Abstract
Despite a burgeoning number of recent investigations and increasingly rigorous scrutiny, a universally acceptable definition of normal biological aging is still not available. The origins of senescence remain enigmatic, and little agreement exists regarding its true nature. While most would accept as genuine aging phenomena the diverse processes of hair graying, wrinkling of skin, and arteriosclerosis, they would, on the other hand, reserve embryogenesis, somatic growth, and pubescence for development. Both kinds of phenomena are clearly time-dependent, but the interface between them is often blurred (Goldstein, S., 1971a). The conceptual difficulty is exemplified by the frequent juxtaposition of involution and new development, even at early and middle stages of the life span (Saunders and Fallon, 1966). Cogent examples are the placenta vs. the fetus during gestation and the replacement of deciduous teeth by permanent dentition during infancy. During childhood, atrophy of the thymus occurs when virtually all other organs are growing and maturing, while the menopausal ovary involutes relatively abruptly in comparison with other organs in the middle-aged female. One could invoke examples of involution at the molecular level such as the loss during fetal life of various proteins including ϒ-hemoglobin, carcinoembryonic antigen, α-fetoprotein, and others (Gold, 1971). In short, attempts to delineate the point at which development is succeeded by aging may be futile, since both processes probably operate along the same continuum.
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Alberti, K. G., Young, J. D., and Hockaday, T. O., 1974, Werner’s syndrome: Metabolic observations, Proc. R. Soc. Med. 67:36–38.
Alton, D. J., McDonald, P., and Reilly, B. J., 1972, Cockayne’s syndrome: A report of three cases, Radiology 102:403–406.
Ammann, A. J., Cain, W. A., Ishizaka, K., Hong, R., and Good, R. A., 1969, Immunoglobulin E deficiency in ataxia-telangiectasia, N. Engl. J. Med. 281:469–472.
Andres, W., Pozefsky, T., Swerdloff, R. S., and Tobin, J. D., 1975, Effect of aging on carbohydrate metabolism, Adv. Metab. Disord. Suppl. 1:349–355.
Atkins, L., 1954, Progeria: Report of a case with post-mortem findings, N. Engl. J. Med. 250:1065–1069.
Bach, F. H., and van Rood, J. J., 1976, The major histocompatibility complex: Genetics and biology, N. Engl. J. Med. 295: 806–813, 872-878, 927-936.
Balci, S., Say, B., and Kinik, E., 1970, Werner’s syndrome, Turk. J. Pediatr. 12:89–97.
Benditt, E. P., and Benditt, J. M., 1973, Evidence for a monoclonal origin of human atherosclerotic plaques, Proc. Natl. Acad. Sci. U.S.A. 70:1753–1756.
Bhakoo, O. N., Garg, S. K., and Sehgal, V. N., 1965, Progeria with unusual ocular manifestations: Report of a case with a review of the literature, Indian Pediatr. 2:164–169.
Bingham, H. G., and Anderson, P. G., 1970, Coverage of cutaneous ulcers in Werner’s syndrome, Acta Derm.-Venereol. 50:237–239.
Blinstrub, R. W., Lehman, R., and Steinberg, T. H., 1964, Poikiloderma congenitale: Report of two cases, Arch. Dermatol. 89:659–664.
Blizzard, R. M., 1965, Dwarfism, in: Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence (L. Wilkins, ed.), pp. 160–194, Charles C. Thomas, Springfield, Illinois.
Block, B., and Stauffer, H., 1929, Skin diseases of endocrine system (dyshormonal dermatoses): Poikiloderma-like changes in connection with underdevelopment of the sexual glands and dystrophia adiposogenitalis, Arch. Dermatol. Syphilol. 19:22–34.
Boder, E., and Sedgwick, R. P., 1958, Ataxia-telangiectasia: A familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection, Pediatrics 21:526–554.
Bottomley, W. K., and Box, J. M., 1976, Dental anomalies in the Rothmund-Thomson syndrome: Report of a case, Oral Surg. 4:321–326.
Boué, A., Boué, J., Cure, S., Deluchat, C., and Perraudin, N., 1975, In vitro cultivation of cells from aneuploid human embryos: Initiation of cell lines and longevity of the culture, In Vitro 11:409–413.
Boyd, M. W. J., and Grant, A. P., 1959, Werner’s syndrome (progeria of the adult): Further pathological and biochemical observations, Br. Med. J. 2:920–925.
Bradley, M. O., Erickson, L. C., and Kohn, K. W., 1976, Normal DNA strand rejoining and absence of DNA crosslinking in progeroid and aging human cells, Mutat. Res. 37:279–292.
Brautbar, C., Pellegrino, M. A., Ferrone, S., Reisfeld, R. A., Payne, R., and Hayflick, L., 1973, Fate of HL-A antigens in aging cultured human diploid cell strains. II. Quantitative absorption studies, Exp. Cell Res. 78:367–375.
Bristow, J. H., 1973, Werner’s syndrome: Clinical features and cataract surgery, S. Afr. Med. J. 47:566–569.
Brodrick, J. D., and Dark, A. J., 1973, Corneal dystrophy in Cockayne’s syndrome, Br. J. Opthalmol. 57:391–399.
Bullock, J. D., and Howard, R.O., 1973, Werner’s syndrome, Arch. Ophthalmol. 90:53–56.
Burch, P. R. J., and Milunsky, A., 1969, Early-onset diabetes mellitus in general and Down’s syndrome populations: Genetics, etiology, and pathogenesis, Lancet 1:554–558.
Burnet, F. M., 1974, Intrinsic Mutagenesis: A Genetic Approach to Aging, John Wiley & Sons, New York.
Burnett, J. W., 1968, Werner’s syndrome, South. Med. J. 61:207–209.
Cahill, G. F., 1975, Disorders of carbohydrate metabolism, in: Textbook of Medicine (P. B. Beeson and W. McDermott, eds.), pp. 1599-1619, W. B. Saunders Co., Philadelphia. Cahill, G. F., Etzwiler, D. D., and Freinkel, N., 1976, “Control” and diabetes, N. Engl. J. Med. 294:1004–1005.
Carr, D. H., 1975, Cytogenetics and the pathologist, Pathobiol. Annu. 10:93–144.
Chaganti, R. S. K., Schonberg, S., and German, J., 1974, A manyfold increase in sister chromatid exchanges in Bloom’s syndrome lymphocytes, Proc. Natl. Acad. Sci. U.S.A. 71:4508–4512.
Childs, B., and Der Kaloustian, V. M., 1968, Genetic heterogeneity, N. Engl. J. Med. 279: 1205–1212, 1267-1279.
Cleaver, J. E., 1970, DNA damage and repair in light-sensitive human skin disease, J. Invest. Dermatol. 54:181–195.
Cleaver, J. E., and Bootsma, D., 1975, Xeroderma pigmentosum: Biochemical and genetic characteristics, Annu. Rev. Genet. 9:19–38.
Cleaver, J. E., Bootsma, D., and Friedberg, E., 1975, Human diseases with genetically altered DNA repair processes, Genetics 79:215–225.
Cockayne, E. A., 1936, Dwarfism with retinal atrophy and deafness, Arch. Dis. Child. 11:1–8.
Cohen, M. M., Shaham, M., Dagan, J., Shmueli, E., and Kohn, G., 1975, Cytogenetic investigations in families with ataxia-telangiectasia, Cytogenet. Cell Genet. 15:338–356.
Cole, H. N., Giffen, H. K., Simmons, J. T., and Stroud, G. M., III, 1945, Congenital cataracts in sisters with congential ectoderma dysplasia, J. Am. Med. Assoc. 129:723–728.
Coles, W. H., 1969, Ocular manifestations of Cockayne’s syndrome, Am. J. Ophthalmol. 67:762–764.
