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The Role of Biological Treatments in Spine Disorders

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Bio-orthopaedics

Abstract

This chapter addresses several aspects of spine disorders and their implications for pain, functional impairment, and their problems and treatments.

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References

  1. Atlas LY, Wager TD. How expectations shape pain. Neurosci Lett. 2012;520:140–8.

    Article  CAS  PubMed  Google Scholar 

  2. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152:S2–15.

    Article  PubMed  Google Scholar 

  3. Curatolo M, Uller M, Asharaf A, Neziri AY, Streitberger K, Andersen OK, Arendt-Nielsen L. Pain hypersensitivity and spinal nociceptive hypersensitivity in chronic pain: prevalence and associated factors. Pain. 2015;156:2373–82.

    Article  PubMed  Google Scholar 

  4. O’Neill S, Manniche C, Graven-Nielsen T, Arendt-Nielsen L. Generalized deep-tissue hyperalgesia in patients with chronic low-back pain. Eur J Pain. 2007;11:415–2.

    Article  PubMed  Google Scholar 

  5. Cervero F. Spinal cord hyperexcitability and its role in pain and hyperalgesia. Exp Brain Res. 2009;196:129–37.

    Article  PubMed  Google Scholar 

  6. Anzai H, Hamba M, Onda A, Konno S, Kikuchi S. Epidural application of nucleus pulposus enhancesnociresponses of rat dorsal horn neurons. Spine. 2002;27:E50–5.

    Article  PubMed  Google Scholar 

  7. Cuellar JM, Montesano PX, Carstens E. Role of TNF-alpha in sensitization of nociceptive dorsal horn neurons induced by application of nucleus pulposus to L5 dorsal root ganglion in rats. Pain. 2004;110:578–87.

    Article  CAS  PubMed  Google Scholar 

  8. Ahn SH, Cho YW, Ahn MW, Jang SH, Sohn YK, Kim HS. mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs. Spine. 2002;27:911–7.

    Article  PubMed  Google Scholar 

  9. Aoki Y, Rydevik B, Kikuchi S, Olmarker K. Local application of disc-related cytokines on spinal nerve roots. Spine. 2002;27:1614–7.

    Article  PubMed  Google Scholar 

  10. Grace PM, Hutchinson MR, Maier SF, Watkins LR. Pathological pain and the neuroimmune interface. Nat Rev Immunol. 2014;14:217–31.

    Article  CAS  PubMed  Google Scholar 

  11. Weber KT, Jacobsen TD, Maidhof R, Virojanapa J, Overby C, Bloom O, Chahine NO. Developments in intervertebral disc disease research: pathophysiology, mechanobiology and therapeutics. Curr Rev Muscoskelet Med. 2015;8:18–31.

    Article  Google Scholar 

  12. Tajeriana M, Clark JD. The role of the extracellular matrix in chronic pain following injury. Pain. 2015;156:366–70.

    Article  Google Scholar 

  13. Oray S, Majewska A, Sur M. Dendritic spine dynamics are regulated by monocular deprivation and extracellular matrix degradation. Neuron. 2004;44:1021–30.

    Article  CAS  PubMed  Google Scholar 

  14. Siniscalco D, Giordano C, Galderisi U, Luongo L, de Novellis V, Rossi F, Maione S. Long-lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviors, cellular, and biomolecular modifications in neuropathic mice. Front Integr Neurosci. 2011;5:79.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Spejo AB, Carvalho JL, Goes AM, Oliveira AL. Neuroprotective effects of mesenchymal stem cells on spinal motoneurons following ventral root axotomy: synapse stability and axonal regeneration. Neuroscience. 2013;250:715–32.

    Article  CAS  PubMed  Google Scholar 

  16. Torres-Espín A, Corona-Quintanilla DL, Forés J, Allodi I, González F, Udina E, Navarro X. Neuroprotection and axonal regeneration after lumbar ventral root avulsion by re-implantation and mesenchymal stem cells transplant combined therapy. Neurotherapeutics. 2013;10:354–68.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  17. Coronel MF, Musolino PL, Brumovsky PR, Hökfelt T, Villar MJ. Bone marrow stromal cells attenuate injury-induced changes in galanin, NPY and NPY Y1-receptor expression after a sciatic nerve constriction. Neuropeptides. 2009;43:125–32.

