Das Glaukom pp 34-58 | Cite as

Die Bedeutung vaskulärer Faktoren in der Pathogenese des Glaukomschadens

  • S. S. Hayreh
Conference paper

Zusammenfassung

Visusverluste beim Glaukom und damit verbundene Erkrankungen sind im wesentlichen auf eine Schädigung des Sehnervenkopfs (SNK) zurückzuführen. Der Mechanismus der glaukomatösen Schädigung des Sehnervenkopfs bleibt trotz umfangreicher Untersuchungen zu diesem Thema seit Entdeckung der glaukomatösen Papillenexkavation vor fast 150 Jahren rätselhaft und ist stark umstritten. Ich habe mich mit diesem Thema vor einiger Zeit erneut auseinandergesetzt [67].

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Literatur

  1. 1.
    Alderman MH, Ooi WL, Madhavan S, Cohen H (1988) Treatment-induced blood pressure reduction and the risk of myocardial infarction. JAMA 262:920–924CrossRefGoogle Scholar
  2. 2.
    Alm A, Bill A (1973) Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labeled microspheres including flow determinations in brain and some other tissues. Exp Eye Res 15:15–29PubMedCrossRefGoogle Scholar
  3. 3.
    Anderson DR (1989) Glaucoma: the damage caused by pressure. Am J Ophthalmol 108:485–495PubMedGoogle Scholar
  4. 4.
    Armaly MF (1980) Lessons to be learned from the collaborative glaucoma study. Surv Ophthalmol 25:139–144PubMedCrossRefGoogle Scholar
  5. 5.
    Armaly MF, Krueger DE, Maunder L, Becker B et al. (1980) Biostatistical analysis of the collaborative glaucoma study. I. Summary report of the risk factor for glaucomatous visual-field defects. Arch Ophthalmol 98:2163–2171PubMedCrossRefGoogle Scholar
  6. 6.
    Bailliart P (1928) La pression arterielle retinienne. Ann Oculist (Paris) 165:321–348Google Scholar
  7. 7.
    Bailliart P (1929) Les relations entre la pression arterielle et la tension oculaire. Bull Soc Ophthalmol Fr 29:712–716Google Scholar
  8. 8.
    Bailliart P (1933) Considerations cliniques sur l’excavation atrophique du nerf optique sans hypertension oculaire. Bull Soc Ophthalmol Fr 46:407–409Google Scholar
  9. 9.
    Best F (1931) In: Schieck F, Bruckner A (Hrsg) Kurzes Handbuch der Ophthalmologie, Bd 6. Springer, Berlin, S. 545–546Google Scholar
  10. 10.
    Bill A (1974) Effects of acetazolamide and carotid occlusion on the ocular blood flow in unanesthetized rabbits. Invest Ophthalmol 13:954–958PubMedGoogle Scholar
  11. 11.
    Bill A (1985) Some aspects of the ocular circulation. Invest Ophthalmol Vis Sci 26:410–424PubMedGoogle Scholar
  12. 12.
    Bill A, Heilmann K (1975) Ocular effects of clonidine in cats and monkeys (Macaca irus). Exp Eye Res 21:481–488PubMedCrossRefGoogle Scholar
  13. 13.
    Bill A, Linder J (1976) Sympathetic control of cerebral blood flow in acute arterial hypertension. Acta Physiol Scand 96:114–121PubMedCrossRefGoogle Scholar
  14. 14.
    Bill A, Sperber GO (1987) Blood flow and glucose consumption in the optic nerve: Effects of high intraocular pressure. In: Krieglstein GK (ed) Glaucoma update III. Springer, Berlin Heidelberg New York, pp 51–57CrossRefGoogle Scholar
  15. 15.
    Boisvert DJP, Jones JV, Harper AM (1977) Cerebral blood flow autoregulation to acutely increasing blood pressure during sympathetic stimulation. Acta Neurol Scand 56(Suppl 64): 46–47Google Scholar
  16. 16.
    Carter CJ, Brooks DE, Doyle DL, Drance SM (1990) Investigations into a vascular etiology for low-tension glaucoma. Ophthalmology 97:49–55PubMedGoogle Scholar
  17. 17.
    Chumbley LC, Brubaker RF (1976) Low-tension glaucoma. Am J Ophthalmol 81:761–767PubMedGoogle Scholar
  18. 18.
    Connor RCR (1962) Complicated migraine: a study of permanent neurological and visual defects caused by migraine. Lancet II: 1072–1075CrossRefGoogle Scholar
  19. 19.
    Cove DH, Seddon M, Fletcher FR, Dukes DC (1979) Blindness after treatment for malignant hypertension. Br Med J 2:245–246PubMedCrossRefGoogle Scholar
