Skip to main content
SpringerLink
Log in

New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer

  • Chapter
  • First Online:
Sphingolipids in Disease

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 216))

Abstract

In this chapter, we review the latest developments concerning the role of sphingosine 1-phosphate (S1P) in cancer. Particular focus is paid to the role of sphingosine kinases 1 and 2, S1P lyase and S1P-dependent signalling networks in both solid tumours and haematological cancer. The potential of this S1P-dependent pathophysiology as a therapeutic target for the treatment of cancer is also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S (2010) Sphingosine 1-phosphate is a missing co-factor for the E3 ligase TRAF2. Nature 465:1084–1088

    Article  PubMed  CAS  Google Scholar 

  • Antoon JW, White MD, Meacham WD, Slaughter EM, Muir SE, Elliott S, Rhodes LV, Ashe HB, Wiese TE, Smith CD, Burow ME, Beckman BS (2010) Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640. Endocrinology 151:5124–5135

    Article  PubMed  CAS  Google Scholar 

  • Antoon JW, Meacham WD, Bratton MR, Slaughter EM, Rhodes LV, Ashe HB, Wiese TE, Burow ME, Beckman BS (2011) Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signalling in human breast cancer. J Mol Endocrinol 46:205–216

    Article  PubMed  CAS  Google Scholar 

  • Arnold HK, Sears RC (2008) A tumor suppressor role for PP2A–alpha through negative regulation of c-Myc and other key oncoproteins. Cancer Metastasis Rev 27:147–158

    Article  PubMed  CAS  Google Scholar 

  • Azuma H, Takahara S, Ichimaru N, Wang JD, Itoh Y, Otsuki Y, Morimoto J, Fukui R, Hoshiga M, Ishihara T, Nonomura N, Suzuki S, Okuyama A, Katsuoka Y (2002) Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Res 62:1410–1419

    PubMed  CAS  Google Scholar 

  • Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B (2007) Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib induced apoptosis in K562 human chronic myeloid lekaemia cells. J Biol Chem 282:10922–10934

    Article  Google Scholar 

  • Barr RK, Lynn HE, Moretti PA, Khew-Goodall Y, Pitson SM (2008) Deactivation of sphingosine kinase 1 by protein phosphatase 2A. J Biol Chem 283:34994–35002

    Article  PubMed  CAS  Google Scholar 

  • Beljanski V, Knaak C, Smith CD (2010) A novel sphingosine kinase inhibitor induces autophagy in tumour cells. J Pharmacol Exp Ther 333:454–464

    Article  PubMed  CAS  Google Scholar 

  • Bonhoure E, Lauret A, Barnes DJ, Martin C, Malavaud B, Kohama T, Melo JB, Cuvillier O (2008) Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukaemia cells. Leukemia 22:971–979

    Article  PubMed  CAS  Google Scholar 

  • Colié S, Van Veldhoven PP, Kedjouar B, Bedia C, Albinet V, Sorli SC, Garcia V, Djavaheri-Mergny M, Bauvy C, Codogno P, Levade T, Andrieu-Abadie N (2009) Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res 69:9346–9353

    Article  PubMed  Google Scholar 

  • Dickson MA, Carvajal RD, Merrill AH Jr, Gonen M, Cane LM, Schwartz GK (2011) A phase I clinical trial of safingol in combination with Cisplatin in advanced solid tumours. Clin Cancer Res 17:2484–2492

    Article  PubMed  CAS  Google Scholar 

  • Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356:215–221

    Article  PubMed  CAS  Google Scholar 

  • Fisher KE, Pop A, Koh W, Anthis NJ, Saunders WB, Davis GE (2006) Tumour cell invasion of collagen matrices requires coordinate lipid agonist-induced G protein and membrane-type matrix metalloproteinase-1-dependent signalling. Mol Cancer 5:69

    Article  PubMed  Google Scholar 

  • French KJ, Schrecengost RS, Lee BD, Zhuang Y, Smith SN, Eberly JLM, Yun JK, Smith CD (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res 63:5962–5969

    PubMed  CAS  Google Scholar 

  • French KJ, Zhuang Y, Maines LW, Gao P, Wang W, Beljanski V, Upson JJ, Green CL, Keller SN, Smith CD (2010) Pharmacology and antitumour activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther 333:129–139

    Article  PubMed  CAS  Google Scholar 

  • Gao P, Smith CD (2011) Ablation of sphingosine kinase-2 inhibits tumour cell proliferation and migration. Mol Cancer Res 9(11):1509–19

