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Hirnstrukturelle und funktionelle Bildgebung

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Altersdepression

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Zusammenfassung

Im Rahmen der Altersdepression diente die strukturelle und funktionelle Bildgebung bisher primär der Erforschung der neurobiologischen Korrelate der Erkrankung und lieferte wichtige Erkenntnisse zum besseren Verständnis der zugrundeliegenden pathophysiologischen Mechanismen. Neuere Studien verdeutlichen darüber hinaus einen potenziellen Nutzen zur Prädiktion des Erfolgs einer Pharmako- und Psychotherapie und damit zur Auswahl der passenden therapeutischen Intervention. In der klinischen Praxis findet die Bildgebung im Rahmen der Differenzial- und Ausschlussdiagnostik neurodegenerativer und anderer hirnpathologischer Erkrankungen sowie im Rahmen der Sicherheitsdiagnostik für den Einsatz nichtpharmakologischer somatischer Interventionen Anwendung. Das vorliegende Kapitel stellt den Stand der klinischen Grundlagenforschung der strukturellen und funktionellen Bildgebung bei Altersdepression dar. Darüber hinaus wird der aktuelle Nutzen der Bildgebung in der klinischen Praxis bei Altersdespression beschrieben.

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Literatur

  • Agudelo C, Aizenstein HJ, Karp JF, Reynolds III CF (2015) Applications of magnetic resonance imaging for treatment-resistant late-life depression. Dialogues Clin Neurosci 17(2):151–169

    PubMed  PubMed Central  Google Scholar 

  • Aizenstein HJ, Butters MA, Wu M, Mazurkewicz LM, Stenger VA, Gianaros PJ, Becker JT, Reynolds CF, Carter CS (2009) Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena. Am J Geriat Psychiatry 17(1):30–42

    Article  Google Scholar 

  • Alexopoulos GS, Kiosses DN, Choi SJ, Murphy CF, Lim KO (2002) Frontal white matter microstructure and treatment response of late-life depression: a preliminary study. Am J Psychiatry 159(11):1929–1932

    Article  PubMed  Google Scholar 

  • Alexopoulos GS, Murphy CF, Gunning-Dixon FM, Latoussakis V, Kanellopoulos D, Klimstra S, Lim KO, Hoptman MJ (2008) Microstructural white matter abnormalities and remission of geriatric depression. Am J Psychiatry 165(2):238–244

    Article  PubMed  Google Scholar 

  • Alexopoulos GS, Hoptman MJ, Kanellopoulos D, Murphy CF, Lim KO, Gunning FM (2012) Functional connectivity in the cognitive control network and the default mode network in late-life depression. J Affect Disord 139(1):56–65

    Article  PubMed  PubMed Central  Google Scholar 

  • Alves GS, Karakaya T, Fußer F, Kordulla M, O'Dwyer L, Christl J, Magerkurth J, Oertel-Knöchel V, Knöchel C, Prvulovic D (2012) Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression. Psychiat Res Neuroim 203(2):194–200

    Article  Google Scholar 

  • Andreescu C, Butters MA, Begley A, Rajji T, Wu M, Meltzer CC, Reynolds CF, Aizenstein H (2008) Gray matter changes in late life depression – a structural MRI analysis. Neuropsychopharmacology 33(11):2566–2572

    Article  PubMed  Google Scholar 

  • Ballmaier M, Narr KL, Toga AW, Elderkin-Thompson V, Thompson PM, Hamilton L, Haroon E, Pham D, Heinz A, Kumar A (2008) Hippocampal morphology and distinguishing late-onset from early-onset elderly depression. Am J Psychiatry 165(2):229–237

    Article  PubMed  Google Scholar 

  • Bella R, Pennisi G, Cantone M, Palermo F, Pennisi M, Lanza G, Zappia M, Paolucci S (2010) Clinical presentation and outcome of geriatric depression in subcortical ischemic vascular disease. Gerontology 56(3):298–302

    Article  CAS  PubMed  Google Scholar 

  • Burke J, McQuoid DR, Payne ME, Steffens DC, Krishnan RR, Taylor WD (2011) Amygdala volume in late-life depression: relationship with age of onset. Am J Geriatr Psychiatry 19(9):771–776

    Article  PubMed  PubMed Central  Google Scholar 

  • Dalby R, Chakravarty M, Ahdidan J, Sørensen L, Frandsen J, Jonsdottir K, Tehrani E, Rosenberg R, Østergaard L, Videbech P (2010a) Localization of white-matter lesions and effect of vascular risk factors in late-onset major depression. Psychol Med 40(08):1389–1399