    Article  CAS  PubMed  Google Scholar 

  18. Labusca L, Zugun-Eloae L, Mashayekhi K. Stem cells for the treatment of musculoskeletal pain. World J Stem Cells. 2015;7:96–105.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Zhou Y, Warycha B, Vu H. Stem cell therapy: future of pain medicine. Br J Med Pract. 2014;7:728–30.

    Google Scholar 

  20. Hadjipavlou AG, Tzermiadianos MN, Bogduk N, Zindrick MR. The pathophysiology of disc degeneration. J Bone Joint Surg. 2008;90:1261–70.

    Article  CAS  Google Scholar 

  21. Thompson JP, Pearce RH, Schechter MT, Adams ME, Tsang IK, Bishop PB. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine. 1990;15:411–5.

    Article  CAS  PubMed  Google Scholar 

  22. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001;26:1873–8.

    Article  CAS  PubMed  Google Scholar 

  23. Thalgott JS, Albert TJ, Vaccaro AR, Aprill CN, Giuffre JM, Drake JS, Henke JP. A new classification system for degenerative disc disease of the lumbar spine based on magnetic resonance imaging, provocative discography, plain radiographs and anatomic considerations. Spine J. 2007;6:211–7.

    Google Scholar 

  24. Antoniou J, Steffen T, Nelson F, Winterbottom N, Hollander AP, Poole RA, Aebi M, Alini M. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degeneration. J Clin Invest. 1996;98:996–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Battié MC, Videman T. Lumbar disc degeneration: epidemiology and genetics. J Bone Joint Surg. 2006;88(A):S3–9.

    Google Scholar 

  26. Kapandji AI. Fisiologia articular. Tronco e coluna vertebral, vol III, 5th ed. São Paulo: Ed. Panamericana; 2000. p. 12–52.

    Google Scholar 

  27. Urban JPG, Roberts S, Ralphs JR. The nucleus of the intervertebral disc: from development to degeneration. Am Zool. 2000;40:53–61.

    Google Scholar 

  28. Urban PG, Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther. 2003;5:120–30.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine. 2006;31:2151–61.

    Article  PubMed  Google Scholar 

  30. Wallach CJ, Gilbertson LG, Kang JD. Gene therapy applications for intervertebral disc degeneration. Spine. 2003;28:592–8.

    Article  Google Scholar 

  31. Manek NJ, MacGregor AJ. Epidemiology of back disorders: prevalence, risk factor, and prognosis. Curr Opin Rheumatol. 2005;17:134–40.

    PubMed  Google Scholar 

  32. Roughley PJ. Biology of intervertebral disc aging and degeneration. Spine. 2004;29:2691–9.

    Article  PubMed  Google Scholar 

  33. Benneker LM, Heini PF, Alini M, Anderson SE, Ito K. Vertebral endplate marrow contact channel occlusions and intervertebral disc degeneration. Spine. 2005;30:167–73.

    Article  PubMed  Google Scholar 

  34. Urban JPG. The role of the physicochemical enviroment in determining disc cell behaviour. Biochem Soc Trans. 2002;30:858–63.

    Article  CAS  PubMed  Google Scholar 

  35. Bartels EM, Fairbank JCT, Winlove CP, Urban JPG. Oxigen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine. 1998;23:1–7.

    Article  CAS  PubMed  Google Scholar 

  36. Else MB, Fairbank JCT, Winlove CPD, Urban JPG. Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine. 1998;23:1–7.

    Article  Google Scholar 

  37. Cs-Szabo G, Ragasa-San Juan D, Turumella V, Masuda K, Thonar EJ, An HS. Changes in mRNA and protein levels of proteoglycans of the anulusfibrosus and nucleus pulposus during intervertebral disc degeneration. Spine. 2002;27:2212–9.

    Article  PubMed  Google Scholar 

  38. Kawaguchi Y, Osada R, Kanamori M, Ishihara H, Ohmori K, Matsui H, Kimura T. Association between an aggrecan gene polymorphism and lumbar disc degeneration. Spine (Phila Pa 1976). 1999;24(23):2456–60.

    Article  CAS  Google Scholar 

  39. Eisenstein SM, Roberts S. The physiology of the disc and its clinical relevance. J Bone Joint Surg Br. 2003;85-B:633–6.

    Google Scholar 

  40. Roberts S, Caterson B, Menage J, Evans EH, Jaffay DC, Eisenstein SM. Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc. Spine. 2000;25:3005–13.

