Summary
In a previous study, the daily urinary excretion of total (R + S) salsolinol was shown to be significantly lower in de novo parkinsonian patients than in healthy volunteers.
Here, we report on the urinary concentrations and daily urinary excretion of (R)- and (S)-salsolinol in an additional sample of 12 healthy subjects and 9 de novo parkinsonians. The urinary concentrations of both enantiomers of salsolinol were lower than the limit of detection in the urine of the parkinsonians. (R)-Salsolinol was detectable in the urine of 8 healthy subjects, whereas (S)-salsolinol was detectable in the urine of 3 only. Since 1,2-dehydrosalsolinol was present in the urine of parkinsonian patients, it is suggested that salsolinol bioprecursors such as 1,2-dehydrosalsolinol and 1-carboxysalsolinol might be additional markers for the early detection of Parkinson’s disease.
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© 1990 Springer-Verlag/Wien
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Dostert, P., Strolin Benedetti, M., Dordain, G. (1990). Salsolinol and the early detection of Parkinson’s disease. In: Dostert, P., Riederer, P., Strolin Benedetti, M., Roncucci, R. (eds) Early Markers in Parkinson’s and Alzheimer’s Diseases. New Vistas in Drug Research, vol 1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9098-2_11
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DOI: https://doi.org/10.1007/978-3-7091-9098-2_11
Publisher Name: Springer, Vienna
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