Summary
Salsolinol is present in human fluids and tissues as well as in foods and beverages. It was shown previously that the R enantiomer of salsolinol predominates in human urine, whereas the S enantiomer predominates in Port wine. An R/S ratio very near to 1 was found in dried banana, a food particularly rich in salsolinol.
In this study 100 g of dried banana were administered to 6 healthy subjects. The urinary excretion of the R and S enantiomers of salsolinol was measured 24 h before and 24 h after banana intake, each time in two fractions. Whereas the S enantiomer was present only in the fraction 5 p.m.–9 a.m. and only in 3 out of the 6 subjects before banana intake, this enantiomer was found in the two intervals 9 a.m.–5 p.m. and 5 p.m.–9 a.m. in all the subjects after banana intake. The presence of the S enantiomer in urine in 3 subjects before dried banana might be related to alcohol intake. The amount of R + S salsolinol eliminated in the 24 h urine was found to represent 0.75% of the total dose administered. In conclusion a normal diet should have a negligible influence on urinary salsolinol concentrations, with, perhaps, the exception of alcohol; interestingly the R enantiomer might represent endogenous salsolinol.
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Strolin Benedetti, M., Dostert, P. & Carminati, P. Influence of food intake on the enantiomeric composition of urinary salsolinol in man. J. Neural Transmission 78, 43–51 (1989). https://doi.org/10.1007/BF01247112
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DOI: https://doi.org/10.1007/BF01247112