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Possible Mechanism of Vasogenic Brain Oedema Induced by Arachidonic Acid

  • Conference paper
Brain Edema VIII

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 51))

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Summary

Free archidonic acid was infused into normal rat brains and the effect of arachidonic acid on capillary permeability was investigated by measuring the regional uptake of 14C-aminoisobutyric acid with a quantitative autoradiographic method. Arachidonic acid increased capillary permeability in a dose-dependent manner up to 2 mM. A high dose of arachidonic acid ( > 5 mM) produced a profound tissue destruction around the needle track and less increased capillary permeability than 2 mM arachidonic acid. Time-course study disclosed that arachidonic acid markedly increased capillary permeability within 2 hours after infusion, and continued to increase with time to 24 hours. The effect of 48 hours infusion was about a half of that at 24 hours, indicating that the effect of arachidonic acid was partially reversible. Pretreatment with dexamethasone significantly inhibited the arachidonic acid-induced increase in capillary permeability and the administration of actinomycin D 1 hour before the pretreatment with dexamethasone suppressed the inhibitory effect of dexamethasone. These results suggest that arachidonic acid, which is deposited in the extracellular space, increases brain capillary permeability by two different ways. One is the direct detergent effect of arachidonic acid, and the other is the effect of arachidonic acid that is released from the membrane by the activation of phospholipase A2.

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References

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan

    H. Iwasaki & T. Hayakawa

  2. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA

    W. R. Shapiro

  3. Department of Neurosurgery, Osaka University Medical School, 1-1-50 Fukushima, Fukushima, Osaka 553, Japan

    T. Ohnishi M.D.

Authors
  1. T. Ohnishi M.D.
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  2. H. Iwasaki
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  3. T. Hayakawa
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  4. W. R. Shapiro
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Bern, Switzerland

    Hans-J. Reulen

  2. Institut für chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Alexander Baethmann

  3. Department of Neurological Surgery, State University of New York at Stony Brook, New York, USA

    Joseph Fenstermacher

  4. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland, USA

    Maria Spatz

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© 1990 Springer-Verlag

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Ohnishi, T., Iwasaki, H., Hayakawa, T., Shapiro, W.R. (1990). Possible Mechanism of Vasogenic Brain Oedema Induced by Arachidonic Acid. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_22

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  • DOI: https://doi.org/10.1007/978-3-7091-9115-6_22

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9117-0

  • Online ISBN: 978-3-7091-9115-6

  • eBook Packages: Springer Book Archive

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