Abstract
The pharmacokinetic advantage of intraarterial (i.a.) drug administra-tion was initially articulated by Eckman et al1 and has been subsequently reviewed in several reports.2–6 The theory states that arterial infusion may provide increased drug delivery to the target organ and decreased drug delivery to the systemic circulation when compared with same-dose intravenous (i.v.) administration, and is based on two assumptions: (1) the kinetics of drug distribution in the body can be represented by linear compartmental analysis and (2) the rate coefficients remain constant over the entire range of drug concentrations and for the time periods involved.1
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References
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© 1996 Springer-Verlag Berlin Heidelberg
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Hughes, S.E., Perera, S., Gruber, S.A. (1996). Pharmacokinetic Advantage of Regional Drug Delivery. In: Local Immunosuppression of Organ Transplants. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22105-1_2
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DOI: https://doi.org/10.1007/978-3-662-22105-1_2
Publisher Name: Springer, Berlin, Heidelberg
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