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Ceramide, Aging and Cellular Senescence

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Sphingolipid-Mediated Signal Transduction

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Cellular senescence is defined as the finite life span of mammalian cells in culture and has been investigated for the last thirty years. Research employing mammalian cells as well as cells from lower organisms such as C. elegans and yeast has established several models to explain the altered cellular functions in senescence. One model proposes that cellular senescence is associated with accumulated DNA damage and reduced DNA repair function. The other model argues that alterations of genetic control programs could lead to cellular senescence. There is evidence to support both hypotheses, yet the underlying mechanisms of cellular senescence are still not clear.

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  1. Joanna Y. Lee
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  2. Lina M. Obeid
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Lee, J.Y., Obeid, L.M. (1997). Ceramide, Aging and Cellular Senescence. In: Sphingolipid-Mediated Signal Transduction. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22425-0_5

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  • DOI: https://doi.org/10.1007/978-3-662-22425-0_5

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