Abstract
The in vitro activity of ciprofloxacin against a wide range of bacterial isolates was assessed in comparison with norfloxacin, enoxacin, co-trimoxazole and penicillin (or ampicillin) where appropriate. Minimal inhibitory concentrations (MICs) indicated that ciprofloxacin was highly active against gram-negative bacilli of the Enterobacteriaceae and Pseudomonas groups, notably against strains resistant to gentamicin. Similarly, Staphylococcus aureus (including methicillin-resistant strains) and Haemophilus influenzae were susceptible, regardless of penicillinase production. Norfloxacin and enoxacin were less active than ciprofloxacin against the majority of species tested, although enoxacin blood levels were generally higher. Most co-trimoxazole-resistant strains were susceptible to the quinoline group of drugs.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Wise, R., Andrews, J. M., Edwards, L. J.: In vitro activity of Bay o 9867, a new quinoline derivative, compared with those of other antimicrobial agents. Antimicrobial Agents and Chemotherapy 1983, 23: 559–564.
Bauernfeind, A., Petermuller, C.: In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid. European Journal of Clinical Microbiology 1983, 2: 111–115.
Muytjens, H. L., van der Ros-van de Repe, J., van Veldhuizen, G.: Comparative activities of ciprofloxacin (Bay o 9867), norfloxacin, pipemidic acid, and nalidixic acid. Antimicrobial Agents and Chemotherapy 1983, 24: 302–304.
Corrado, M. L., Cherubin, C. E., Shulman, M.: The comparative activity of norfloxacin with other antimicrobial agents against gram-positive and gram-negative bacteria. Journal of Antimicrobial Chemotherapy 1983, 11: 369–376.
Kouno, K., Inoue, M., Mitsuhashi, S.: In vitro and in vivo antibacterial activity of AT-2266. Antimicrobial Agents and Chemotherapy 1983, 24: 78–84.
Boppana, V. K., Swanson, B. N.: Determination of norfloxacin, a new nalidixic acid analog, in human serum and urine by high performance liquid chromatography. Antimicrobial Agents and Chemotherapy 1982, 21: 808–810.
Saito, T., Yamad, Y., Arai, T.: Studies on AM-715: Biliary excretion, tissue concentrations in the liver and the gall bladder and clinical evaluation in the surgical field. Chemotherapy (Tokyo) 1981, 29, Supplement 4: 631–638.
Matsumuto, K., Suziki, FL, Tsuchihasi, K., Niyazaki, A., Shishido, H., Noguchi, Y., Watanabe, K.: Laboratory and clinical studies on AM-715. Chemotherapy (Tokyo) 1981, 29, Supplement 4: 370–379.
Rylander, M., Norrby, S. R.: Norfloxacin: penetration into subcutaneous tissue cage fluid in rabbits and in vivo efficacy. Antimicrobial Agents and Chemotherapy 1983, 23: 352–355.
Haase, D., Urias, B., Harding, G., Ronald, A.: Comparative in vitro activity of norfloxacin against urinary tract pathogens. European Journal of Clinical Microbiology 1983, 2: 235–241.
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1986 Springer Fachmedien Wiesbaden
About this chapter
Cite this chapter
Shrire, L., Saunders, J., Traynor, R., Kornhof, H.J. (1986). A Laboratory Assessment of Ciprofloxacin and Comparable Antimicrobial Agents. In: Neu, H.C., Reeves, D.S. (eds) Ciprofloxacin. Current Topics in Infectious Diseases and Clinical Microbiology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-01930-5_1
Download citation
DOI: https://doi.org/10.1007/978-3-663-01930-5_1
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
Print ISBN: 978-3-663-01931-2
Online ISBN: 978-3-663-01930-5
eBook Packages: Springer Book Archive