Abstract
Studying the mechanisms operative in the very earliest stage of a given disease is a difficult, and often even impossible task in the human situation. At this stage, clinical symptoms are not yet manifest and the patients-to-be have not yet consulted a physician. Experiments and analyses even before microscopically or biochemically sizable pathologic hallmarks emerge can therefore only be carried out in animal models. When such animal models are developed they can then allow for a chronological monitoring of pathogenetic events from morphologically and clinically unapparent to fully blown, often lethal stages of the disease under study.
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Wick, G., Buhr, N., Fraedrich, G., Grundtman, C. (2012). A Darwinian-Evolutionary Concept for Atherogenesis: The Role of Immunity to HSP60. In: Wick, G., Grundtman, C. (eds) Inflammation and Atherosclerosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0338-8_9
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