Abstract
Quantitative differences in the expression of HLA antigens have been shown to influence T-cell mediated immune responses. On murine lymphocytes and thymocytes (1), as well as on human cell lines (2), differential expression of MHC class I antigens has been described. For further insight into regulation of HLA class I antigen expression, DNA-mediated gene transfer has been applied. L(tk−) cells transfected with the genes coding for the heavy chain of the HLA-A2 and -B7 antigen revealed a two to three times more increased expression of the HLA-B compared to the HLA-A locus molecule after stimulation with mouse interferon (3).
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References
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Schmidt H, Forsthuber T, Bühring H-J, Müller CA. Differential expression of the HLA-B7 and the HLA-A2 gene in transfected mouse L(tk−) cells after stimulation by mouse interferon. Immunobiol 1987; 174: 51.
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© 1989 Springer Science+Business Media New York
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Schmidt, H. et al. (1989). Differential Regulation of HLA B Antigen Expression by Interferon. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_41
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DOI: https://doi.org/10.1007/978-3-662-39946-0_41
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-38980-5
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