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Therapeutic decisions in mild hypertension: an introductory overview

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Mild hypertension
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Abstract

This introductory overview of mild hypertension will deal with the related issues of whom to treat and how to treat. Intervention trials have not so far given clear guidelines for the effective treatment of mild hypertension. Perhaps these studies have been flawed by the nature of their design; they have tried to achieve the combined goal of statistical validity and wide applicability in diverse groups of hypertensive patients. Moreover, the risk factor concept involves a statement of group probability so that some patients at low risk develop cardiovascular complications and others at high risk do not.

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References

  1. Alderman MH, Madhavan MS (1981) Management of the hypertensive patient: a continuing dilemma. Hypertension 3:192–197.

    PubMed  CAS  Google Scholar 

  2. Anderson RJ, Hart GH, Crumpler CP, Reed WG, Matthews CA (1981) Oral Clonidine loading in hypertensive urgencies. JAMA 246:848–850.

    Article  PubMed  CAS  Google Scholar 

  3. Bravo EL, Tarazi RC, Fouad FM, Vidt DG, Gifford RW (1981) Clonidine-suppression test, a useful aid in the diagnosis of pheochromocytoma. N Engl J Med 305:623–626.

    Article  PubMed  CAS  Google Scholar 

  4. Campese VM, Romoff M, Telfer N, Weidman P, Massry SG (1980) Role of sympathetic nerve inhibition and body sodium-volume state in the antihypertensive action of Clonidine in essential hypertension. Kidney Int 18:351–357.

    Article  PubMed  CAS  Google Scholar 

  5. Davis DS, Wing LMH, Reid JL, Neill E, Tippett P, Dollery CT (1977) Pharmacokinetics and concentration-effect relationships of intravenous and oral Clonidine. Clin Pharmacol Ther 21:593–601.

    Google Scholar 

  6. Devereux RB, Pickering TG, Harshfielf GA (1983) Left ventricular hypertrophy in patients with hypertension: importance of blood pressure response to regularly recurring stress. Circulation 68:470–476.

    Article  PubMed  CAS  Google Scholar 

  7. Dollery CT (1981) Does it matter how blood pressure is reduced? Clin Sci 61:413s–420s.

    PubMed  Google Scholar 

  8. Ebringer A, Dolye AE, Dawborn JK, Johnston CI, Mashford ML (1970) The use of Clonidine in the treatment of hypertension. Med J Aust 1:523–530.

    Google Scholar 

  9. Freis ED (1982) Should mild hypertension be treated? N Engl J Med 307:306–309.

    Article  PubMed  CAS  Google Scholar 

  10. Guyton AC, Cowley Jr AW, Coleman TG et al. (1974) Hypertension: a disease of abnormal circulatory control. Chest 65:328–338.

    PubMed  CAS  Google Scholar 

  11. Helgeland A (1980) Treatment of mild hypertension: a five-year controlled study. Am J Med 69:725–732.

    Article  PubMed  CAS  Google Scholar 

  12. Hypertension Detection and Follow-up Program Cooperative Study (1979 a) Five-year findings of the hypertension detection and follow-up program. Reduction of mortality in persons with high blood pressure including mild hypertension. JAMA 242:2562–2571.

    Article  Google Scholar 

  13. Hypertension Detection and Follow-up Program Cooperative Study (1979 b) Five-year findings of the hypertension detection and follow-up program, II. Mortality by race — sex and age. JAMA 242:2572–2577.

    Article  Google Scholar 

  14. Hypertension Detection and Follow-up Program Cooperative Study (1982) The effects of treatment on mortality in ‘mild’ hypertension. N Engl J Med 307:976–980.

    Article  Google Scholar 

  15. Itskovitz D (1980) Renal effects of Clonidine. J Cardiovasc Pharmacol 2 (Suppl 1):S47–S60.

    Article  PubMed  Google Scholar 

  16. Laird WP, Fixier DE (1981) Left-ventricular hypertrophy in adolescents with elevated blood pressure: assessment by chest roentgenography, electrocardiography, and echocardiography. Pediatrics 67:255–259.

    PubMed  CAS  Google Scholar 

  17. Laubie M, Schmitt H (1974) Influence of autonomic blockade on the reduction in myocardial performance produced by Clonidine. Eur J Pharmacol 25:56–60.

    Article  PubMed  CAS  Google Scholar 

  18. Mancia G, Ferrari A, Gregorini A, Zanchetti A (1979) Clonidine and carotid baroreflex in essential hypertension. Hypertension 1:362–370.

    PubMed  CAS  Google Scholar 

  19. Miller M (1980) Clonidine-induced diuresis in the rat: evidence for a renal site of action. J Pharmacol Exp Ther 214:608–613.

    PubMed  CAS  Google Scholar 

  20. Multiple Risk Factor Intervention Trial Research Group (1982) Multiple Risk factor intervention trial. JAMA 248:1465–1477.

    Article  Google Scholar 

  21. MacGregor GA, Markandu ND, Best FE et al. (1982) Double-blind randomised crossover trial of moderate sodium restriction in essential hypertension. Lancet i: 351–354.

    Google Scholar 

  22. Peart WS (1981) The problem of treatment in mild hypertension. Clin Sci 61:403s–411s.

    PubMed  Google Scholar 

  23. Perloff D, Sokolow M, Cowan R (1983) The prognostic value of ambulatory blood pressures. JAMA 249:2792–2798.

    Article  PubMed  CAS  Google Scholar 

  24. Polk B (1982) Effect of antihypertensive medication of left-ventricular hypertrophy. Am J Epidemiol 116:579.

    Google Scholar 

  25. Reisin E, Abel R, Modan M, Silverberg DS, Eliahou HE, Modan B (1978) Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. N Engl J Med 298:1–60.

    Article  PubMed  CAS  Google Scholar 

  26. Savage DD, Drayer JIM, Henry WL et al. (1979) Echocardiographic assessment of cardiac anatomy and function in hypertensive subjects. Circulation 59:623–632.

    PubMed  CAS  Google Scholar 

  27. Shapiro AP (1980) Behaviour modification: can it control hypertension? J Cardiovasc Med 12:1075–1079.

    Google Scholar 

  28. Society of Actuaries and Association of Life Insurance Medical Directors of America (1980) Build and Blood Pressure Study 1979. Recording and Statistical Corp, USA.

    Google Scholar 

  29. Strunkard AJ (1980) Obesity and social environment: current status, future prospects. In: Bray GA (ed) Obesity in America: a conference. NIH Publication No. 80–359, May.

    Google Scholar 

  30. The Australian Therapeutic Trial in Mild Hypertension (1980) Lancet i: 1261–1267.

    Google Scholar 

  31. Smith WF (1977) Treatment of Mild Hypertension: results of a ten-year intervention trial. Circ Res 40 (Suppl 1):98–105.

    Google Scholar 

  32. Veterans Administration Cooperative Study Group of Antihypertensive Agents (1970) Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA 213:1143–1152.

    Article  Google Scholar 

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© 1984 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Franklin, S.S. (1984). Therapeutic decisions in mild hypertension: an introductory overview. In: Weber, M.A., Mathias, C.J. (eds) Mild hypertension. Steinkopff. https://doi.org/10.1007/978-3-642-87506-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-87506-9_7

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0647-3

  • Online ISBN: 978-3-642-87506-9

  • eBook Packages: Springer Book Archive

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