    Article  CAS  PubMed  Google Scholar 

  41. Buckwalter JA. Aging and degeneration of the human intervertebral disc. Spine. 1995;20:1307–14.

    Article  CAS  PubMed  Google Scholar 

  42. Oegema Jr TR. The role of disc cell heterogeneity in determining disc biochemistry: a speculation. Biochem Soc Trans. 2002;30:839–44.

    Article  CAS  PubMed  Google Scholar 

  43. Adams MA, McNally DS, Dolan P. Intervertebral discs: the effects of age and degeneration. J Bone Joint Surg Br. 1996;78-B:965–72.

    Article  Google Scholar 

  44. Adams MA, Dolan P, Hutton WC. The stages of disc degeneration as reveled by discograms. J Bone Joint Surg Br. 1986;68-B:36–41.

    Google Scholar 

  45. Peng B, Hao J, Hou S, Wu W, Jiang D, Fu X, Yang Y. Possible pathogenesis of painful intervertebral disc degeneration. Spine. 2006;31:560–6.

    Article  PubMed  Google Scholar 

  46. Burke JG, Watson WG, Conhyea D, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM. Human nucleus pulposis can respond to a pro-inflammatory stimulus. Spine. 2003;28:2685–93.

    Article  CAS  PubMed  Google Scholar 

  47. Rudert M, Tillmann B. Detection of lymph and blood vessels in the human intervertebral disc by histochemical and immunohistochemical methods. Ann Anat. 1993;175:237–42.

    Article  CAS  PubMed  Google Scholar 

  48. Paesold G, Nerlich AG, Boos N. Biological treatment strategies for disc degeneration: potentials and shortcomings. Eur Spine J. 2007;16:447–68.

    Article  PubMed  Google Scholar 

  49. Yoon TS, Louis-Ugbo J. Molecular therapy of the intervertebral disc. Spine J. 2005;5:S280–6.

    Article  Google Scholar 

  50. Walsh AJL, Bradford DS, Lotz JC. In vivo growth factor treatment of degenerated intervertebral discs. Spine. 2004;29:156–63.

    Article  PubMed  Google Scholar 

  51. Gruber HE, Hanley Jr EN. Recent advances in disc cell biology. Spine. 2003;28:186–93.

    Article  PubMed  Google Scholar 

  52. Bellabarba C. Emerging spine surgery technologies: evidence and framework for evaluating new technology. J Bone Joint Surg Am. 2007;89:467–8.

    Article  Google Scholar 

  53. Hubert MG, Vadala G, Sowa G, Studer RK, Kang JD. Gene therapy for the treatment of degenerative disk disease. J Am Acad Orthop Surg. 2008;16:312–9.

    Article  PubMed  Google Scholar 

  54. Nishida K, Gilbertson LG, Robbins PD, Evans CH, Kang JD. Potential Applications of gene therapy to the treatment of intervertebral disc disorders. Clin Orthop Relat Res. 2000;379s:234–41.

    Article  Google Scholar 

  55. Shimer AL, Chadderdon RC, Gilbertson LG, Kang JD. Gene therapy approaches for intervertebral disc degeneration. Spine. 2004;23:2770–8.

    Article  Google Scholar 

  56. Meisel HJ, Siodla V, Ganey T, Minkus Y, Hutton WC, Alasevic OJ. Clinical experience in cell-based therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc. Biomol Eng. 2007;24:5–21.

    Article  CAS  PubMed  Google Scholar 

  57. Zhang Y, Phillips FM, Thonar EJ, Oegema T, An HS, Roman-Blas JA, He TC, Anderson DG. Cell therapy using articular chondrocytes overexpressing BMP-7 or BMP-10 in a rabbit disc organ culture model. Spine. 2008;33:831–8.

    Article  PubMed  Google Scholar 

  58. Hohaus C, Ganey TM, Minkus Y, Meisel HJ. Cell transplantation in lumbar spine disc degeneration disease. Eur Spine J. 2008;17:S492–503.

    Article  Google Scholar 

  59. Meisel HJ, Ganey T, Hutton WC, Libera J, Minkus Y, Alasevic O. Clinical experience in cell-based therapeutics: intervention and outcome. Eur Spine J. 2006;15:S397–405.

    Article  PubMed  Google Scholar 

  60. Alini M, Roughley PJ, Antoniou J, Stoll T, Aebi M. A biological approach to treating disc degeneration: not for today, but maybe for tomorrow. Eur Spine J. 2002;11:S215–20.

