Other Toxic and Metabolic Leukoencephalopathies

  • Jacob Valk
  • Marjo S. van der Knaap


Myelin is unique among membranes because of its consisting predominantly of lipid and because of its long half-life. As a consequence, myelin accumulates lipophilic substances and is exposed to their adverse effects over a long period of time. As one might expect, there are various substances which cause degradation of the myelin membrane and demyelination; these are called myelinotoxic.


White Matter Fetal Alcohol Syndrome Myelin Membrane Myelin Loss Lead Intoxication 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Jacob Valk
    • 1
  • Marjo S. van der Knaap
    • 2
  1. 1.Department of Diagnostic Radiology and NeuroradiologyFree University HospitalAmsterdamThe Netherlands
  2. 2.Department of Child NeurologyAcademic HospitalUtrechtThe Netherlands

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