    Article  PubMed  CAS  Google Scholar 

  • Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S (2009) Regulation of histone acetylation in the nucleus by sphingosine 1-phosphate. Science 325:1254–1257

    Article  PubMed  CAS  Google Scholar 

  • Heffernan-Stroud LA, Helke KL, Jenkins RW, De Costa AM, Hannum YA, Obeid LM (2011) Defining a role for sphingosine kinase 1 in p53-dependent tumours. Oncogene 31(9):1166–75

    Article  PubMed  Google Scholar 

  • Huwlier A, Kotelevets N, Xin C, Pastukhov O, Pfeilschiffter J, Zangemeister-Wittke U (2011) Loss of sphingosine kinase 1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage. Br J Pharmacol 162:532–543

    Article  Google Scholar 

  • Ito H, Yoshida K, Murakami M, Hagiwara K, Sasaki N, Kobayashi M, Takagi A, Kojima T, Sobue S, Suzuki M, Tamiya-Koizumi K, Nakamura M, Banno Y, Nozawa Y, Murate T (2011) Heterogeneous sphingosine-1-phosphate lyase gene expression and its regulatory mechanism in human lung cancer cell lines. Biochim Biophys Acta 1811:119–128

    Article  PubMed  CAS  Google Scholar 

  • Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA (1994) Tumour spectrum analysis in p53-mutant mice. Curr Biol 4:1–7

    Article  PubMed  CAS  Google Scholar 

  • Kapitonov D, Allegood JC, Mitchell C, Hait NC, Almenara JA, Adams JK, Zipkin RE, Dent P, Kordula T, Milstien S, Spiegel S (2009) Targeting sphingosine kinase 1 inhibits AKT signalling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res 69:6915–6923

    Article  PubMed  CAS  Google Scholar 

  • Kennedy AJ, Mathews TP, Kharel Y, Field SD, Moyer ML, East JE, Houck JD, Lynch KR, Macdonlad TL (2011) Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. J Med Chem 54:3524–3548

    Article  PubMed  CAS  Google Scholar 

  • Kilbey A, Terry A, Jenkins A, Borland G, Zhang Q, Wakelam MJ, Cameron ER, Neil JC (2010) Runx regulation of sphingolipid metabolism and survival signalling. Cancer Res 70:5860–5869

    Article  PubMed  CAS  Google Scholar 

  • Kono K, Tanaka M, Ogita T, Kohama T (2000a) Characterisation of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium. J Antibiot (Tokyo) 53:759–764

    Article  CAS  Google Scholar 

  • Kono K, Tanaka M, Ogita T, Hosoya T, Koyama T (2000b) F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete. J Antibiot (Tokyo) 53:459–466

    Article  CAS  Google Scholar 

  • Kono K, Tanaka M, Ono Y, Hosoya T, Ogita T, Kohama T (2001) S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus. J Antibiot (Tokyo) 54:415–420

    Article  CAS  Google Scholar 

  • Leclercq TM, Moretti PA, Pitson SM (2011) Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis. Oncogene 30:372–378

    Article  PubMed  CAS  Google Scholar 

  • Lee H, Deng J, Kujawski M, Yang C, Liu Y, Herrmann A, Kortylewski M, Horne D, Somlo G, Forman S, Jove R, Yu H (2010) STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med 16:1421–1428

    Article  PubMed  CAS  Google Scholar 

  • Li QF, Huang WR, Duan HF, Wang H, Wu CT, Wang LS (2007) Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells. Oncogene 26:7904–7908

    Article  PubMed  CAS  Google Scholar 

  • Lim KG, Tonelli F, Li Z, Lu X, Bittman R, Pyne S, Pyne NJ (2011a) FTY720 analogues as sphingosine kinase 1 inhibitors: Enzyme inhibition kinetics, allosterism, proteasomal degradation and actin rearrangement in MCF-7 breast cancer cells. J Biol Chem 286:18633–18640

    Article  PubMed  CAS  Google Scholar 

  • Lim KG, Sun C, Bittman R, Pyne NJ, Pyne S (2011b) (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal 23:1590–1595

    Article  PubMed  CAS  Google Scholar 

  • Liu H, Toman RE, Goparaju SK, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, Spiegel S (2003) Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem 278:40330–40336

    Article  PubMed  CAS  Google Scholar 

  • Liu Q, Zhao X, Frissora F, Ma Y, Santhanam R, Jarjoura D, Lehman A, Perrotti D, Chen CS, Dalton JT, Muthusamy N, Byrd JC (2008) FTY720 demonstrates promising pre-clinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood 111:275–284