    PubMed  PubMed Central  Google Scholar 

  61. David Levi MD, Scott Horn DO, Sara Tyszko PA, Josh Levin MD, Charles Hecht-Leavitt MD, Edward Walko DO. Intradiscal platelet-rich plasma injection for chronic discogenic low back pain: preliminary results from a prospective trial. Pain Med. 2015;17:1010–22.

    PubMed  Google Scholar 

  62. Tuakli-Wosornu YA, Terry A, Boachie-Adjei K, Harrison JR, Gribbin CK, LaSalle EE, Nguyen JT, Solomon JL, Lutz GE. Lumbar intradiskal platelet-rich plasma (PRP) injections: a prospective, double-blind, randomized controlled study. PM R. 2016;8:1–10.

    Article  PubMed  Google Scholar 

  63. Hussein M, Hussein T. Effect of autologous platelet leukocyte rich plasma injections on atrophied lumbar multifidus muscle in low back pain patients with monosegmental degenerative disc disease. SICOT J. 2016;22:12.

    Article  Google Scholar 

  64. Wang Z, Perez-Terzic CM, Smith J, Mauck WD, Shelerud RA, Maus TP, Yang TH, Murad MH, Gou S, Terry MJ, Dauffenbach JP, Pingree MJ, Eldrige JS, Mohammed K, Benkhadra K, Van Wijnen AJ, Qu W. Efficacy of intervertebral disc regeneration with stem cells—a systematic review and meta-analysis of animal controlled trials. Gene. 2015;564:1–8.

    Article  CAS  PubMed  Google Scholar 

  65. Detiger SE, Helder MN, Smit TH, Hoogendoorn RJ. Adverse effects of stromal vascular fraction during regenerative treatment of the intervertebral disc: observations in a goat model. Eur Spine J. 2015;24:1992–2000.

    Article  PubMed  Google Scholar 

  66. Manchukonda R, Manchikanti KN, Cash KA, Pampati V, Manchikanti L. Facet joint pain in chronic spinal pain: an evaluation of prevalence and false-positive rate of diagnostic blocks. J Spinal Disord Tech. 2007;20:539–45.

    Article  PubMed  Google Scholar 

  67. Manchikanti L, Manchukonda R, Pampati V, Damron KS, McManus CD. Prevalence of facet joint pain in chronic low back pain in post surgical patients by controlled comparative local anesthetic blocks. Arch Phys Med Rehabil. 2007;88:449–55.

    Article  PubMed  Google Scholar 

  68. Jaumard NV, Welch WC, Winkelstein B. Spinal facet joint biomechanics and mechanotransduction in normal, injury and degenerative conditions. J Biomech Eng. 2011;133:1–33.

    Google Scholar 

  69. Bogduk N, Long DM. The anatomy of the so-called “articular nerves” and their relationship to facet denervation in the treatment of low-back pain. J Neurosurg. 1979;51:172–7.

    Article  CAS  PubMed  Google Scholar 

  70. Bogduk N. International Spinal Injection Society guidelines for the performance of spinal injection procedures. Part 1: Zygapophysial joint blocks. Clin J Pain. 1997;13:285–302.

    Article  CAS  PubMed  Google Scholar 

  71. Arzola C, Davies S, Rofael A. Ultrasound using the transverse approach to the lumbar spine provides reliable landmarks for labor epidurals. Anesth Analg. 2007;104:1188–92.

    Article  PubMed  Google Scholar 

  72. Helbig T, Lee CK. The lumbar facet syndrome. Spine. 1988;13:61–4.

    Article  CAS  PubMed  Google Scholar 

  73. Lippitt AB. The facet joint and its role in spine pain. Management with facet joint injections. Spine. 1984;9:746–50.

    Article  CAS  PubMed  Google Scholar 

  74. Schulte TL, Pietilä TA, Heidenreich J, Brock M, Stendel R. Injection therapy of lumbar facet syndrome: a prospective study. Acta Neurochir. 2006;148:1165–72.

    Article  CAS  PubMed  Google Scholar 

  75. Gofeld M. Ultrasound-guided zygapophysial nerve and joint injection. Tech Reg Anesth Pain Manag. 2009;3:150–3.

    Article  Google Scholar 

  76. Deyo RA. Treatment of lumbar spinal stenosis: a balancing act. Spine. 2010;10:625–7.

    Article  Google Scholar 

  77. Deyo RA, Gray DT, Kreuter W, Mirza S, Martin BI. United States trends in lumbar fusion surgery for degenerative conditions. Spine. 2005;30:1441–5.