Comfort, A., 1964, Ageing: The Biology of Senescence, Holt, Rinehart & Winston, New York.
Comfort, A., 1969, Test-battery to measure ageing-rate in man, Lancet 2:1411–1415.
Cotton, R. B., Keats, T. E., and McCoy, E. E., 1970, Abnormal blood glucose regulation in Cockayne’s syndrome, Pediatrics 46:54–60.
Cox, R. P., 1974, Cell Communication, John Wiley & Sons, New York.
Crapper, D. R., Dalton, A. J., Skopitz, M., Scott, J. W., and Hachinski, V. C., 1975, Alzheimer degeneration in Down syndrome: Electrophysiologic alterations and histopathologic findings, Arch. Neurol. 33:618–623.
Creutzfeldt, W., Kobberling, J., and Neel, J. V. (eds.), 1975, The Genetics of Diabetes Mellitus, Springer-Verlag, New York.
Cristofalo, V. J., 1972, Animal cell cultures as a model system for the study of aging, Adv. Gerontol. Res. 4:45–79.
Crome, L., and Kanjilal, G. C., 1971, Cockayne’s syndrome: Case report, J. Neurol. Neurosurg. Psychiatry 34:171–178.
Cunliffe, P. N., Mann, J. R., Cameron, A. H., Roberts, K. D., and Ward, H. W. C., 1975, Radio sensitivity in ataxia telangiectasia, Br. J. Radiol. 48:374–376.
Dalton, A. J., Crapper, D. R., and Schlotterer, G. R., 1974, Alzheimer’s disease in Down’s syndrome: Visual retention deficits, Cortex 10:366–377.
Danes, B. S., 1971, Progeria: A cell culture study on aging, J. Clin. Invest. 50:2000–2003.
DeBusk, F. L., 1972, The Hutchinson-Gilford progeria syndrome: Report of four cases and review of the literature, J. Pediatr. 80(Part 2):695–724.
Degreef, H., 1971, The Werner syndrome, Dermatologica 142:45–49.
Diem, E., 1975, The Rothmund-Thomson syndrome: A case report, Hautarzt 26:425–429.
Down, J. L. H., 1866, Observations on ethnic classification of idiots, Clin. Lect. Rep. London Hosp. 3:259–262.
Driban, N. E., and Bertranou, E. G., 1975, Adult progeria (Werner’s syndrome), Med. Cutanea 3:213–222.
Elmore, E., and Swift, M., 1976a, Growth of cultured cells from patients with Fanconi’s anemia, J. Cell. Physiol. 87: 229–234.
Elmore, E., and Swift, M., 1976b, Growth of cultured cells from patients with ataxiatelangiectasia, J. Cell. Physiol. 89: 429–432.
Engle, E., and Forbes, A. P. 1965, Cytogenetic and clinical findings in 48 patients with congenitally defective or absent ovaries, Medicine (Baltimore) 44:135–164.
Epstein, C. J., Martin, G. M., Schultz, A. L., and Motulsky, A. G., 1966, Werner’s syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process, Medicine (Baltimore) 45:177–221.
Epstein, J., Williams, J. R., and Little, J. B., 1973, Deficient DNA repair in human progeroid cells, Proc. Natl. Acad. Sci. U.S.A. 70:977–981.
Epstein, J., Williams, J. R., and Little, J. B., 1974, Rate of DNA repair in progeric and normal human fibroblasts, Biochem. Biophys. Res. Commun. 59:850–856.
Fajans, S. S., Floyd, J. C., Tattersall, R. B., Williamson, J. R., Pek, S., and Taylor C. I., 1976, The various faces of diabetes in the young, Arch. Intern. Med. 136:194–202.
Faye, I., Ruscher, H., Marchand, J. P., Bloc, G., and Toure, M. F., 1973, A case of Werner’s syndrome, Bull. Soc. Med. Afr. Noire Lang. Fr. 18:564–566.
Feigin, R. D., Vietti, T. J., Wyatt, R. G., Kaufman, D. G., and Smith, C. H., 1970, Ataxia telangiectasia with granulocytopenia, J. Pediatr. 77:431–438.
Feingold, M., and Kidd, R., 1971, Progeria and scleroderma in infancy, Am. J. Dis. Child. 122:61–62.
Felig, P., Wahren, J., Sherwin, R., and Hendler, R., 1976, Insulin, glucagon, and somatostatin in normal physiology and diabetes mellitus, Diabetes 25:1091–1099.
Ferrari-Sacco, A., Carolei, P., Emanuele, B., Marasso, A., and Marengo, G., 1972, Etiopathogenetic, clinical and anatomo-histological notes on a very rare form of congenital anomaly (Werner’s syndrome or Rothmund-Thomson syndrome) associated with pulmonary tuberculosis, Minerva Med. 63:2563–2573.
Finkelberg, R., 1976, Studies on cells from patients with Fanconi’s anemia, Ph.D. thesis, University of Toronto.
Fleischmajer, R., and Nedwich, A., 1973a, Progeria (Hutchinson-Gilford), Arch. Dermatol. 107: 253–258.
Fleischmajer, R., and Nedwich, A., 1973b, Werner’s syndrome, Am. J. Med. 54: 111–118.
Forbes, A. P., and Engel, E., 1963, The high incidence of diabetes mellitus in 41 patients with onadal dysgenesis and their close relatives, Metabolism 12:428–439.
Ford, C. E., Kones, K. W., Polani, P. E., DeAlmeida, J. C., and Briggs, J. H., 1959, A sex chromosome anomaly in a case of gonadal dysgenesis (Turner’s syndrome) Lancet 1:711.
Franceschetti, A., 1953, Les dysplasies ectodermiques et les syndromes héréditaires apparantes, Dermatologica 106:129–156.
Franks, L. M., 1972, The ultrastructure of tissue culture cells, Symp. Biol. Hung. 14:31–35.
Fraser, G. R., and Friedmann, A. I., 1967, The Causes of Blindness in Childhood: A Study of 776 Children with Severe Visual Handicaps, Johns Hopkins University Press, Baltimore.
Fratontoni, J. C., Hall, C. W., and Neufeld, E. F., 1968, Hurler and Hunter syndromes: Mutual correction of the defect in cultured fibroblasts, Science 162:570–572.
Frenkel, G., 1970, Mucosal atrophy with special reference to the Werner syndrome, Dtsch. Zahnaerztl. Z. 25:1026–1029.
Friedman, J. M., and Fialkow, P. J., 1976, Cell marker studies of human tumorigenesis, Transplant. Rev. 28:17–33.
Fujimoto, W. Y., Green, M. L., and Seegmiller, J. E., 1969, Cockayne’s syndrome: Report of a case with hyperlipoproteinemia, hyperinsulinemia, renal disease, and normal growth hormone, J. Pediatr. 75:881–884.
Gabr, M., Hashem, N., Hashem, F., Fahmi, A., and Safouh, M., 1960, Progeria, a pathologic study, J. Pediatr. 57:70–77.
Galloway, S. M., and Evans, H. J., 1975, Sister chromatid exchange in human chromosomes from normal individuals and patients with ataxia telangiectasia, Cytogenet. Cell Genet. 15:17–29.
Gardner, D. G., and Majka, M., 1969, The early formation of irregular secondary dentine in progeria, Oral Surg. Oral Med. and Oral Pathol. 28:877–884.
Gerald, P. S., 1976, Current concepts in genetics—Sex chromosome disorders, N. Engl. J. Med. 294:706–708.
German, J., 1974, Chromosomes and Cancer, John Wiley & Sons, New York.
Gershon, D., and Gershon, H., 1976, An evaluation of the “error catastrophe” theory of ageing in the light of recent experimental results, Gerontology 22:212–219.