    Article  PubMed  CAS  Google Scholar 

  • Long JS, Edwards J, Watson C, Tovey S, Mair K, Schiff R, Natarajan V, Pyne NJ, Pyne S (2010a) Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor positive breast cancer cells. Mol Cell Biol 30:3827–3841

    Article  PubMed  CAS  Google Scholar 

  • Long JS, Fujiwara Y, Edwards J, Tannahill C, Tigyi G, Pyne S, Pyne NJ (2010b) Sphingosine 1-phosphate 4 uses HER2 (ErbB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. J Biol Chem 285:35957–35966

    Article  PubMed  CAS  Google Scholar 

  • Loveridge C, Tonelli F, Leclecq T, Lim KG, Long S, Berdyshev E, Tate RJ, Natarajan V, Pitson SM, Pyne NJ, Pyne S (2010) The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. J Biol Chem 285:38841–38852

    Article  PubMed  CAS  Google Scholar 

  • Lozano G (2010) Mouse models of p53 functions. Cold Spring Harb Perspect Biol 2(4):a001115

    Article  PubMed  Google Scholar 

  • Marfe G, Di Stefano C, Gambacurta A, Ottone T, Martini V, Abruzzese E, Mologni L, Sinibaldi-Salimei P, de Fabritis P, Gambacorti-Passerini C, Amadori S, Birge RB (2011) Sphingosine kinase 1 overexpression is regulated by signalling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells. Exp Hematol 39:653–665.e6

    Article  PubMed  CAS  Google Scholar 

  • Neviani P, Santhanam R, Trotta R, Notari M, Blaser BW, Liu S, Mao H, Chang JS, Galietta A, Uttam A, Roy DC, Valtieri M, Bruner-Klisovic R, Caligiuri MA, Bloomfield CD, Marcucci G, Perrotti D (2005) The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell 8:355–368

    Article  PubMed  CAS  Google Scholar 

  • Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, Blaser BW, Liu S, Trotta R, Muthusamy N, Gambacorti-Passerini C, Druker BJ, Cortes J, Marcucci G, Chen C-S, Verrills NM, Roy DC, Caligiuri MA, Bloomfield CD, Byrd JC, Perrotti D (2007) FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphocytic leukemia. J Clin Invest 117:2408–2421

    Article  PubMed  CAS  Google Scholar 

  • Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS (2011) Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology 53:1943–1958

    Article  PubMed  CAS  Google Scholar 

  • Pchejetski D, Bohler T, Brizuela L, Sauer L, Doumerc N, Golzio M, Salunkhe V, Teissié J, Malavaud B, Waxman J, Cuvillier O (2010) FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1. Cancer Res 70:8651–8661

    Article  PubMed  CAS  Google Scholar 

  • Pitman MR, Barr RK, Gliddon BL, Magarey AM, Moretti PA, Pitson SM (2011) A critical role for the protein phosphatase 2A B’alpha regulatory subunit in dephosphorylation of sphingosine kinase 1. Int J Biochem Cell Biol 43:342–347

    Article  PubMed  CAS  Google Scholar 

  • Pitson SM, Moretti PA, Zebol JR, Lynn HE, Xia P, Vadas MA, Wattenberg BW (2003) Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO J 22:5491–5500

    Article  PubMed  CAS  Google Scholar 

  • Pyne S, Pyne NJ (2000) Sphingosine 1-phosphate signalling in mammalian cells. Biochem J 349:385–402

    Article  PubMed  CAS  Google Scholar 

  • Pyne NJ, Pyne S (2010) Sphingosine 1-phosphate and cancer. Nat Rev Cancer 10:489–503

    Article  PubMed  CAS  Google Scholar 

  • Pyne S, Lee SC, Long J, Pyne NJ (2009) Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell Signal 21:14–21

    Article  PubMed  CAS  Google Scholar 

  • Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, Baran Y, Mahajan S, Fernandes D, Stuart R, Perrotti D, Ogretmen B (2011) Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr/Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood 117:5941–5952

    Article  PubMed  CAS  Google Scholar 

  • Sankala HM, Hait NC, Paugh SW, Shida D, Lépine S, Elmore LW, Dent P, Milstien S, Spiegel S (2007) Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res 67:10466–10474

    Article  PubMed  CAS  Google Scholar 

  • Shida D, Kitayama J, Yamaguchi H, Yamashita H, Mori K, Watanabe T, Nagawa H (2005) Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells. Biochem Biophys Res Commun 327:907–914

