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Biological Functions of EF-Hand Ca2+-Binding Proteins

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Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders

Part of the book series: Neuroscience Intelligence Unit ((NIU.LANDES))

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Abstract

The consensus amino acid sequence for an EF-hand Ca2+-binding domain has allowed identification of more than 200 Ca2+-binding proteins from primary structures, many of them expressed in the central nervous system (Table 2.3). A central question concerns the biological, function of these proteins. Ca2+-binding proteins with known functions, such as calmodulin, troponin C, myosin-light chains, calpain or calcineurin, are far outnumbered by those whose roles are not known. Most of them are expressed in a cell-type specific manner (in contrast to calmodulin, which is ubiquitously distributed). Recently, this family of proteins has attracted a lot of interest since altered concentrations of some of them have been reported in several disease states of the central nervous system and in tumor cells (chapter 6). An exploration of their involvement in mechanisms of calcium-mediated regulation in normal cells should therefore help to elucidate the underlying mechanisms of these pathological conditions.

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  1. University of Zurich, Zurich, Switzerland

    Claus W. Heizmann Ph.D.

  2. Federal Institute for Neurobiology, Magdeburg, Germany

    Katharina Braun Ph.D.

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Heizmann, C.W., Braun, K. (1995). Biological Functions of EF-Hand Ca2+-Binding Proteins. In: Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders. Neuroscience Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21689-7_5

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  • DOI: https://doi.org/10.1007/978-3-662-21689-7_5

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