Ghosh, S., and Berry, A. M., 1973, Progeria—A follow up of 8 years, Indian Pediatr. 10:45.
Ghosh, S., and Varma, K. P. S., 1964, Progeria: Report of a case with review of the literature, Indian Pediatr. 1:146–155.
Giacomini, F., and Rizzi, B., 1968, Considerations on the osteogenic healing process in a case of true progeria, Arch. Ortop. 81:379–389.
Gibbs, D. D., 1967, Werner’s syndrome (progeria of the adult), Proc. R. Soc. Med. 60:135–136.
Gilford, H., 1897, On the condition of mixed premature and immature development, Trans. Med.-Chir. Soc. Edinburgh 80:17–45.
Gilkes, J. J., Sharvill, D. E., and Wells, R. S., 1974, The premature ageing syndromes: Report of eight cases and description of a new entity named metageria, Br. J. Dermatol. 91:243–262.
Ginsberg-Fellner, F., and Knittle, J. L., 1973, Adipose tissue cellularity and metabolism in newly diagnosed juvenile diabetics, Diabetes 22:528–536.
Goetz, I., Roberts, E., and Comings, D. E., 1975, Fibroblasts in Huntington’s disease, N. Engl. J. Med. 293:1225–1227.
Gold, P., 1971, Antigenic reversion in human cancer, Annu. Rev. Med. 22:85–94.
Goldstein, D. E., Drash, A., Gibbs, J., and Blizzard, R. M., 1970, Diabetes mellitus: The incidence of circulating antibodies against thyroid, gastric and adrenal tissue, J. Pediatr. 77:304–306.
Goldstein, S., 1969, Lifespan of cultured cells in progeria, Lancet 1:424.
Goldstein, S., 1971a, The biology of aging, N. Engl. J. Med. 285: 1120–1129.
Goldstein, S., 1971b, On the pathogenesis of diabetes mellitus and its relationship to biological aging, Humangenetik 12: 83.
Goldstein, S., 1971c, The role of DNA repair in aging of cultured fibroblasts from Xeroderma pigmentosum and normals, Proc. Soc. Exp. Biol. Med. 137: 730–734.
Goldstein, S., 1978a, Senescence. I. Hormones and aging, in: Metabolic Basis of Endrocrinology (Degroot, Martins, Potts, Nelson, Winegrad, Odell, Steinberger, and Cahill, eds.), Grune and Stratton, New York (in press).
Goldstein, S., 19786, Senescence. II. General and cellular aging, in: Metabolic Basis of Endocrinology (Degroot, Martins, Potts, Nelson, Winegrad, Odell, Steinberger, and Cahill, eds.), Grune and Stratton, New York (in press).
Goldstein, S., and Moerman, E., 1975a, Heat-labile enzymes in skin fibroblasts from subjects with progeria, N. Engl. J. Med. 292: 1305–1309.
Goldstein, S., and Moerman, E. J., 1975b, Heat-labile enzymes in Werner’s syndrome fibroblasts, Nature (London) 255: 159.
Goldstein, S., and Moerman, E. J., 1976a, The Hutchinson—Gilford (progeria) syndrome: Heat-lability of enzymes, in red blood cells in a family, Clin. Res. 24:668A.
Goldstein, S., and Moerman, E. J., 1916b, Defective proteins in normal and abnormal human fibroblasts during aging in vitro, Interdiscip. Top. Gerontol. 10: 24–43.
Goldstein, S., and Niewiarowski, S., 1976, Increased procoagulant activity in cultured fibroblasts from progeria and Werner’s syndromes of premature ageing, Nature (London) 260:711–713.
Goldstein, S., and Singal, D. P., 1974, Alteration of fibroblast gene products in vitro from a subject with Werner’s syndrome, Nature (London) 251:719–721.
Goldstein, S., and Trieman, G., 1975, Glucose consumption by early and late-passage diploid human fibroblasts during growth and stationary phase, Experientia 31:177–180.
Goldstein, S., Littlefield, J. W., and Soeldner, J. S., 1969, Diabetes mellitus and aging: Diminished plating efficiency of cultured human fibroblasts, Proc. Natl. Acad. Sci. U.S.A. 64:155–160.
Goldstein, S., Moerman, E. J., Soeldner, J. S., Gleason, R. E., and Barnett, D. M., 1974, Diabetes mellitus and prediabetes: Decreased replicative capacity of cultured fibroblasts, J. Clin. Invest. 53: 27a–27b.
Goldstein, S., Niewiarowski, S., and Singal, D. P., 1975, Pathological implications of cell aging in vitro, Fed. Proc. Fed. Am. Soc. Exp. Biol. 34:56–63.
Goldstein, S., Stotland, D., and Cordeiro, R. A. J., 1976, Decreased proteolysis and increased amino acid efflux in aging human fibroblasts. Mech. Agein Dev. 5:221–233.
Goldstein, S., Moerman, E. J., Soeldner, J. S., Gleason, R. E., and Barnett, D. M., 1978, Chronologic age and physiologic status: Effect on replicative lifespan of cultured human fibroblasts from diabetic, prediabetic and normal donors, Science (in press).
Good, R. A., and Yunis, E., 1974, Association of autoimmunity, immunodeficiency and aging in man, rabbits and mice, Fed. Proc. Fed. Am. Soc. Exp. Biol. 33:2040–2050.
Gotoff, S. P., Amirmokri, E., and Liebner, E. J., 1967, Ataxia telangiectasia, neoplasia, untoward response to X-irradiation, and tuberous sclerosis, Am. J. Dis. Child. 114:617–625.
Gottron, H., 1940, Familiare akrogerie, Arch. Dermatol. Syphilol. 181:571–583.
Greene, M. L., Glueck, C. J., Fujimoto, W. Y., and Seegmiller, J. E., 1970, Benign symmetric lipomatosis (Launois-Bensaude adenolipomatosis) with gout and hyperlipoproteinemia, Am. J. Med. 48: 239–246.
Griffin, J. E., Punyashthiti, K., and Wilson, J. D., 1976, Dihydrotestosterone binding by cultured human fibroblasts: Comparison of cells from control subjects and from patients with hereditary male pseudohermaphroditism due to androgen resistance, J. Clin. Invest. 57:1342–1351.
Grunebaum, M., 1973, Progeria, Postgrad. Med. 53:221–222.
Gsell, O., and Haensch, G., 1971, Werner’s syndrome: A case report on premature aging, Schweiz. Med. Wochenschr. 101:418–421.
Haerer, A. F., Jackson, J. F., and Evers, C. G., 1969, Ataxia-telangiectasia with gastric adenocarcinoma, J. Am. Med. Assoc. 210:1884–1887.
Hall, B. D., Berg, B. O., Rudolph, R. S., and Epstein, C. J., 1974, Pseudoprogeria-Hallermann-Streiff (PHS) syndrome, Birth Defects: Orig. Artic. Ser. 10:137–146.
Hamlin, C. R., Kohn, R. R., and Luschin, J. H., 1975, Apparent accelerated aging of human collagen in diabetes mellitus, Diabetes 24:902–904.
Harnden, D. G., 1974, Ataxia telangiectasia syndrome: Cytogenetic and cancer aspects, in: Chromosomes and Cancer (J. German, ed.), pp. 619–636, John Wiley & Sons, New York.
Hart, R. W., and Trosko, J. E., 1976, DNA repair processes in mammals, Interdiscip. Top. Gerontol. 9:134–167.
Haslam, R. J., and Goldstein, S., 1974, Adenosine 3′:5′-cyclic monophosphate in young and senescent human fibroblasts during growth and stationary phase in vitro: Effects of prostaglandin E1 and of adrenaline, Biochem. J. 144:253–263.
