Abstract
With few exceptions all tissues in the mammalian body are invested by a highly branched microcirculatory network. The microcirculation serves to bring the blood into close contact with every part of the tissue. In this way the exchange between blood and tissue of oxygen, nutrients, metabolic bi-products, etc. can be bridged efficiently by diffusion. Like most other hollow structures in the body, the wall of arterioles and small muscular arteries (resistance vessels) are invested with a specific kind of contractile cell known as the smooth muscle cell(SMC). The SMC is long and spindle shaped. Under the microscope its interior does not appear as highly organized as, for instance, the cells of skeletal muscle tissue. In the latter kind of cells the structure of the contractile machinery can be directly observed, but this is not the case for the SMC. In addition, contraction or relaxation of the SMC is involuntary, i.e. we cannot control it by will. For a number of reasons, however, the contractile characteristics of the SMC make it well suited to participate in the regulation of our internal milieu.
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References
Aalkjaer C, Danielsen H, Johannesen P, Pedersen EB, Rasmussen A, Mulvany MJ (1985) Abnormal vascular function and morphology in pre-eclampsia: a study of isolated resistance vessels. Clin Sci (Lond) 69:477–482
Boegehold MA (1993) Enhanced arteriolar vasomotion in rats with chronic salt-induced hypertension. Microvasc Res 45:83–94
Bolton TB, Gordienko DV (1998) Calcium homeostasis - Confocal imaging of calcium release events in single smooth muscle cells. Acta Physiol Scand 164:567–575
Bouskela E, Grampp W (1992) Spontaneous vasomotion in hamster cheek pouch arterioles in varying experimental conditions. Am J Physiol 262:H478–H485
Bouskela E, Wiederhielm CA (1979) Microvascular myogenic reaction in the wing of the intact unanesthetized bat 3. Am J Physiol 237:H59–H65
Colantuoni A, Bertuglia S, Intaglietta M (1984) Quantitation of rhythmic diameter changes in arterial microcirculation. Am J Physiol 246:H508–H517
Colantuoni A, Bertuglia S, Intaglietta M (1984) The effects of alpha- or beta-adrenergic receptor agonists and antagonists and calcium entry blockers on the spontaneous vasomotion. Microvasc Res 28:143–158
D’Agrosa LS (1970) Patterns of venous vasomotion in the bat wing. Am J Physiol 218: 530–535
De Young GW, Keizer J (1992) A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2 + concentration. Proc Natl Acad Sci USA 89:9895–9899
Fujii K, Heistad DD, Faraci FM (1990) Vasomotion of basilar arteries in vivo. Am J Physiol 258:H1829–H1834
Gustafsson H, Bulow A, Nilsson H (1994) Rhythmic contractions of isolated, pressurized small arteries from rat. Acta Physiol Scand 152:145–152
Gustafsson H, Mulvany MJ, Nilsson H (1993) Rhythmic contractions of isolated small arteries from rat: influence of the endothelium. Acta Physiol Scand 148:153–163
Gustafsson H, Nilsson H (1993) Rhythmic contractions of isolated small arteries from rat: role of calcium. Acta Physiol Scand 149:283–291
Imtiaz MS, Smith DW, van Helden DF (2002) A theoretical model of slow wave regulation using voltage-dependent synthesis of inositol 1,4,5-trisphosphate. Biophys J 83:1877–1890
Intaglietta M (1991) Arteriolar vasomotion: implications for tissue ischemia. Blood Vessels 28 Suppl 1:1–7
Jacobsen JC, Aalkjaer C, Matchkov VV, Nilsson H, Freiberg JJ, Holstein-Rathlou NH (2008) Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall. Philos Transact A Math Phys Eng Sci 366:3483–3502
Jacobsen JC, Aalkjaer C, Nilsson H, Matchkov VV, Freiberg J, Holstein-Rathlou NH (2007) A model of smooth muscle cell synchronization in the arterial wall. Am J Physiol Heart Circ Physiol 293:H229–H237
