtained with ASL are typically analyzed quantitatively, often using image statistical methods. Typical ASL findings of Alzheimer’s disease include hypoperfusion in the cortical areas of the posterior cingulate and precuneus as well as the temporoparietal association cortex. Several studies have shown that ASL has high diagnostic performance in discriminating patients with Alzheimer’s disease and healthy elderly subjects, although its clinical roles in diagnosing dementia have not been established.

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Authors and Affiliations

  1. Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan

    Takashi Yoshiura

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  1. Takashi Yoshiura
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Correspondence to Takashi Yoshiura .

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Editors and Affiliations

  1. Integrative Brain Imaging Center, National Center of Neurology & Psychiatry, Kodaira, Tokyo, Japan

    Hiroshi Matsuda

  2. Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

    Takashi Asada

  3. Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan

    Aya Midori Tokumaru

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Yoshiura, T. (2017). Arterial Spin Labeling in Dementia. In: Matsuda, H., Asada, T., Tokumaru, A. (eds) Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55133-1_6

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  • DOI: https://doi.org/10.1007/978-4-431-55133-1_6

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  • Print ISBN: 978-4-431-55132-4

  • Online ISBN: 978-4-431-55133-1

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