Hassell, T. M., Page, R. C., Narayanan, S., and Cooper, C. G., 1976, Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced abnormality of connective tissue, Proc. Natl. Acad. Sci. U.S.A. 73:2909–2912.
Hayflick, L., 1965, The limited in vitro lifetime of human diploid cell strains, Exp. Cell Res. 37:614–636.
Hecht, F., Koler, R. D., Rigas, D. A., Dahnke, G. S., Case, M. P., Tisdale, V., and Miller, R. W., 1966, Leukemia and lymphocytes in ataxia-telangiectasia, Lancet 2:1193.
Hecht, F., McCaw, B. K., and Koler, R. D., 1973, Ataxia-telangiectasia-Clonal growth of translocation lymphocytes, N. Engl. J. Med. 289:286–291.
Hernandez, A. L., DeLeon, B., Garcia de la Puenti, S., and Del Castillo, V., 1975, Ultrastructural renal lesions in the Cockayne syndrome: A case report, Rev. Invest. Clin. 27:153–158.
Higurashi, M., and Conen, P. E., 1973, In vitro chromosomal radiosensitivity in chromosomal breakage syndromes, Cancer 32:380–383.
Hoar, D. I., 1975, Phenotypic manifestations of ataxia-telangiectasia, Lancet 2:1048.
Hoar, D. I., and Sargent, P., 1976, Chemical mutagen hypersensitivity in ataxia-telangiectasia, Nature (London) 261:590–592.
Holliday, R., Porterfield, J. S., and Gibbs, D. D., 1974, Premature ageing and occurrence of altered enzyme in Werner’s syndrome fibroblasts, Nature (London) 248:762–763.
Hopkins, D. J., and Horan, E. C., 1970, Glaucoma in the Hallermann-Streiff syndrome, Br. J. Ophthalmol. 54:416–422.
Hoppe, W., and Koritsch, H. D., 1972, Another case of meningioma in a patient with Werner’s syndrome, Psychiatr. Neurol. Med. Psychol. 24:611–617.
Howell, T. H., 1975, Old Age, p. 115, H. K. Lewis, London.
Huang, K.-E., 1975, Pituitary response to synthetic luteinizing hormone-releasing hormone in patients with Turner’s syndrome, J. Clin. Endocrinol. Metab. 41:771–776.
Huang, S.-W., and Maclaren, N. K., 1976, Insulin-dependent diabetes: A disease of autoaggression, Science 192:64–66.
Hutchinson, D., 1971, Oral manifestations of oculomandibulodyscephaly with hypotrichosis (Hallermann-Streiff syndrome), Oral Surg. Oral Med. Oral Pathol. 31:234–244.
Hutchinson, J., 1886, Congenital absence of hair and mammary glands, Trans. Med.-Chir. Soc. Edinburgh 69:473–477.
Ishii, T., 1976, Progeria: Autopsy report of one case, with a review of pathologic findings reported in the literature, J. Am. Geriatr. Soc. 24:193–202.
Ishii, T., and Hosoda, Y., 1974, Autopsy of Werner’s syndrome, Jpn. J. Geriatr. 11:408–415.
Ishii, T., and Hosoda, Y., 1975, Werner’s syndrome: Autopsy report of one case, with a review of pathologic findings reported in the literature, J. Am. Geriatr. Soc. 23:145–154.
Jervis, G. A., 1970, Premature senility in Down’s syndrome, Ann. N. Y. Acad. Sci. 171:559–561.
Johansen, K. Soeldner, J. S., Gleason, R. E., Gottlieb, M. S., Park, B. N., Kaufmann, R. L., and Tan, M. H., 1975, Serum insulin and growth hormone response patterns in monozygotic twin siblings of patients with juvenile-onset diabetes, N. Engl. J. Med. 293:57–61.
Jones, K. L., Smith, D. W., Harvey, M. A., Hall, B. D., and Quan, L., 1975, Older paterna age and fresh gene mutation: Data on additional disorders, J. Pediatr. 86:84–88.
Kaiman, H., Lambie, R. W., and Metzl, 1969, Progeria: Case description, Clin. Pediatr. (Philadelphia) 8:411–415.
Kato, H., and Stich, H. F., 1976, Sister chromatid exchanges in aging and repair-dehcient human fibroblasts, Nature (London) 260:447–448.
Kaufman, M., Straisfeld, C., and Pinsky, L., 1977, Expression of androgen-responsive properties in human skin fibroblast strains of genital and nongenital origin, Somat. Cell Genet. 3:17–25.
Keay, A. J., Oliver, M. F., and Boyd, G. S., 1955, Progeria and atherosclerosis, Arch. Dis. Child. 30:410–414.
Kidd, R. L., and Wilgram, G. F., 1972, Morphea and progeria, Arch. Dermatol. 105:770–771.
Kohn, R. R., 1975, Aging and cell division, Science 188:203–204.
Korein, J., Steinman, P. A., and Senz, E. H., 1961, Ataxia-telangiectasia: Report of a case and review of the literature, Arch. Neurol. 4:272–280.
Kraus, B. S., Gottlieb, M. A., and Meliton, H. R., 1970, The dentition in Rothmund’s syndrome, J. Am. Dent. Assoc. 81:895–915.
Kristensen, J. K., 1975, Poikiloderma congénitale—An early case of Rothmund-Thomson’s syndrome, Ada Derm.-Venereol. 55:316–318.
Kulenkamp, D., Scholz-Kordan, D., Passarge, E., Rudiger, H. W., and Ruprecht, K. W., 1973, Werner’s syndrome: A hereditable disorder of multiple organ systems, Andrologie 5:299–310.
Kvale, P. A., Rutt, W. M., Birk, R. E., and Eyler, W. R., 1965, Werner’s syndrome, Henry Ford Hosp. Med. J. 13:411–420.
Land, V. J., and Nogrady, M. B., 1969, Cockayne’s syndrome, J. Can. Assoc. Radiol. 20:194–203.
Lanning, M., and Simil, A. S., 1970, Cockayne’s syndrome: Report of a case with normal intelligence, Z. Kinderheilkd. 109:70–75.
Larregue, M., Cathelineau, G., Binet, O., Lhullier, N., Timsit, E., and Graciansky, P. De, 1974, Werner’s syndrome and hyperinsulinic diabetes, Ann. Dermatol. Syphiligr. 101:135–144.
Latt, S. A., Stetten, G. M., Juergens, L. A., Buchanan, G. R., and Gerald, P. S., 1975, Induction by alklyating agents of sister chromatid exchanges and chromatid breaks in Fanconi’s anemia, Proc. Natl. Acad. Sci. U.S.A. 72:4066–4070.
Leaf, A., 1973, Unusual longevity: The common denominator, Hosp. Pract. 8:79–86.
Le Guilly, Y., Simon, M., Lenoir, P., and Bourel, M., 1973, Long-term culture of human adult liver cells: Morphological changes related to in vitro senescence and effect of donor’s age on growth potential, Gerontologia 19:303–313.
Lelis, I. I., 1975, Progeria of adults (Werner’s syndrome) Ter. Arkh. 47(1):99–102.
Lenz, W. D., and Majewski, F., 1974, A generalized disorder of the connective tissues with progeria, choanal atresia, symphalangism, hypoplasia of dentine and craniodiaphyseal hypostosis, Birth Defects: Orig. Artic. Ser. 10:133–136.
Lestradet, H., Deschamps, I., and Giron, B., 1976, Insulin and free fatty acid levels during oral glucose tolerance tests and their relation to age in 70 healthy children, Diabetes 25:505–508.
Levin, S., and Perlov, S., 1971, Ataxia-telangiectasia in Israel, with observations on its relationship to malignant disease, Isr. J. Med. Sci. 7:1535–1541.
