Skip to main content
SpringerLink
Log in

Therapie mit Granulozyten

  • Chapter
Transfusionsmedizin

  • 51 Accesses

Zusammenfassung

Der Stellenwert der supportiven Therapie mit Granulozyten war in den letzten Jahren umstritten, v a. wegen der kurzen Verweildauer von Granulozyten in den Gefäßen, ihrer Labilität bei und nach der Isolierung aus dem Blut und den Schwierigkeiten, therapeutisch ausreichende Mengen in kurzer Folge von gesunden Blutspendern zu gewinnen. Durch den Einsatz von rekombinanten granulozytenstimulierenden Hormonen bei gesunden Spendern zeichnet sich eine gewisse Renaissance, v a. in der Behandlung von Kindern, ab.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bhatia S, McCullough J, Perry EH, Clay M, Ramsay NKC, Neglia JP (1994) Granulocyte transfusions: efficacy in treating fungal infections in neutropenic patients following bone marrow transplantation. Transfusion 34: 226–232

    Article  PubMed  CAS  Google Scholar 

  2. Cairo MS, Worchester CC, Rucker RW, Hanten S, Amlie RN, Sender L, Hicks DA (1992) Randomized trial of granulocyte transfusions versus intravenous immune globulin therapy for neonatal neutropenia and sepsis. J Pediatr 120: 281–285

    Article  PubMed  CAS  Google Scholar 

  3. Christensen RD, Rothstein G, Anstall HB, Bybee B (1982) Granulocyte transfusions in neonates with bacterial infection, neutropenia, and depletion of mature marrow neutrophils. Pediatrics 70: 1–6

    PubMed  CAS  Google Scholar 

  4. Church JA, Uittenbogaart C (1980) Partial immunologic reconstitution and hyperglobulinemiae in neonatally acquired graft-versus-host disease. Ann Allerg 44: 212–216

    PubMed  CAS  Google Scholar 

  5. Cooper MR (1982) Indications for granulocyte transfusion. In: Vogler WR (ed) Cytapheresis and plasma exchange. Alan Liss, New York, pp 43–59

    Google Scholar 

  6. Creutzig U, Ritter J, Schellong G, for the AML-BFM Study Group (1993) Does cranial irradiation reduce the risk for bone marrow relapse in acute myelogenous leukemia (AML): unexpected results of the childhood AML study BFM-87. J Clin Oncol 11: 279–286

    PubMed  CAS  Google Scholar 

  7. Devine P, Linden JV, Hoffstadter LK, Postoway N, Hines D (1993) Blood donor-, apheresis-, and transfusions-related activities: results of the 1991 american association of blood banks institutional membership questionnaire. Transfusion 33: 779–782

    Article  PubMed  CAS  Google Scholar 

  8. Dutcher JP, Schiffer CA, Johnston GS, Papenburg D, Daly PA, Aisner J, Wiernik PH (1983) Alloimmunization prevents the migration of transfused indium-111-labeled granulocytes to sites of infection. Blood 62: 354–360

    PubMed  CAS  Google Scholar 

  9. Freireich EJ, Morse EE, Bronson W, Carbone PP (1962) Transfusion of granulocytes from donors with chronic myelocytic leukemia to leukopenic recipients. J Clin Invest 41: 1359

    Google Scholar 

  10. Hester JP (1993) Quality assurance in hemapheresis granulocyte transfusions: current need and quality assurance. Transfus Sci 14: 95–99

    Article  Google Scholar 

  11. Huestis DW (1982) Adverse effects of granulocyte donations. In: Vogler WR (ed) Cytapheresis and plasma exchange. Liss, New York, pp 101–114

    Google Scholar 

  12. Huestis DW, Glasser L (1994) The neutrophil in transfusion medicine. Transfusion 34: 630–646

    Article  PubMed  CAS  Google Scholar 

  13. Joyce RA, Boggs DR, Chervenick PA, Lalezari P (1980) Neutrophil kinetics in Felty’s syndrome. Am J Med 69: 695–702

    Article  PubMed  CAS  Google Scholar 

  14. Karp DD, Ervin TJ, Tuttle S, Gorgone BC, Lavin P, Yunis EJ (1982) Pulmonary complications during granulocyte transfusion: incidence and clinical features. Vox Sang 42: 57–61

