Biosimulation in Biomedical Research, Health Care and Drug Development

1. Front Matter

   Pages i-xv

   PDF

2. Modeling in Biomedical Research and Health Care

   • Steen G. Dawids, Jakob L. Laugesen, Erik Mosekilde

   Pages 1-18

3. Concepts in Mechanism Based Modeling

   • Ole Lund, Jakob L. Laugesen, Erik Mosekilde

   Pages 19-41

4. The Approach to Model Building

   • Jakob L. Laugesen, Erik Mosekilde

   Pages 43-68

5. Emergence of Oscillatory Dynamics

   • Jakob L. Laugesen, Erik Mosekilde

   Pages 69-95

6. Conductance-Based Models for the Evaluation of Brain Functions, Disorders, and Drug Effects

   • Svetlana Postnova, Christian Finke, Martin T. Huber, Karl Voigt, Hans A. Braun

   Pages 97-132

7. Functional Modeling of Neural-Glial Interaction

   • D. E. Postnov, N. A. Brazhe, O. V. Sosnovtseva

   Pages 133-151

8. Activity-Related Structural Changes in the Myelinated Nerve Fiber

   • Alexey R. Brazhe, Georgy V. Maksimov

   Pages 153-177

9. Closed-Loop Control of Brain Rhythms

   • Anne Beuter, Julien Modolo

   Pages 179-199

10. Modeling Ca2+ Microdomains

    • Jens Christian Brasen, Jens C. B. Jacobsen, Niels-Henrik Holstein-Rathlou

    Pages 201-218

11. Synchronization of Cellular Contractions in the Arteriolar Wall

    • Jens C. B. Jacobsen, Bjørn O. Hald, Jens C. Brasen, Niels-Henrik Holstein-Rathlou

    Pages 219-236

12. Microvascular Plasticity

    • Jens C. B. Jacobsen, Niels E. Olesen, Niels-Henrik Holstein-Rathlou

    Pages 237-252

13. Bifurcations and Multistability in Periodically Stimulated Cardiac Cells

    • Elena Surovyatkina

    Pages 253-284

14. Synchronization: A Case in Biological Studies

    • Olga V. Sosnovtseva, Dmitry E. Postnov, Natalia B. Janson, Alexander G. Balanov

    Pages 285-310

15. Multilevel-Modeling, Core Predictions, and the Concept of Final Conclusions

    • Elin Nyman, Peter Strålfors, Gunnar Cedersund

    Pages 311-328

16. Absorption Kinetics of Insulin Mixtures after Subcutaneous Administration

    • Christian Hove Rasmussen, Tue Søeborg, Erik Mosekilde, Morten Colding-Jørgensen

    Pages 329-359

17. Physiologically-Based Pharmacokinetics

    • Masoud Jamei, Karen R. Yeo, Trevor N. Johnson, Cyrus Ghobadi, Manoranjenni Chetty, Khaled Abduljalil et al.

    Pages 361-386

18. Back Matter

    Pages 387-396

    PDF

Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment.

This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic.

• Complex biological processes
• Mechanism based modeling
• Model-based drug development
• Model-based healtcare
• Systems biology

• , Department of Physics, Technical University of Denmark, Kongens Lyngby, Denmark

  Erik Mosekilde

• , Department of Biomedical Sciences, Copenhagen University, Copenhagen N, Denmark

  Olga Sosnovtseva

• , School of Pharmacy and Pharmaceutical Sc, University of Manchester, Manchester, United Kingdom

  Amin Rostami-Hodjegan

Erik Mosekilde was born in Århus, Denmark on May 26, 1941. In March 1966 he graduated (summa cum laude) from The Technical University of Denmark as an electrical engineer specialized in solid state physics, and in September 1968 he completed his Ph.D. studies at Physics Laboratory III with a thesis on acoustoelectric effects in piezoelectric semiconductors. Having performed his military service Erik Mosekilde was offered a postdoctoral position at Physics Laboratory III and shortly after received a postdoctoral fellowship from IBM, which allowed him to spend 9 months at Thomas J. Watson Research Center, Yorktown Heights, New York. In July 1972 Erik Mosekilde was appointed associate professor in modern physics, and in August 1977 he defended a dissertation on "Linear and Nonlinear Acoustoelectric Effects in Heavily Doped GaAs Epitaxial Single Crystals" for the Danish Doctor's degree at The University of Copenhagen. In September 2000 he was appointed Professor in Biological Applications of Nonlinear Dynamics at The Technical University of Denmark. Erik Mosekilde has been a member of various educational boards (1977-1982) and for six years (1982-1988) he was a member of Konsistorium, the governing body of The Technical University of Denmark. He has also served and as Vice President and member of the Policy Council for The System Dynamics Society (1984-1993), as member of the steering committee and chairman of the Scandinavian Simulation Society (1986-1992), as member of the Academic Advisory Group for the ERASMUS programme (1988-1990), as member of the J.W. Forrester Award Committee (1987-1997), as statistical consultant in medicine (1986-1998), as member of the steering committee for the Center for Chaos and Turbulence Studies, CATS (1992-2002), as chairman for the Center for Modeling, Nonlinear Dynamics and Irreversible Thermodynamics (1992-2006), as member of the steering committee for an EU COST-program on nonlinear dynamics in mechanical processing(1997-2001), as member of the steering committee for the Danish Graduate School in Nonlinear Science (1997-2002), as member of the steering committee for an INTAS program on coupled biological oscillators (2002-2005), as head of the Department of Physics (1996-2005), and as evaluator for a variety of national and international science foundations.

Policies and ethics