    Article  PubMed  Google Scholar 

  78. Kalichman L, Cole R, Kim DH, Li L, Suri P, Guermazi A, Hunter DJ. Spinal stenosis prevalence and association with symptoms: the Framingham Study. Spine. 2009;9:545–50.

    Article  Google Scholar 

  79. Jenis LG, An HS. Spine update. Lumbar foraminal stenosis. Spine. 2000;25:389–94.

    Article  CAS  PubMed  Google Scholar 

  80. Markman JD, Gaud KG. Lumbar spinal stenosis in older adults: current understanding and future directions. Clin Geriatr Med. 2008;24:369–88.

    Article  PubMed  Google Scholar 

  81. Kreiner DS, Shaffer WO, Baisden J, Gilbert T, Summers J, Toton J, Reitman C. Diagnosis and treatment of degenerative lumbar spinal stenosis. Evidence-based clinical guidelines for multidisciplinary spine care. North American Spine Society; 2011.

    Google Scholar 

  82. Amundsen T, Weber H, Nordal HJ, Magnaes B, Abdelnoor M, Lilleas F. Lumbar spinal stenosis: conservative or surgical management? A prospective 10-year study. Spine. 2000;25:1424–35.

    Article  CAS  PubMed  Google Scholar 

  83. Chang Y, Singer DE, Wu YA, Keller RB, Atlas SJ. The effect of surgical and nonsurgical treatment on longitudinal outcomes of lumbar spinal stenosis over 10 years. J Am Geriatr Soc. 2005;53:785–92.

    Article  PubMed  Google Scholar 

  84. Zaina F, Tomkins-Lane C, Carragee E, Negrini S. Surgical versus non-surgical treatment for lumbar spinal stenosis. Cochrane Database Syst Rev. 2016.

    Google Scholar 

  85. Azimi P, Mohammadi HR, Benzel EC, Shahzadi S, Azhari S. Lumbar spinal canal stenosis classification criteria: a new tool. Asian Spine J. 2015;9:399–406.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Gordon SJ, Trott P, Grimmer KA. Waking cervical pain and stiffness, headache, scapular or arm pain: gender and age effects. Aust J Physiother. 2002;48:9–15.

    Article  PubMed  Google Scholar 

  87. Green GS. Living with hipermobility. Rheumatology. 2001;40:487–9. Paper read at XIV Eular COngress, Glasgow 10 June 1999.

    Google Scholar 

  88. Kibler WB, McMullen J. Scapular dyskinesis and its relation to shoulder pain. J Am Acad Orthop Surg. 2003;11:142–51.

    Article  PubMed  Google Scholar 

  89. Young EE, Lariviere WR, Belfer I. Genetic basis of pain variability: recent advances. J Med Genet. 2012;49:1–9.

    Article  PubMed  Google Scholar 

  90. Manchikanti L, Singh V, Pampati V, Damron KS, Barnhill RC, Beyer C, Cash KA. Evaluation of the relative contributions of various structures in chronic low back pain. Pain Physician. 2001;4(4):308–16.

    CAS  PubMed  Google Scholar 

  91. Radhakrishnan K, Litchy WJ, O’Fallon WM, Kurland LT. Epidemiology of cervical radiculopathy. A population-based study from Rochester, Minnesota, 1976 through 1990. Brain. 1994;117:325–35.

    Article  PubMed  Google Scholar 

  92. Tanaka Y, Kokubun S, Sato T, Ozawz H. Cervical roots as origin of pain in the neck or scapular regions. Spine. 2006;31:E568–73.

    Article  PubMed  Google Scholar 

  93. Murphey F, Simmons JCH, Brunson B. Surgical treatment of laterally ruptured cervical disc. Review of 648 cases, 1939 to 1972. J Neurosurg. 1973;38:679–83.

    Article  CAS  PubMed  Google Scholar 

  94. Mizutamari M, Sei A, Tokiyoshi A, Fujimoto T, Taniwaki T, Togami W, Mizuta H. Corresponding scapular pain with the nerve root involved in cervical radiculopathy. J Orthop Surg. 2010;18:356–60.

    Article  Google Scholar 

  95. Brioschi ML, Teixeira MJ, Silva FMRM, Colman D. Medical thermography textbook: principles and applications. 1º Edição. Sao Paulo: Ed. Andreoli; 2010.

