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A critical evaluation of the principles governing the advantages of intra-arterial infusions

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Abstract

From the literature, there appears to be inadequate evidence supporting the clinical use of intraarterial infusions as a method of drug administration. This problem has been evaluated with consideration of the advantages gained in increased total drug delivery and increased drug effectiveness in the region supplied by the infused artery and consideration of the advantage of reduced systemic drug delivery following intraarterial infusion. Carefully chosen simplifying assumptions allow precise determination of the advantages of regional or systemic drug delivery when drug delivery is evaluated by the total time integral of drug concentration. Simplified experimental approaches are suggested for the precise measurement of these advantages. Drug effectiveness is more difficult to evaluate because of the usual nonlinear relationship between effect and concentration. However, certain relationships between the advantage of regional drug delivery and the advantage of regional drug effects are elucidated. This analysis offers new insight into the factors which determine the value of intraarterial drug administration and hopefully will help guide both future experimental studies in this area and clinical application of this method.

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Authors and Affiliations

  1. Membrane Transport Section, Office of the Associate Director for Experimental Therapeutics, Division of Cancer Treatment, National Cancer Institute, National institutes of Health, 20014, Bethesda, Maryland

    Walter W. Eckman & Joseph D. Fenstermacher

  2. Theoretical Statistics and Mathematics Branch, National Institute of Mental Health, National Institutes of Health, 20014, Bethesda, Maryland

    Clifford S. Patlak

Authors
  1. Walter W. Eckman
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  2. Clifford S. Patlak
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  3. Joseph D. Fenstermacher
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Eckman, W.W., Patlak, C.S. & Fenstermacher, J.D. A critical evaluation of the principles governing the advantages of intra-arterial infusions. Journal of Pharmacokinetics and Biopharmaceutics 2, 257–285 (1974). https://doi.org/10.1007/BF01059765

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  • DOI: https://doi.org/10.1007/BF01059765

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