    Article  CAS  PubMed  Google Scholar 

  • Dalby RB, Frandsen J, Chakravarty MM, Ahdidan J, Sørensen L, Rosenberg R, Videbech P, Østergaard L (2010b) Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression. Psychiat Res Neuroim 184(1):38–48

    Article  Google Scholar 

  • DGPPN, BÄK, KBV, AWMF, AkdÄ, BPtK, BApK, DAGSHG, DEGAM, DGPM, DGPs, DGRW (Hrsg) für die Leitliniengruppe Unipolare Depression* (2015) S3-Leitlinie/Nationale VersorgungsLeitlinie Unipolare Depression – Langfassung, 2. Aufl, Vers 2, Nov 2015. (*Organisationen, die in der Leitliniengruppe kooperierten: DGPPN, BÄK, KBV, AWMF, ACKPA, AkdÄ, BPtK, BApK, DAGSHG, DEGAM, DGPM, DGPs, DGRW, BDK, BDP, BPM, BVDN, BVDP, BVVP, CPKA, DÄVT, DFT, DGGPP, DGPT, DGVT, DPG, DPV, DPtV, DVT, GwG, Stiftung Deutsche Depressionshilfe). doi:10.6101/AZQ/000266. http//:www.depression.versorgungsleitlinien.de. Zugegriffen: 14. Feb 2017

  • Disabato BM, Morris C, Hranilovich J, D'Angelo GM, Zhou G, Wu N, Doraiswamy PM, Sheline YI. (2014) Comparison of brain structural variables, neuropsychological factors, and treatment outcome in early-onset versus late-onset late-life depression. Am J Geriatr Psychiatry 22(10):1039–1046

    Article  PubMed  Google Scholar 

  • Du M, Liu J, Chen Z, Li J, Kuang W, Yang Y, Zhang W, Zhou D, Bi F (2014) Brain grey matter volume alterations in late-life depression. J Psychiatry Neurosci 39(6):397

    Article  PubMed  PubMed Central  Google Scholar 

  • Gunning-Dixon FM, Walton M, Cheng J, Acuna J, Klimstra S, Zimmerman ME, Brickman AM, Hoptman MJ, Young RC, Alexopoulos GS (2010) MRI signal hyperintensities and treatment remission of geriatric depression. J Affect Disord 126(3):395–401

    Article  PubMed  PubMed Central  Google Scholar 

  • Gunning FM, Cheng J, Murphy CF, Kanellopoulos D, Acuna J, Hoptman MJ, Klimstra S, Morimoto S, Weinberg J, Alexopoulos GS (2009) Anterior cingulate cortical volumes and treatment remission of geriatric depression. Int J Geriatric Psychiatry 24(8):829–836

    Article  Google Scholar 

  • Herrmann LL, Le Masurier M, Ebmeier KP (2008) White matter hyperintensities in late life depression: a systematic review. J Neurol Neurosurg Psychiatry 79(6):619–624

    Article  CAS  PubMed  Google Scholar 

  • Hsieh MH, McQuoid DR, Levy RM, Payne ME, MacFall JR, Steffens DC (2002) Hippocampal volume and antidepressant response in geriatric depression. J Geriatr Psychiatry 17(6):519–525

    Article  Google Scholar 

  • Lesser IM, Boone KB, Mehringer CM, Wohl MA (1996) Cognition and white matter hyperintensities in older depressed patients. Am J Psychiatry 153(10):1280

    Article  CAS  PubMed  Google Scholar 

  • Mackin RS, Tosun D, Mueller SG, Lee J-Y, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW (2013) Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response. Am J Geriatr Psychiatry 21(8):794–802

    Article  PubMed  Google Scholar 

  • Murata T, Kimura H, Omori M, Kado H, Kosaka H, Iidaka T, Itoh H, Wada Y (2001) MRI white matter hyperintensities, 1H‐MR spectroscopy and cognitive function in geriatric depression: a comparison of early‐and late‐onset cases. Int J Geriatr Psychiatry 16(12):1129–1135

    Article  CAS  PubMed  Google Scholar 

  • Sexton C, McDermott L, Kalu U, Herrmann L, Bradley K, Allan C, Le Masurier M, Mackay C, Ebmeier K (2012a) Exploring the pattern and neural correlates of neuropsychological impairment in late-life depression. Psychol Med 42(06):1195–1202