    Article  PubMed  CAS  Google Scholar 

  15. Lee GR, Bithell TC, Foerster J, Athens JW, Lukens JN (1993) Wintrobe’s clinical hematology, 9th edn. Lea & Febiger, Philadelphia London

    Google Scholar 

  16. McCullough J, Weiblen BJ, Clay ME, Forstrom L (1981) Effect of leukocyte antibodies on the fate in vivo of indium-111-labeled granulocytes. Blood 58: 164–170

    PubMed  CAS  Google Scholar 

  17. Mollison PL, Engelfriet CP, Contreras M (1993) Blood transfusion in clinical medicine. Blackwell, London Edinburgh Boston

    Google Scholar 

  18. Neppert J, Busch H (1979) Niedrige Leukozytenzahl bei Blutspendern. Münchener Med Wochenschr 121: 1573–1574

    CAS  Google Scholar 

  19. Neppert J (1983) Die Granulozytentransfusion. Dtsch Med Wochenschr 108: 3–5

    Article  PubMed  CAS  Google Scholar 

  20. Nusbacher J (1979) A comparison of technics for leukapheresis and plateletpheresis. In: Nusbacher J, Berkman EM (eds) Fundamentals of a pheresis program. Am Assoc Blood Banks, Washington, pp 49–61

    Google Scholar 

  21. Popovsky MA, Abel MD, Moore SB (1983) Transfusion-related acute lung injury associated with passive transfer of anti-leukocyte antibodies. Am Rev Respir Dis 128: 185–189

    PubMed  CAS  Google Scholar 

  22. Price TH (1983) Neutrophil transfusion. Transfusion 23: 504–507

    Article  PubMed  CAS  Google Scholar 

  23. Robinson WA, Mangalik A (1975) The kinetics and regulation of granulopoiesis. Sem Hematol 12: 7–21

    CAS  Google Scholar 

  24. Rohrer C, Ami U, Deubelbeiss KA (1983) Influence of the spleen on the distribution of blood neutrophils. Scand J Haematol 30: 103–109

    Article  PubMed  CAS  Google Scholar 

  25. Saverymuttu SH, Peters AM, Keshavarzian A, Reavy HJ, Lavender JP (1985) The kinetics of 111Indium distribution following injection of 111 Indium labelled autologous granulocytes in man. Br J Haematol 61: 675–685

    Article  PubMed  CAS  Google Scholar 

  26. Storb R, Weiden PL (1981) Transfusion problems associated with transplantation. Sem Hematol 18: 163–176

    CAS  Google Scholar 

  27. Strauss RG, Connett JE, Gale RP, Bloomfield CD, Herzig GP, McCullough J, Maguire LC, Winston DJ, Ho W, Stump DC, Miller WV, Koepke JA (1981) A controlled trial of prophylactic granulocyte transfusions during initial induction chemotherapy for acute myelogenous leukemia. N Engl J Med 305: 597–603

    Article  PubMed  CAS  Google Scholar 

  28. Vallejos C, McCredie KB, Bodey GP, Hester JP, Freireich EJ (1975) White blood cell transfusions for control of infections in neutropenic patients. Transfusion 15: 28–33

    Article  PubMed  CAS  Google Scholar 

  29. Vincent PC (1977) The measurement of grnulocyte kinetics. Br J Haematol 36: 1–4

    Article  PubMed  CAS  Google Scholar 

  30. Walker RW (1993) Technical manual of the American Asso- ciation of Blood Banks, 11th ed. Karger, Basel, pp 408–409

    Google Scholar 

  31. Williams WJ, Beutler E, Erslev AJ (199o) Hematology, 4th edn. Blackwell, McGraw-Hill, New York

    Google Scholar 

  32. Yamtovian R, Abramson J, Quie P, McCullough J (1981) Granulocyte transfusion therapy in chronic granulomatous disease. Report of a patient and review of the literature. Transfusion 21: 739–743

    Article  Google Scholar 

  33. Young LS (1983) The role of granulocyte transfusions in treating and preventing infection. Cancer Treat Rep 67: 109–111

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. J. Neppert
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Klinische Immunologie und Transfusionsmedizin der Universität, Langhansstr. 7, D-35385, Gießen, Deutschland

    Christian Mueller-Eckhardt

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Neppert, J. (1996). Therapie mit Granulozyten. In: Mueller-Eckhardt, C. (eds) Transfusionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10599-3_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-10599-3_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10600-6

  • Online ISBN: 978-3-662-10599-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation