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The Human Renin-Angiotensin System in Transgenic Rats — New Tools for Antihypertensive Therapy

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Transgenic Animals as Model Systems for Human Diseases

Part of the book series: Schering Foundation Workshop ((SCHERING FOUND,volume 6))

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Abstract

The renin—angiotensin system (RAS) is one of the best studied regulatory systems involved in control of cardiovascular function and volume homeostasis. Its effector peptide angiotensin II exerts a multiplicity of functions by raising peripheral resistance through vasoconstriction, enhancing renal sodium reabsorption, facilitation of catecholamine release from sympathetic nerve endings or stimulation of mineralcorticoid production in the adrenal gland (Table 1) [1,2].

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Authors
  1. Jürgen Wagner
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  2. Martin Paul
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  3. Detlev Ganten
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Editors and Affiliations

  1. Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030, Vienna, Austria

    Erwin F. Wagner

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© 1993 Springer-Verlag Berlin Heidelberg

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Wagner, J., Paul, M., Ganten, D. (1993). The Human Renin-Angiotensin System in Transgenic Rats — New Tools for Antihypertensive Therapy. In: Wagner, E.F., Theuring, F. (eds) Transgenic Animals as Model Systems for Human Diseases. Schering Foundation Workshop, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02925-1_1

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  • DOI: https://doi.org/10.1007/978-3-662-02925-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02927-5

  • Online ISBN: 978-3-662-02925-1

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