Jacobsen JC, Aalkjaer C, Nilsson H, Matchkov VV, Freiberg J, Holstein-Rathlou NH (2007) Activation of a cGMP-sensitive calcium-dependent chloride channel may cause transition from calcium waves to whole cell oscillations in smooth muscle cells. Am J Physiol Heart Circ Physiol 293:H215–H228
Knot HJ, Standen NB, Nelson MT (1998) Ryanodine receptors regulate arterial wall [Ca2+] and diameter in cerebral arteries of rat via KCa channels. J Physiol 508:1:211–221
Koenigsberger M, Sauser R, Lamboley M, Beny JL, Meister JJ (2004) Ca2 + dynamics in a population of smooth muscle cells: modeling the recruitment and synchronization. Biophys J 87:92–104
Koenigsberger M, Sauser R, Meister JJ (2005) Emergent properties of electrically coupled smooth muscle cells. Bull Math Biol 67:1253–1272
Laugesen JL, Mosekilde E, Holstein-Rathlou N-H (2011) C-type period-doubling transition in nephron autoregulation. Interface Focus 1:132–142
le Noble JL, Smith TL, Hutchins PM, Struyker-Boudier HA (1990) Microvascular alterations in adult conscious spontaneously hypertensive rats. Hypertension 15:415–419
Lee CH, Kuo KH, Dai J, van Breemen C (2005) Asynchronous calcium waves in smooth muscle cells. Can J Physiol Pharmacol 83:733–741
Lefer DJ, Lynch CD, Lapinski KC, Hutchins PM (1990) Enhanced vasomotion of cerebral arterioles in spontaneously hypertensive rats. Microvasc Res 39:129–139
Messmer K (1983) Vasomotion and Quantitative Capillaroscopy. Karger, Basel
Meyer JU, Lindbom L, Intaglietta M (1987) Coordinated diameter oscillations at arteriolar bifurcations in skeletal muscle. Am J Physiol 253:H568–H573
Oishi H, Schuster A, Lamboley M, Stergiopulos N, Meister JJ, Beny JL (2002) Role of membrane potential in vasomotion of isolated pressurized rat arteries. Life Sci 71:2239–2248
Osol G, Halpern W (1988) Spontaneous vasomotion in pressurized cerebral arteries from genetically hypertensive rats. Am J Physiol 254:H28–H33
Peng H, Matchkov V, Ivarsen A, Aalkjaer C, Nilsson H (2001) Hypothesis for the initiation of vasomotion. Circ Res 88:810–815
Rahman A, Matchkov V, Nilsson H, Aalkjaer C (2005) Effects of cGMP on coordination of vascular smooth muscle cells of rat mesenteric small arteries. J Vasc Res 42:301–311
Rucker M, Strobel O, Vollmar B, Roesken F, Menger MD (2000) Vasomotion in critically perfused muscle protects adjacent tissues from capillary perfusion failure. Am J Physiol Heart Circ Physiol 279:H550–H558
Sosnovtseva O, Pavlov A, Mosekilde E, Holstein-Rathlou N-H (2002) Bimodal oscillations in nephron autoregulation. Phys Rev E 66:6:61909-1-7
Sosnovtseva O, Pavlov A, Mosekilde E, Holstein-Rathlou N-H, Marsh DJ (2004) Double-wavelet approach to study frequency and amplitude modulation in renal autoregulation. Physical Review E 70:031915-1-031915-8
Ursino M, Cavalcanti S, Bertuglia S, Colantuoni A (1996) Theoretical analysis of complex oscillations in multibranched microvascular networks. Microvasc Res 51:229–249
Ursino M, Fabbri G (1992) Role of the myogenic mechanism in the genesis of microvascular oscillations (vasomotion): analysis with a mathematical model. Microvasc Res 43:156–177
Ursino M, Fabbri G, Belardinelli E (1992) A mathematical analysis of vasomotion in the peripheral vascular bed. Cardioscience 3:13–25
van Helden DF, Zhao J (2000) Lymphatic vasomotion. Clin Exp Pharmacol Physiol 27: 1014–1018
Zhao J, van Helden DF (2002) ATP-induced endothelium-independent enhancement of lymphatic vasomotion in guinea-pig mesentery involves P2X and P2Y receptors. Br J Pharmacol 137:477–487
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Jacobsen, J.C.B., Hald, B.O., Brasen, J.C., Holstein-Rathlou, NH. (2011). Synchronization of Cellular Contractions in the Arteriolar Wall. In: Mosekilde, E., Sosnovtseva, O., Rostami-Hodjegan, A. (eds) Biosimulation in Biomedical Research, Health Care and Drug Development. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0418-7_10
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