Levine, M. D., Alexander, E., and Rimoin, D. L., 1975, Progeroid syndrome, Birth Defects: Orig. Artie. Ser. 11:308–309.
Lewis, M. B., 1972, Rothmund-Thomson syndrome and fibrocystic disease, Australas. J. Dermatol. 13:105–106.
Lieberman, M. W., 1976, Approaches to the analysis of fidelity of DNA repair in mammalian cells, Int. Rev. Cytol. 45:1–23.
Like, A. A., and Rossini, A. A., 1976, Streptozotocin-induced pancreatic insulitis: A new model of diabetes mellitus, Science 193:415–417.
Lindeman, R. D., 1975, Age changes in renal function, in: The Physiology and Pathology of Human Aging (R. Goldman and M. Rockstein, eds.), pp. 19–38, Academic Press, New York.
Lindsten, J., 1963, in: The Nature and Origin of X Chromosome Aberrations in Turner’s Syndrome (Almquist and Wiksell, eds.), Stockholm.
Lindsten, J., Cerasi, E., Luft, R., and Hultquist, G., 1967, The occurrence of abnormal insulin and growth hormone (HGH) responses to sustained hyperglycaemia in a disease with sex chromosome aberrations (Turner’s syndrome): Including a histological study of the pancreas in two such patients, Acta Endocrinol.(Copenhagen) 56: 107–131.
Linn, S., Kairis, M., and Holliday, R., 1976, Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts, Proc. Natl. Acad. Sci. U.S.A. 73:2818–2822.
Lisker, R., and Cobo, A., 1970, Chromosome breakage in ataxia-telangiectasia, Lancet 1:618.
Little, J. B., Epstein, J., and Williams, J. R., 1975, Repair of DNA strand breaks in progeric fibroblasts and aging human diploid cells, Basic Life Sci. 58:793–800.
Lodi, A., Ravaglia, G., Grigioni, F., Ravaioli, R., and Gritti, F., 1974, Endocrine and morphological aspects of Werner’s syndrome, J. Clin. Med. 55:652–674.
Louis-Bar, D., 1941, Sur un syndrome progressif comprenant des télangiectasies capillaires cutanées et conjonctivales, à disposition naevoïde et des troubles cérébelleux, Confin. Neurol. 4:32–42.
MacDonald, W. B., Fitch, K. D., and Lewis, I. C., 1960, Cockayne’s syndrome: A heredo-familial disorder of growth and development, Pediatrics 25:997–1007.
Macleod, W., 1966, Progeria, Br. J. Radiol. 39:224–226.
MacNamara, B. G., Farn, K. T., Mitra, A. K., Lloyd, J. K., and Fosbrooke, A. S., 1970, Progeria: Case report with long-term studies of serum lipids, Arch. Dis. Child. 45:553–560.
Malamud, N., 1972, Neuropathology of organic brain syndromes associated with aging, in: Aging and the Brain (CM. Gaitz, ed.), pp. 63–87, Plenum Press, New York.
Marble, A., and Ramos, E., 1971, Cancer and diabetes, in: Joslin’s Diabetes Mellitus (A. Marble, P. White, R. F. Bradley, and L. P. Krall, eds.), pp. 695–700, Lea & Febiger, Philadelphia.
Marcondes, E., Campos, J. V., Barbieri, D., Quarentei, G., and Cavallo, A., 1969, Progeria: Case report with progressive systemic sclerotic manifestations since birth, Rev. Hosp. Clin. Fac. Med. Univ. Sao Paulo 24:147–154.
Margolin, F. R., and Steinbach, H. L., 1968, Progeria: Hutchinson-Gilford syndrome, Am. J. Roentgenol. Radium Ther. Nucl. Med. 103:173–178.
Marks, H. H., and Krall, L. P., 1971, Onset, course, prognosis and mortality in diabetes mellitus, in: Joslin’s Diabetes Mellitus (A. Marble, P. White, R. F. Bradley, and L. P. Krall, eds.), pp. 209–254, Lea & Febiger, Philadelphia.
Martin, G. M., 1977, Genetic syndromes in man with potential relevance to the pathobiology of aging, in: Genetic Effects on Aging, Birth Defects: Orig. Artic. Ser. (D. Bergsma and D. E. Harrison, eds.) The National Foundation-March of Dimes, New York (in press).
Martin, G. M., Sprague, CA., and Epstein, C.J., 1970, Replicative life-span of cultivated human cells: Effects of donor’s age, tissue, and genotype, Lab. Invest. 23:86–92.
Martin, G. M., Sprague, C. A., Norwood, T. H., and Pendergrass, W. R., 1974, Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia, Am. J. Pathol. 74:137–154.
Martin, J. J., Deberot, R., Philippart, M., Van Acker, K. J., and Hooft, C., 1971, Peculiar dysmorphic syndrome with orthochromatic leucodystrophy: Discussion of its relationship with Cockayne’s syndrome and Pelizaeus-Merzbacher’s disease, Acta Neuropathol. 18:224–233.
Maurer, R. M., and Langford, O. L., 1967, Rothmund’s syndrome: A cause of résorption of phalangeal tufts and dystrophic calcification, Radiology 89:706–708.
McCaw, B. K., Hecht, F., Harnden, D. G., and Teplitz, R. L., 1975, Somatic rearrangement of chromosome 14 in human lymphocytes, Proc. Natl. Acad. Sci. U.S.A. 72:2071–2075.
McFarlin, D. W., Strober, W., and Waldmann, T. A., 1972, Ataxia telangiectasia, Medicine (Baltimore) 51:281–314.
McKusick, V. A., 1963, Medical genetics, 1962, J. Chronic Dis. 16:457–634.
McKusick, V. A., 1975, Mendelian Inheritance in Man—Catalogs of Autosomal Dominant, Autosomal Recessive and X-Linked Phenotypes, Johns Hopkins University Press, Baltimore.
McKusick, V. A., and Cross, H. E., 1966, Ataxia-telangiectasia and Swiss-type agammaglobulinemia: Two genetic disorders of the immune mechanism in related Amish sibships, J. Am. Med. Assoc. 195:739–745.
Meissner, W. A., and Legg, M. A., 1971, The pathology of diabetes, in: Joslin’s Diabetes Mellitus (A. Marble, P. White, R. F. Bradley, and L. P. Krall, eds.), pp. 157–190, Lea & Febiger, Philadelphia.
Menkes, J. H., and Stein, N., 1973, Fibroblast cultures in Huntington’s disease, N. Engl. J. Med. 288:856–857.
Miller, M. E., and Chatten, J., 1967, Ovarian changes in ataxia telangiectasia, Acta Paediatr. Scand. 56:559–561.
Miller, R. W., 1970, Neoplasia and Down’s syndrome, Ann. N. Y. Acad. Sci. 171:637–644.
Moosa, A., and Dubowitz, V., 1970, Peripheral neuropathy in Cockayne’s syndrome, Arch. Dis. Child. 45:674–677.
Moossey, J., 1967, The neuropathology of Cockayne’s syndrome, J. Neuropathol. Exp. Neurol. 26:654–660.
Morgan, J. L., Holcomb, T. M., and Morrissey, R. W., 1968, Radiation reaction in ataxia telangiectasia, Am. J. Dis. Child. 116:577–558.
Morse, L. S., and Pauling, C., 1975, Induction of error-prone repair as a consequence of DNA ligase deficiency in E. coli, Proc. Natl. Acad. Sci. U.S.A. 72:4645–4649.
Mostafa, A. H., and Gabr, M., 1954, Heredity in progeria: With follow-up of two affected sisters, Arch. Pediatr. 71:163–172.
Muller, J., Kunkov, A. A., and Kepertov, A. A., 1969, Werner’s syndrome: Case report, Wien. Z. Inn. Med. Ihre Grenzgeb. 50:112–116.