    Article  PubMed  CAS  Google Scholar 

  • Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T (2011) A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prev Res 4:454–462

    Article  CAS  Google Scholar 

  • Sobue S, Nemoto S, Murakami M, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Nakamura M, Ito Y, Suzuki M, Banno Y, Nozawa Y, Murati T (2008) Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukaemia cells. Int J Haematol 87:266–275

    Article  CAS  Google Scholar 

  • Sukocheva O, Wadham C, Holmes A, Albanese N, Verrier E, Feng F, Bernal A, Derian CK, Ullrich A, Vadas MA, Xia P (2006) Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. J Cell Biol 173:301–310

    Article  PubMed  CAS  Google Scholar 

  • Taha TA, Osta W, Kozhaya L, Bielawski J, Johnson KR, Gillanders WE, Dbaibo GS, Hannun YA, Obeid LM (2004) Downregulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem 279:20546–20554

    Article  PubMed  CAS  Google Scholar 

  • Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ (2010) FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell Signal 22:1536–1542

    Article  PubMed  CAS  Google Scholar 

  • Valentine WJ, Kiss GN, Liu J, Gotoh M, Murakami-Murofushi K, Pham TC, Baker DL, Parrill AL, Lu X, Sun C, Bittman R, Pyne NJ, Tigyi G (2010) (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, signals as a pan-antagonist of sphingosine 1-phosphate GPCR and inhibits autotaxin activity. Cell Signal 22:1543–1553

    Article  PubMed  CAS  Google Scholar 

  • Van Brocklyn JR, Jackson CA, Pearl DK, Kotur MS, Snyder PJ, Prior TW (2005) Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: role of sphingosine kinase isoforms in growth of glioblastoma cell lines. J Neuropathol Exp Neurol 64:695–705

    Article  PubMed  Google Scholar 

  • Wallington-Beddoe CT, Hewson J, Bradstock KF, Bendall LJ (2011) FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy 7:707–715

    Article  PubMed  CAS  Google Scholar 

  • Watson C, Long JS, Orange C, Tannahill CL, Mallon E, McGlynn LM, Pyne S, Pyne NJ, Edwards J (2010) High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. Am J Pathol 177:2205–2215

    Article  PubMed  CAS  Google Scholar 

  • Xia P, Gamble JR, Wang L, Pitson SM, Moretti PA, Wattenberg BW, D’Andrea RJ, Vadas MA (2000) An oncogenic role of sphingosine kinase. Curr Biol 10:1527–1530

    Article  PubMed  CAS  Google Scholar 

  • Yamashita H, Kitayama J, Shida D, Yamaguchi H, Mori K, Osada M, Aoki S, Yatomi Y, Takuwa Y, Nagawa H (2006) Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. J Surg Res 130:80–87

    Article  PubMed  CAS  Google Scholar 

  • Yasui H, Hideshima T, Raje N, Roccaro AM, Shiraishi N, Kumar S, Hamasaki M, Ishitsuka K, Tai YT, Podar K, Catley L, Mitsiades CS, Richardson PG, Albert R, Brinkmann V, Chauhan D, Anderson KC (2005) FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res 65:7478–7484

    Article  PubMed  CAS  Google Scholar 

  • Zhang N, Qi Y, Wadham C, Wang L, Warren A, Di W, Xia P (2010) FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. Autophagy 6:1157–1167

    Article  PubMed  CAS  Google Scholar 

  • Zheng T, Meng X, Wang JB, Chen X, Yin D, Liang Y, Song X, Pan S, Jiang H, Liu L (2010) PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. J Cell Biochem 111:218–228

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cell Biology Group, SIPBS, University of Strathclyde, 161 Cathedral St, Glasgow, UK

    Susan Pyne & Nigel J. Pyne

Authors
  1. Susan Pyne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nigel J. Pyne
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Susan Pyne or Nigel J. Pyne .

Editor information

Editors and Affiliations

  1. , Department of Molecular Biology, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45122, Germany

    Erich Gulbins

  2. Division of Pulmonary, Allergy, Critical, Department of Medicine, Indiana University School of Medicine, W. Walnut Street 980, Indianapolis, 46202, Indiana, USA

    Irina Petrache

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Wien

About this chapter

Cite this chapter

Pyne, S., Pyne, N.J. (2013). New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer. In: Gulbins, E., Petrache, I. (eds) Sphingolipids in Disease. Handbook of Experimental Pharmacology, vol 216. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1511-4_3

Download citation

Publish with us

Policies and ethics

Search

Navigation