Summary
In a previous study, the daily urinary excretion of total (R + S) salsolinol was shown to be significantly lower in de novo parkinsonian patients than in healthy volunteers.
Here, we report on the urinary concentrations and daily urinary excretion of (R)- and (S)-salsolinol in an additional sample of 12 healthy subjects and 9 de novo parkinsonians. The urinary concentrations of both enantiomers of salsolinol were lower than the limit of detection in the urine of the parkinsonians. (R)-Salsolinol was detectable in the urine of 8 healthy subjects, whereas (S)-salsolinol was detectable in the urine of 3 only. Since 1,2-dehydrosalsolinol was present in the urine of parkinsonian patients, it is suggested that salsolinol bioprecursors such as 1,2-dehydrosalsolinol and 1-carboxysalsolinol might be additional markers for the early detection of Parkinson’s disease.
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References
Brossi A (1982) Mammalian TIQ’s: products of condensation with aldehydes or pyruvic acid? Prog Clin Biol Res 90: 123–133
Dordain G, Dostert P, Strolin Benedetti M, Rovei V (1984) Tetrahydroisoquinoline derivatives and parkinsonism. In: Tipton KF, Dostert P, Strolin Benedetti M (eds) Monoamine oxidase and disease. Prospects for therapy with reversible inhibitors. Academic Press, London, pp 417–426
Dostert P, Strolin Benedetti M, Dedieu M (1987) Ratio of enantiomers of salsolinol in human urine. Pharmacol Toxicol 60 [Suppl 1]: 13
Dostert P, Strolin Benedetti M, Bellotti V, Allievi C, Dordain G (1990) Biosynthesis of salsolinol, a tetrahydroisoquinoline alkaloid, in healthy subjects. J Neural Transm 81: 215–223
Pianezzola E, Bellotti V, Fontana E, Moro E, Gal J, Desai DM (1989) Determination of the enantiomeric composition of salsolinol in biological samples by high-performance liquid chromatography with electrochemical detection. J Chromatogr Biomed Appl 495: 205–214
Robbins JH (1968) Possible alkaloid formation in alcoholism and other diseases. Clin Res 16: 554
Sandler M, Bonham Carter S, Hunter KR, Stern GM (1973) Tetrahydroisoquinoline alkaloids: in vivo metabolites of L-dopa in man. Nature 241: 439–443
Strolin Benedetti M, Bellotti V, Pianezzola E, Moro E, Carminati P, Dostert P (1989a) Ratio of the R and S enantiomers of salsolinol in food and human urine. J Neural Transm 77: 47–53
Strolin Benedetti M, Dostert P, Carminati P (1989b) Influence of food intake on the enantiomeric composition of urinary salsolinol in man. J Neural Transm [Gen Sect] 78: 43–51
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© 1990 Springer-Verlag/Wien
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Dostert, P., Strolin Benedetti, M., Dordain, G. (1990). Salsolinol and the early detection of Parkinson’s disease. In: Dostert, P., Riederer, P., Strolin Benedetti, M., Roncucci, R. (eds) Early Markers in Parkinson’s and Alzheimer’s Diseases. New Vistas in Drug Research, vol 1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9098-2_11
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DOI: https://doi.org/10.1007/978-3-7091-9098-2_11
Publisher Name: Springer, Vienna
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