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In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid

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Abstract

The in vitro antibacterial activity of the new quinoline derivative ciprofloxacin (BAY 0 9867) was evaluated in comparison to norfloxacin and nalidixic acid using 495 clinical strains of gram-negative and gram-positive bacteria. The compound was highly active againstEnterobacteriaceae, with MICs ranging from 0.008 mg/l to 4 mg/l, whereas the MICs of norfloxacin ranged from 0.03 mg/l to 16 mg/l. All strains ofPseudomonas aeruginosa andAcinetobacter calcoaceticus were inhibited with a concentration of 2 mg/l ciprofloxacin and 32 mg/l norfloxacin. Ciprofloxacin was also active against gram-positive cocci. The MICs forStaphylococcusaureus, Staphylococcus epidermidis, andStreptococcus faecalis ranged from 0.008 to 2.0 mg/l. The activity of ciprofloxacin was only slightly influenced by inoculum size, whereas an acid environment caused a noticeable decrease in the activity. Ciprofloxacin would seem to be a promising antibacterial agent for the treatment of urinary tract infection.

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  1. Institute for Hygiene and Medical Microbiology, Munich University, Pettenkoferstr. 9a, 8000, Munich 2, FRG

    A. Bauernfeind & C. Petermüller

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  1. A. Bauernfeind
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  2. C. Petermüller
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Bauernfeind, A., Petermüller, C. In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid. Eur. J, Clin. Microbiol. 2, 111–115 (1983). https://doi.org/10.1007/BF02001575

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