    Google Scholar 

  96. Farrell KP. Implementation of a treatment based classification system for neck pain: a pilot study. Orthop Phys Ther Pract. 2011;23:91–9.

    Google Scholar 

  97. Wang WT. Effectiveness of physical therapy for patients with neck pain: an individualized approach using a clinical decision-making algorithm. Am J Phys Med Rehabil. 2003;82:203–18.

    PubMed  Google Scholar 

  98. Chen CY, Hu CC, Weng PW, Huang YM, Chiang CJ, Chen CH, Tsuang YH, Yang RS, Sun JS, Cheng CK. Extracorporeal shockwave therapy improves short-term functional outcomes of shoulder adhesive capsulitis. J Shoulder Elb Surg. 2014;23:1843–51.

    Article  Google Scholar 

  99. Gleitz M. Shockwave therapy in practice: myofascial syndrome and trigger points, level 10 book. 1st ed. Heibron: Publishing House Daniela Bamberg; 2011. p. 208.

    Google Scholar 

  100. Ramon S, Gleitz M, Hernandez L, Romero LD. Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia. Int J Surg. 2015;24:201–6.

    Article  PubMed  Google Scholar 

  101. Romeo P, Lavanga V, Pagani D, Sansone D. Extracorporeal shock wave therapy in musculoskeletal disorders: a review. Med Princ Pract. 2014;23:7–13.

    Article  PubMed  Google Scholar 

  102. Moya D, Ramón S, Guiloff L, Gerdesmeyer L. Current knowledge on evidence-based shockwave treatmentsfor shoulder pathology. Int J Surg. 2015;24(part B):171–8.

    Article  PubMed  Google Scholar 

  103. Feinberg SD. Assessing disability in the pain patient. Comprehensive treatment of chronic pain by medical, interventional, and behavioral approaches. New York: Springer; 2011. p. 1031–104.

    Google Scholar 

  104. Aufiero D, Vincent H, Sampson S, Bodor M. Regenerative injection treatment in the spine: review and case series with platelet rich plasma. J Stem Cells Res Rev Rep. 2015;2:1–9.

    Google Scholar 

  105. Obata S, Akeda K, Imanishi T, Masuda K, Bae W. Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study. Arthritis Res Ther. 2012;14:1–11.

    Article  CAS  Google Scholar 

  106. Kim HJ, Yeom JS, Koh YG, Yeo JE, Kang KT, Kang YM, Chang BS, Lee CK. Anti-inflammatory effect of platelet-rich plasma on nucleus pulposus cells with response of TNF-α and IL-1. J Orthop Res. 2014;32:551–6.

    Article  CAS  PubMed  Google Scholar 

  107. Akeda K, Imanishi T, Ohishi K, Masuda K, Uchida A, Sakakibara T, Kasai Y, Sudo A. Intradiscal injection of autologous serum isolated from platelet rich plasma for the treatment of discogenic low back pain: preliminary prospective clinical trial GP141. Spine. 2011.

    Google Scholar 

  108. Mora MV, MAR I, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. J Stem Cells. 2015;7:691–9.

    Article  Google Scholar 

  109. Murrell WD, Anz AW, Badsha H, Bennett WF, Boykin RE, Caplan AI. Regenerative treatments to enhance orthopedic surgical outcome. PM R. 2015;7:S41–52.

    Article  PubMed  Google Scholar 

  110. Jo CH, Kim JE, Yoon KS, Lee JH, Kang SB, Lee JH, Han HS, Rhee SG, Shin S. Does platelet-rich plasma accelerate recovery after rotator cuff repair? A prospective cohort study. Am J Sports Med. 2011;39:2082–90.

    Article  PubMed  Google Scholar 

  111. Osti L, Buda M, Buono AD, Osti R, Massari L. Clinical evidence in the treatment of rotator cuff tears with hyaluronic acid. Muscles Ligaments Tendons J. 2016;5(4):270–5.

    PubMed  PubMed Central  Google Scholar 

  112. Brecht M. Increased hyaluronate synthesis is required for fibroblast detachment and mitosis. Biochem J. 1986;239:445–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen. 1999;7:79–89.

    Article  CAS  PubMed  Google Scholar 

  114. Itokazu M, Matsunaga T. Clinical evaluation of high-molecular-weight sodium hyaluronate for the treatment of patients with periarthritis of the shoulder. Clin Ther. 1995;17:946–55.