Murphy, R., and Achkar, E. J., 1966, Werner’s syndrome, Lahey Clin. Found. Bull. 15: 1–7.
Neill, C. A., and Dingwall, M. M., 1950, A syndrome resembling progeria: A review of two cases, Arch. Dis. Child. 25: 213–223.
Nelson, P. G., Pyke, D. A., Cudworth, A. G., Woodrow, J. C., and Batchelor, J. R., 1975, Histocompatibility antigens in diabetic identical twins, Lancet 2:193–194.
Neufeld, E. F., Lim, T. W., and Shapiro, L. J., 1975, Inherited disorders of lysosomal metabolism, Annu. Rev. Biochem. 44:357–376.
Nielsen, J., Johansen, K., and Yde, H., 1969, The frequency of diabetes mellitus in patients with Turner’s syndrome and pure gonadal dysgenesis, Acta Endocrinol. (Copenhagen) 62:251–269.
Nienhaus, A. J., De Jong, B., and Kate, L. P. Ten, 1971, Fibroblast culture in Werner’s syndrome, Humangenetik 13:244–246.
Nissim, J. E., 1971, Rothmund syndrome, Birth Defects: Orig. Artie. Ser. 7:294–295.
Norman, R. M., and Tingey, A. H., 1966, Syndrome of micrencephaly, strio-cerebellar calcifications and leucodystrophy, J. Neurol. Neurosurg. Psychiatry 29:157–163.
Nowell, P. C., 1976, The clonal evolution of tumor cell populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression, Science 194:23–28.
Oates, R. K., Lewis, M. B., and Walker-Smith, J. A., 1971, The Rothmund-Thomson syndrome: Case report of an unusual syndrome, Aust. Paediatr. J. 7:103–107.
Ohno, T., and Hiroaka, M., 1966, Renal lesions in Cockayne’s syndrome, Tohoku J. Exp. Med. 89:151–166.
Orgel, L. E., 1973, Ageing of clones of mammalian cells, Nature (London) 243: 441–445.
Oxford, J. M., Harnden, D. G., Parrington, J. M., and Delhanty, J. D., 1975, Specific chromosome aberrations in ataxia telangiectasia, J. Med. Genet. 12:251–262.
Ozonoff, M. B., and Clemett, A. R., 1967, Progressive osteolysis in progeria, Am. J. Roentgenol. Radium Ther. Nucl. Med. 100:75–79.
Paddison, R. M., Moossy, J., Derbes, V. J., and Kloepfer, H. W., 1963, Cockayne’s syndrome: A report of five new cases with biochemical, chromosomal, dermatologie, genetic and neuropathologic observations, Dermatol. Trop. Ecol. Geogr. 2:195–203.
Palmer, G., 1966, Rothmund-Thomson syndrome, Australas. J. Dermatol. 8:253–254.
Palumbo, P. J., Elveback, L. R., Chu, C.-P., Connolly, D. C., and Kurland, L. T., 1976, Diabetes mellitus: Incidence, prevalence, survivorship, and causes of death in Rochester, Minnesota, 1945-1970, Diabetes 25:566–573.
Paterson, D., 1922, Case of progeria, Proc. R. Soc. Med. 16:42.
Paterson, M. C., Smith, B. P., Lohman, P. H. M., Anderson, A. K., and Fishman, L., 1976, Defective excision repair of ϒ-ray-damaged DNA in human (ataxia telangiectasia) fibroblasts, Nature (London) 260:444–447.
Payer, G., 1969, Two cases of Werner’s syndrome, Klin. Monatsbl. Augenheilkd. 155:901–904.
Penrose, L. S., and Smith, G. F., 1966, Down’s Anomaly, Churchill, London.
Perlman, H. H., Luscombe, H. A., and Rosenberg, P. E., 1967, Poikiloderma congénitale of Thomson-Rothmund vs. localized linear scleroderma, Arch. Dermatol. 96:593–594.
Perry, R. P., 1976, Processing of RNA, Annu. Rev. Biochem. 45:605–630.
Peterson, R. D. A., Kelly, W. D., and Good, R. A., 1964, Ataxia-telangiectasia: Its association with a defective thymus, immunological-deficiency disease and malignancy, Lancet 1:1189–1193.
Peterson, R. D. A., Cooper, M. D., and Good, R. A., 1966, Lymphoid tissue abnormalities associated with ataxia-telangiectasia, Am. J. Med. 41:342–359.
Pfeiffer, R. A., and Backmann, K. D., 1973, An atypical case of Cockayne’s syndrome, Clin. Genet. 4:28–32.
Piazzini, M., Conti, C., Guazzelli, R., and Bigozzi, U., 1976, On a rare case of progeria in brother and sister, Acta Med. Auxol. 8:75–79.
Poon, P. K., O’Brien, R. L., and Parker, J. W., 1974, Defective DNA repair in Fanconi’s anaemia, Nature (London) 250:223–225.
Predescu, V., Christodorescu, D., Coltoiu, A., Costiner, E., Hagiopol, V., and Alexianu, M., 1973, Cockayne’s syndrome, Arch. Fr. Pediatr. 30:527–532.
Rainbow, A. J., and Howes, M., 1977, Decreased repair of gamma ray damaged DNA in progeria, Biochem. Biophys. Res. Commun. 77:714–719.
Rary, J. M., Bender, M. A., and Kelly, T. E., 1975, A 14/14 marker chromosome lymphocyte clone in ataxia telangiectasia, J. Hered. 66:33–35.
Rasio, E., Antaki, A., and Van Campenhout, J., 1976, Diabetes mellitus in gonadal dysgenesis: Studies of insulin and growth hormone secretion, Eur. J. Clin. Invest. 6:59–66.
Rava, G., 1967, Su un nucleo familiare di progeria, Minerva Med. 58:1502–1509.
Regan, J. D., and Setlow, R. B., 1974, DNA repair in human progeroid cells, Biochem. Biophys. Res. Common. 59:858–864.
Reichel, W., and Garcia-Bunuel, R., 1970, Pathologic findings in progeria: Myocardial fibrosis and lipofuscin pigment, Am. J. Clin. Pathol. 53:243–253.
Reichel, W., Garcia-Bunuel, R., and Dilallo, J., 1971a, Progeria and Werner’s syndrome as models for the study of normal human aging, J. Am. Geriatr. Soc. 19: 369–375.
Reichel, W., Bailey, J. A., Zigel, S., Garcia-Bunuel, R., and Knox, G., 1971b, Radiological findings in progeria, J. Am. Geriatr. Soc. 19:657–674.
Reiss, U., and Gershon, D., 1976, Rat liver Superoxide dismutase: Purification and age-related modifications, Eur. J. Biochem. 63:617–623.
Remsen, J. F., and Cerutti, P. A., 1976, Deficiency of gamma-ray excision repair in skin fibroblasts from Fanconi’s anemia, Proc. Natl. Acad. Sci. U.S.A. 73:2419–2423.
Renold, A. E., Stauffacher, W., and Cahill, G. F. Jr., 1972, Diabetes mellitus, in: The Metabolic Bases of Inherited Disease (J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds.), pp. 83–118, McGraw-Hill, New York.
Reye, C., and Mosman, N. S. W., 1960, Ataxia-telangiectasia, Am. J. Dis. Child. 99:238–247.
Reynolds, C., O’Duffy, J. D., and Sams, W., 1972, Werner’s syndrome: Case report of a variant, Minn. Med. 55:917–921.
Rheinwald, J. G., and Green, H., 1975, Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells, Cell 6:331–337.
Richards, D., 1974, Werner’s syndrome, Proc. R. Soc. Med. 67:721–722.
