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The Role of Chemokines in Inflammatory Skin Diseases

  • Conference paper
Leucocyte Trafficking

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 44))

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Abstract

The skin provides a major boundary between the host and the external environment, and it is obviously very well equipped to mount effective immune responses against microorganisms. Dendritic cells (DCs), including epidermal Langerhans cells and dermal DCs, specialize in recognizing and capturing foreign antigens as well as in the activation of naive T cells, and are thus essential for the induction of immune responses. T lymphocytes transduce antigen recognition into effector mechanisms to eliminate pathogens. The recruitment of T cells and other leukocytes at the site of skin inflammation is therefore a critical step for an efficient engagement of potentially dangerous signals (Koelle et al. 2002). The outcome of T cell-dependent skin reactions also depends on the cross-talk between infiltrating T cells and resident skin populations. Keratinocytes, mast cells, and endothelial cells, which constitute the static component of the skin immune system, as well as DCs contribute to attract discrete T cell subsets in the skin. In turn, activated T cells secrete cytokines and express molecules which activate resident cells, leading to amplification of the inflammatory reaction.

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Authors
  1. G. Girolomoni
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  2. S. Pastore
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  3. A. Cavani
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  4. C. Albanesi
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Editors and Affiliations

  1. Experimental Rheumatology, Medical Clinic, University Hospital Charité, Schumannstr. 21/22, 10117, Berlin, Germany

    Alf Hamann

  2. Corporate Research Business, Area Dermatology, Schering AG, 13342, Berlin, Germany

    Khusru Asadullah  & Arndt Schottelius  & 

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Girolomoni, G., Pastore, S., Cavani, A., Albanesi, C. (2004). The Role of Chemokines in Inflammatory Skin Diseases. In: Hamann, A., Asadullah, K., Schottelius, A. (eds) Leucocyte Trafficking. Ernst Schering Research Foundation Workshop, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05397-3_11

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  • DOI: https://doi.org/10.1007/978-3-662-05397-3_11

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