    Article  CAS  PubMed  Google Scholar 

  115. Saito S, Furuya T, Kotake S. Therapeutic effects of hyaluronate injections in patients with chronic painful shoulder: a meta-analysis of randomized controlled trials. Arthritis Care Res. 2010;62:1009–18.

    Article  CAS  Google Scholar 

  116. Shibata Y, Midorikawa K, Emoto G, Naito M. Clinical evaluation of sodium hyaluronate for the treatment of patients with rotator cuff tear. J Shoulder Elb Surg. 2001;10:209–16.

    Article  CAS  Google Scholar 

  117. Stern M, Longaker MT, Stern R. Hyaluronic acid and its modulation in fetal and adult wound healing. In: Adzick NS, Longaker MT, editors. Fetal wound healing. New York: Elsevier; 1991. p. 189–98.

    Google Scholar 

  118. Weil AJ. High molecular weight hyaluronan for treatment of chronic shoulder pain associated with glenohumeral arthritis. Med Devices (Auckl). 2011;4:99–105.

    Article  CAS  Google Scholar 

  119. McCrory P, Bell S. Nerve entrapment syndromes as a cause of pain in the hip, groin and buttock. Sports Med. 1999;27:261–74.

    Article  CAS  PubMed  Google Scholar 

  120. Maigne JY, Dourseunian L. Entrapment neuropathy of medial superior cluneal nerve, nineteen cases surgically treated, with a minimum of 2 years follow-up. Spine. 1997;10:1156–9.

    Article  Google Scholar 

  121. Harmon D, Alexiev V. Sonoanatomy and injection technique of the iliolumbar ligament. Pain Physician. 2011;14:469–74.

    PubMed  Google Scholar 

  122. Davenport KL, Campos JS, Nguyen J, Saboeiro G, Adler RS, Moley PJ. Ultrasound-guided intratendinous injections with platelet-rich plasma or autologous whole blood for treatment of proximal hamstring tendinopathy a double-blind randomized controlled trial. J Ultrasound Med. 2015;34:1455–63.

    Article  PubMed  Google Scholar 

  123. Jacobson JA, Yablon CM, Henning PT, Kazmers IS, Urquhart A, Hallstrom B, Parameswaran A. Greater trochanteric pain syndrome percutaneous tendon fenestration versus platelet-rich plasma injection for treatment of gluteal tendinosis. J Ultrasound Med. 2016;35:2413–20.

    Article  PubMed  Google Scholar 

  124. Ganz R, Parvizi J, Beck M, Leunig M, Nötzli H, Siebenrock K. Femoroacetabular impingement: a cause for osteoarthritis of the hip. Clin Orthop Relat Res. 2003;417:112–20.

    Google Scholar 

  125. Clohisy JC, Knaus ER, Hunt DM, Lesher JM, Harris-Hayes M, Prather H. Clinical presentation of patients with symptomatic anterior hip impingement. Clin Orthop Relat Res. 2009;467:638–44.

    Article  PubMed  PubMed Central  Google Scholar 

  126. Migliore A, Granata M, Tormenta S, Laganà B, Piscitelli P, Bizzi E, Iannessi F. Hip viscosupplementation under ultra-sound guidance riduces NSAID consumption in symptomatic hip osteoarthritis patients in a long follow-up. Data from Italian registry. Eur Rev Med Pharmacol Sci. 2011;15:25–34.

    CAS  PubMed  Google Scholar 

  127. Chahla J, LaPrade RF, Mardones R, Huard J, Philippon MJ, Nho S, Pascual-Garrido C. Biological therapies for cartilage lesions in the hip: a new horizon. Orthopedics. 2016;39:715–23.

    Article  Google Scholar 

  128. Rafols C, Monckeberg JE, Numair J, Botello J, Rosales J. Platelet-rich plasma augmentation of arthroscopic hip surgery for femoroacetabular impingement: a prospective study with 24-month follow-up. Arthroscopy. 2015;31:1886–92.

    Article  PubMed  Google Scholar 

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Correspondence to José Fábio Santos Duarte Lana .

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Lana, J.F.S.D. et al. (2017). The Role of Biological Treatments in Spine Disorders. In: Gobbi, A., Espregueira-Mendes, J., Lane, J., Karahan, M. (eds) Bio-orthopaedics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54181-4_48

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