Riggs, W., and Seibert, J., 1972, Cockayne’s syndrome: Roentgen findings, Am. J. Roentgenol. Radium Ther. Nucl. Med. 116:623–633.
Rosen, R. S., Cimini, R., and Coblentz, D., 1970, Werner’s syndrome, Br. J. Radiol. 43:193–198.
Rosenbloom, A. L., and Debusk, F. L., 1971, Progeria of Hutchinson-Gilford: A caricature of aging, Am. Heart J. 83:287–289.
Rosenbloom, A. L., Karacan, I. J., and DeBusk, F. L., 1970, Sleep characteristics and endocrine response in progeria, J. Pediatr. 77:692–695.
Rosenbloom, A. L., Wheeler, L., Bianchi, R., Chin, F. T., Tiwary, C. M., and Grgic, A., 1975, Age-adjusted analysis of insulin responses during normal and abnormal glucose tolerance tests in children and adolescents, Diabetes 24:820–828.
Rosenbloom, A. L., Goldstein, S., and Yip, C. C., 1976, Insulin binding to cultured human fibroblasts increases with normal and precocious aging, Science 193:412–415.
Rothmund, A., 1868, Über Kataracten in Verbindung mit einer eigenthen Haut Degeneration, Graefe. Arch. Ophthalmol. 14:159–182.
Rothstein, M., 1977, Recent developments in the age-related alteration of enzymes: A review, Mech. Ageing Dev. 6:241–257.
Rowe, J. W., Andres, R., Tobin, J. D., Norrs, A. H., and Shock, N. W., 1976, The effect of age on creatinine clearance in man: A cross-sectional and longitudinal study, J. Gerontol. 31:155–163.
Rowlatt, U., 1969, Cockayne’s syndrome: Report of case with necropsy findings, Acta Neuropathol. 14:52–61.
Roy, S., Srivastava, R. N., Gupta, P. C., and Mayekar, G., 1973, Ultrastructure of peripheral nerve in Cockayne’s syndrome, Acta Neuropathol. 24:345–349.
Roychoudhury, D. S., and Banerjee, A. K., 1968, Heredofamilial study of Weber-Cockayne disease, Bull. Calcutta Sch. Trop. Med. 16:12–13.
Rubin, P., and Casarett, G. W., 1968, Clinical Radiation Pathology, pp. 881–893, W. B. Saunders Co., Philadelphia.
Ruddle, F. H., and Creagan, R. P., 1975, Parasexual approaches to the genetics of man, Annu. Rev. Genet. 9:407–486.
Ryan, J. M., and Cristofalo, V. J., 1975, Chromatin template activity during aging in vitro, Exp. Cell Res. 90:456–458.
Saunders, J. W., and Fallon, J. F., 1966, Cell death in morphogenesis, in: Major Problems in Developmental Biology (M. Locke, ed.), pp. 289–314, Academic Press, New York.
Schalch, D. S., McFarlin, D., and Barlow, M. H., 1970, An unusual form of diabetes mellitus in ataxia telangiectasia, N. Engl. J. Med. 282:1396–1402.
Schmickel, R. D., Chu, E. H. Y., and Trosko, J., 1975, The definition of a cellular defect in two patients with Cockayne syndrome, Pediatr. Res. 9: 317 (abstract).
Schneider, E. L., and Chase, G. A., 1976, Relationship between age of donor and in vitro life span of human diploid fibroblasts, Interdiscip. Top. Gerontol. 10:62–69.
Schneider, E. L., and Epstein, C. J., 1972, Replication rate and lifespan of cultured fibroblasts in Down’s syndrome, Proc. Soc. Exp. Biol. Med. 141:1092–1096.
Schneider, E. L., and Mitsui, Y., 1976, The relationship between in vitro cellular aging and in vivo human age, Proc. Natl. Acad. Sci. U.S.A. 73:3584–3588.
Schneider, E. L., and Shorr, S. S., 1975, Alteration in cellular RNA’s during the in vitro lifespan of cultured human diploid fibroblasts, Cell 6:179–184.
Schumacher, K., Rodermund, O. E., and Doepfmer, R., 1969, Werner’s syndrome: Contribution to symptomatology and etiology, Arch. Klin. Med. 216:116–147.
Segal, D. J., and McCoy, E. E., 1974, Studies on Down’s syndrome in tissue culture. I. Growth rates and protein contents of fibroblast cultures, J. Cell. Physiol. 83:85–90.
Sexton, G. B., 1954, Thomson’s syndrome (poikiloderma congénitale), Can. Med. Assoc. J. 70:662–665.
Shuster, J., Hart, Z., Stimson, C. W., Brough, A. J., and Poulik, M. D., 1966, Ataxiatelangiectasia with cerebellar tumor, Pediatrics 37:776–786.
Siemens, H. W., 1963, The lens, in: Genetics and Ophthalmology (P. J. Waardenburg, A. Franceschetti, and D. Klein, eds.), p. 896, Charles C. Thomas, Springfield, Illinois. Silver, H. K., 1966, Rothmund-Thomson syndrome: An oculocutaneous disorder, Am. J. Dis. Child. 111:182–190.
Simig, I., and Fizelov, A. E., 1976, Werner’s syndrome, Cesk. Oftalmol. 32:45–49.
Singal, D. P., and Blajchman, M. A., 1973, Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus, Diabetes 22:429–432.
Singal, D. P., and Goldstein, S., 1973, Absence of detectable HL-A antigens on cultured fibroblasts in progeria, J. Clin. Invest. 52:2259–2263.
Smith, D. W., 1976, Ataxia-telangiectasia syndrome in: Recognizable Patterns of Human Malformation, pp. 102–103, W. B. Saunders Co., Philadelphia.
Smith, G. F., and Berg, J. M., 1976, Down’s Anomaly, pp. 239–246, Churchill Livingstone, Edinburgh.
Sourander, P., Bonnevier, J. O., and Olsson, Y., 1966, A case of ataxia telangiectasia with lesions in the spinal cord, Acta Neurol. Scand. 42:354–366.
Spark, H., 1965, Cachetic dwarfism resembling the Cockayne-Neill type, J. Pediatr. 66:41–47.
Spence, A. M., and Herman, M. M., 1973, Critical re-examination of the premature aging concept in progeria: A light and electron microscopic study, Mech. Ageing Dev. 2:211–227.
Sri-Skanda-Rajah-Sivayoham, I., and Ratnaike, V. T., 1975, Rothmund-Thomson syndrome in an Oriental patient, Ann. Ophthalmol. 7:417–420.
Srivastava, R. N., Gupta, P. C., Mayekar, G., and Roy, S., 1974, Cockayne’s syndrome in two sisters, Acta Paediatr. Scand. 63:461–464.
Stearns, E. L., MacDonnell, J. A., Kaufman, B. J., Padua, R., Lucman, T. S., Winter, J. S. D., and Faiman, C., 1974, Declining testicular function with age, Am. J. Med. 57:761–766.
Steele, R. W., and Bass, J. W., 1970, Hallermann-Streiff syndrome: Clinical and prognostic considerations, Am. J. Dis. Child. 120:462–465.
Stein, G. S., and Stein, J. L., 1976, In vitro studies of transcription as a function of age in mammalian cells, Interdiscip. Top. Gerontol. 10:83–99.
Strober, W., Wochner, R. D., Barlow, M. H., McFarlin, D. E., and Waldmann, T. A., 1968, Immunoglobulin metabolism in ataxia telangiectasia, J. Clin. Invest. 47:1905–1915.
Tadjoedin, M. K., and Fraser, F. C., 1965, Heredity of ataxia telangiectasia (Louis-Bar syndrome), Am. J. Dis. Child. 110:64–68.