    Article  CAS  PubMed  Google Scholar 

  • Sexton CE, Allan CL, Le Masurier M, McDermott LM, Kalu UG, Herrmann LL, Mäurer M, Bradley KM, Mackay CE, Ebmeier KP (2012b) Magnetic resonance imaging in late-life depression: multimodal examination of network disruption. Arch Gen Psychiatry 69(7):680–689

    Article  PubMed  Google Scholar 

  • Sheline YI, Price JL, S Neil Vaishnavi B, Mintun MA, Barch DM, Epstein AA, Wilkins CH, Snyder AZ, Couture L, Schechtman K (2008) Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors. Am J Psychiatry 165(4):524–532

    Article  PubMed  PubMed Central  Google Scholar 

  • Shimony JS, Sheline YI, D'Angelo G, Epstein AA, Benzinger TL, Mintun MA, McKinstry RC, Snyder AZ (2009) Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor imaging study. Biol Psychiatry 66(3):245–252

    Article  PubMed  PubMed Central  Google Scholar 

  • Smith GS, Kramer E, Ma Y, Kingsley P, Dhawan V, Chaly T, Eidelberg D (2009) The functional neuroanatomy of geriatric depression. Int J Geriatr Psychiatry 24(8):798–808

    Article  PubMed  PubMed Central  Google Scholar 

  • Sneed JR, Culang-Reinlieb ME, Brickman AM, Gunning-Dixon FM, Johnert L, Garcon E, Roose SP (2011) MRI signal hyperintensities and failure to remit following antidepressant treatment. J Affect Disord 135(1):315–320

    Article  CAS  PubMed  Google Scholar 

  • Tadayonnejad R, Ajilore O (2014) Brain network dysfunction in late-life depression. A literature review. J Geriatr Psychiatry Neurol 27(1):5–12

    Article  PubMed  Google Scholar 

  • Taylor WD, Kuchibhatla M, Payne ME, MacFall JR, Sheline YI, Krishnan KR, Doraiswamy PM (2008) Frontal white matter anisotropy and antidepressant remission in late-life depression. PloS one 3(9):e3267

    Article  PubMed  PubMed Central  Google Scholar 

  • Taylor WD, MacFall JR, Boyd B, Payne ME, Sheline YI, Krishnan RR, Doraiswamy PM (2011) One-year change in anterior cingulate cortex white matter microstructure: relationship with late-life depression outcomes. Am J Geriatr Psychiatry 19(1):43–52

    Article  PubMed  PubMed Central  Google Scholar 

  • Taylor WD, Aizenstein HJ, Alexopoulos GS (2013) The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry 18(9):963–974

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Taylor WD, McQuoid DR, Payne ME, Zannas AS, MacFall JR, Steffens DC (2014) Hippocampus atrophy and the longitudinal course of late-life depression. Am J Geriatr Psychiatry 22(12):1504–1512

    Article  PubMed  Google Scholar 

  • Wang L, K Ranga Krishnan M, Steffens DC, Potter GG, Dolcos F, McCarthy G (2008) Depressive state-and disease-related alterations in neural responses to affective and executive challenges in geriatric depression. Am J Psychiatry 165(7):863–871

    Article  PubMed  Google Scholar 

  • Wen MC, Steffens DC, Chen MK, Zainal NH (2014) Diffusion tensor imaging studies in late‐life depression: systematic review and meta‐analysis. Int J Geriatr Psychiatry 29(12):1173–1184

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Universitätsmedizin Mainz, Klinik für Psychiatrie und Psychotherapie, Untere Zahlbacher Straße 8, 55131, Mainz, Deutschland

    Dominik Wolf

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  1. Dominik Wolf
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Correspondence to Dominik Wolf .

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Editors and Affiliations

  1. Abteilung für Gerontopsychiatrie Rheinhessen-Fachklinik Landeskrankenhaus (AöR), Alzey, Germany

    Andreas Fellgiebel

  2. Fachbereich Psychologie, Eberhard-Karls-Universität Tübingen, Tübingen, Germany

    Martin Hautzinger

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Wolf, D. (2017). Hirnstrukturelle und funktionelle Bildgebung. In: Fellgiebel, A., Hautzinger, M. (eds) Altersdepression. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53697-1_6

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  • DOI: https://doi.org/10.1007/978-3-662-53697-1_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-53696-4

  • Online ISBN: 978-3-662-53697-1

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