Talbot, N. B., Butler, A. M., Pratt, E. L., MacLachlan, E. A., and Tannheimer, J., 1945, Progeria: Clinical, metabolic and pathologic studies on a patient, Am. J. Dis. Child. 69:267–279.
Tanenbaum, M. H., 1965, Werner’s syndrome: Progeria of the adult, Arch. Intern. Med. 116:499–504.
Tao, L. C., Stecker, E., and Gardner, H. A., 1971, Werner’s syndrome and acute myeloid leukemia, Can. Med. Assoc. J. 105:951–953.
Tattersall, R. B., and Fajans, S. S., 1975, A difference between the inheritance of classical juvenile-onset and maturity-onset type of diabetes of young people, Diabetes 24:44–53.
Taylor, A. M. R., Harnden, D. G., Arlett, C. F., Harcourt, S. A., Lehmann, A. R., Stevens, S., and Bridges, B. A., 1975, Ataxia telangiectasia: A human mutation with abnormal radiation sensitivity, Nature (London) 258:427–429.
Taylor, W. B., 1957, Rothmund’s syndrome—Thomson’s syndrome, Arch. Dermatol. 75:236–244.
Taymor, M. L., Toshihiro, A., and Pheteplace, C., 1968, Serum levels of FSH and LH by radioimmunoassay, in: Gonadotropins 1968, Proceedings of the Workshop Conference—Vista Hermosa, More., Mexico (Rosemberg, ed.), pp. 349–365, Geron-X, California.
Thannhauser, S. J., 1945, Werner’s syndrome (progeria of the adult) and Rothmund’s syndrome: Two types of closely related heredofamilial atrophic dermatosis with juvenile cataracts and endocrine features: A critical study with five new cases, Ann. Intern. Med. 23:559.
Thomsen, M., Platz, P., Ortved Andersen, O., Christy, M., Lyngsoe, J., Nerup, J., Rasmussen, K., Ryder, L. P., Staub Nelsen, L., and Svejgaard, A., 1975, MLC typing in juvenile diabetes mellitus and idiopathic Addison’s disease, Transplant. Rev. 22:125–147.
Thomson, M. S., 1936, Poikiloderma congénitale, Br. J. Dermatol. 48: 221–234.
Tibbetts, P. G., Rose, H. D., and Kersting, D. W., 1968, Werner’s syndrome, Wis. Med. J. 67: 550–557.
Tokunaga, M., Futami, T., Wakamatsu, E., Endo, M., and Yosizawa, Z., 1975, Werner’s syndrome as “hyaluronuria,” Clin. Chim. Acta 62:89–96.
Turner, H. H., 1938, A syndrome of infantilism, congenital webbed neck and cubitus valgus, Endocrinology 23:566–574.
Ufermann, K., Heege-Dohr, R., and Kosenow, W., 1973, Ocular manifestation in Cockayne’s syndrome, Klin. Monatsbl. Augenheilkd. 162:655–658.
Ungar, B., Stocks, A. E., Martin, F. I. R., Whittingham, S., and Mackay, I. R., 1968, Intrinsic factor antibody, parietal-cell antibody, and latent pernicious anemia in diabetes mellitus, Lancet 2:415–418.
Unger, R. H., 1976, Diabetes and the alpha cell, Diabetes 25:136–151.
Valdiserri, L., and Stricchiola, G., 1974, Hutchinson-Gilford progeria in a 14-year-old adolescent, Chir. Organi Mov. 61:291–300.
Van Campenhout, J., Antaki, A., and Rasio, E., 1973, Diabetes mellitus and thyroid autoimmunity in gonadal dysgenesis, Fertil. Steril. 24:1–9.
Vandaele, R., 1973, Werner’s syndrome: Familial ulcerous scleroderma with cataract and diabetes, Arch. Belg. Dermatol. Syphiligr. 29:251–254.
Viegas, J., Souza, P. L., and Salzano, F. M., 1974, Progeria in twins, J. Med. Genet. 11:384–386.
Villee, D. B., Nichols, G., Jr., and Talbot, N. B., 1969, Metabolic studies in two boys with classical progeria, Pediatrics 43: 207–216.
Vincent, R. A., Sheridan, R. B., and Huang, P. C., 1975, DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells, Mutat. Res. 33:357–366.
Vracko, R., and Benditt, E. P., 1974, Manifestations of diabetes mellitus: Their possible relationships to an underlying cell defect, Am. J. Pathol. 75:204–223.
Vracko, R., and Benditt, E. P., 1975, Restricted replicative life-span of diabetic fibroblasts in vitro: Its relation to microangiopathy, Fed. Proc. Fed. Am. Soc. Exp. Biol. 34:68–70.
Wahl, J. W., and Ellis, P. P., 1965, Rothmund-Thomson syndrome, Am. J. Ophthalmol. 60: 722–726.
Walburg, H. E., 1975, Radiation-induced life shortening and premature aging, Adv. Radiat. Biol. 5:145–179.
Waldmann, T. A., and McIntire, K. R., 1972, Serum-alpha-fetoprotein levels in patients with ataxia-telangiectasia, Lancet 2:1112–1115.
Wells, R. S., 1972, Werner’s syndrome: Acrogeria, Proc. R. Soc. Med. 65:525–526.
Welsh, O., 1975, Study of a family with a new progeroid syndrome, Birth Defects: Orig. Artie. Ser. 11:25–38.
Werder, E. A., Murset, G., Illig, R., and Prader, A., 1975, Hypogonadism and parathyroid adenoma in congenital poikiloderma (Rothmund-Thomson syndrome), Clin. Endocrinol. (Oxford) 4: 75–82.
Werner, O., 1904, Über Katarakt in Verbindung mit Sklerodermie (doctoral dissertation, Kiel University), Schmidt and Klaunig, Kiel, Germany.
Wertelecki, W., Fraumeni, J. F., and Mulvihill, J. J., 1970, Non-gonadal neoplasia in Turner’s syndrome, Cancer 26:485–488.
Wicks, A. C., and Wall, D. W., 1974, Werner’s syndrome: A case report in a Rhodesian African, Cent. Afr. J. Med. 20:251–254.
Wiedemann, H. R., 1969, Some progeroid cases and their diagnostic classification, Z. Kinderheilkd. 107:91–106.
Yasuhara, M., Kiyokane, K., Sakai, T., Oiwa, T., and Hashi, N., 1974, A case of Werner’s syndrome, Jpn. J. Hum. Genet. 19:86–87.
Zacharski, L. R., and McIntyre, O. R., 1973, Tissue factor (thromboplastin, Factor III) synthesis by cultured cells, J. Med. 4:118–131.
Zackai, A. H., Weber, D., and Noth, R., 1974, Cardiac findings in Werner’s syndrome, Geriatrics 29:141–148.
Zamith, V. A., Campos, J. V., and Chizzotti, M. T., 1974, Rothmund’s syndrome: Serum and urine aminogram—Study of a family, Rev. Bras. Pesqui. Med. Biol. 7:23–27.
Zeldis, S. M., Nemerson, Y., Pitlick, F. A., and Lentz, T. L., 1972, Tissue factor (thromboplastin): Localization to plasma membranes by peroxidase-conjugated antibodies, Science 175: 766–768.
Zonana, J., and Rimoin, D. L., 1976, Current concepts in genetics: Inheritance of diabetes mellitus, N. Engl. J. Med. 295:603–605.
Zucker-Franklin, D., Rifkin, H., and Jacobson, H. G., 1968, Werner’s syndrome: An analysis of ten cases, Geriatrics 23:123–135.
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Goldstein, S. (1978). Human Genetic Disorders That Feature Premature Onset and Accelerated Progression of Biological Aging. In: Schneider, E.L. (eds) The Genetics of Aging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2445-4_8
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