  20. 20.
    Dandona L, Quigley HA, Brown AE, Enger C (1990) Quantitative regional structure of the normal human lamina cribrosa A racial comparison. Arch Ophthalmol 108: 393–398PubMedCrossRefGoogle Scholar
  21. 21.
    Demailly P, Cambien F, Plouin PF, Baron P et al. (1984) Do patients with low tension glaucoma have particular cardiovascular characteristics? Ophthalmologica 188:65–75PubMedCrossRefGoogle Scholar
  22. 22.
    Dobree JH (1956) Calibre changes in retinal vessels occurring in raised ocular tension. Circulatory compensation in chronic glaucoma. Br J Ophthalmol 40:1–13PubMedCrossRefGoogle Scholar
  23. 23.
    Dorfman LJ, Marshall WH, Deiter ER (1979) Cerebral infarction and migraine: clinical and radiological correlations. Neurology 29:317–322PubMedGoogle Scholar
  24. 24.
    Drance SM (1962) Studies in the susceptibility of the eye to raised intraocular pressure. Arch Ophthalmol 68:478–485PubMedCrossRefGoogle Scholar
  25. 25.
    Drance SM (1972) Some factors in the production of low tension glaucoma. Br J Ophthalmol 56:229–242PubMedCrossRefGoogle Scholar
  26. 26.
    Drance SM (1972) Some factors involved in the production of low tension glaucoma. In: The optic nerve, Kimpton, London, pp 339–366Google Scholar
  27. 27.
    Drance SM, Wheeler C, Pattullo M (1968) Uniocular open-angle glaucoma. Am J Ophthalmol 65:891–902PubMedGoogle Scholar
  28. 28.
    Drance SM, Morgan RW, Sweeney VP (1973) Shock-induced optic neuropathy. A cause of nonprogressive glaucoma. N Engl J Med 288:392–395PubMedCrossRefGoogle Scholar
  29. 29.
    Drance SM, Sweeney VP, Morgan R, Feldman F (1973) Studies of factors involved in the production of low tension glaucoma. Arch Ophthalmol 89:457–465PubMedCrossRefGoogle Scholar
  30. 30.
    Drance SM, Schulzer M, Douglas GR, Sweeney VP (1978) Use of discriminant analysis. II. Identification of persons with glaucomatous visual field defects. Arch Ophthalmol 96:1571–1573PubMedCrossRefGoogle Scholar
  31. 31.
    Drance SM, Douglas GR, Wijsman K, Chulzer M, Britton RJ (1988) Response of blood flow to warm and cold in normal and low-tension glaucoma patients. Am J Ophthalmol 105:35–39PubMedGoogle Scholar
  32. 32.
    Duke-Elder S (1953) Primary glaucoma as a vascular disease. Ulster Med J 22:1–16Google Scholar
  33. 33.
    Dukes HT, Vieth HG (1964) Cerebral arteriography during migraine prodrome and headache. Neurology 14:636–639PubMedGoogle Scholar
  34. 34.
    Edmeads J (1977) Cerebral blood flow in migraine. Headache 17:148–152PubMedCrossRefGoogle Scholar
  35. 35.
    Edvinsson L, Owman C, Siesjo B (1976) Physiological role of cerebrovascular sympathetic nerves in the autoregulation of cerebral blood flow. Brain Res 117:519–523PubMedCrossRefGoogle Scholar
  36. 36.
    Ekbom KA (1973) Scotoma due to arterial hypotension. Acta Ophthalmol 51:375–382Google Scholar
  37. 37.
    Elwyn H (1940) Calcified carotid artery with atrophy of the optic nerve, cupping, and low tension. Arch Ophthalmol 24:476–478CrossRefGoogle Scholar
  38. 38.
    Ernest JT (1974) Autoregulation of optic-disk oxygen tension. Invest Ophthalmol Vis Sci 13:101–106Google Scholar
  39. 39.
    Ernest JT (1976) Optic disc blood flow. Trans Ophthalmol Soc UK 96:348–351PubMedGoogle Scholar
  40. 40.
    Ernest JT (1977) Optic disk oxygen tension. Exp Eye Res 24:271–278PubMedCrossRefGoogle Scholar
  41. 41.
    Ernest JT (1979) Autoregulation of blood flow in the distal segment of the optic nerve. In: Krieglstein GK, Leydhecker W (eds) Glaucoma update, Springer, Berlin Heidelberg New York, pp 93–100CrossRefGoogle Scholar
  42. 42.
    Fitch W, MacKenzie ET, Harper AM (1975) Effects of decreasing arterial blood presure on cerebral blood flow in the baboon; influence of the sympathetic nervous system. Circ Res 37:550–557PubMedGoogle Scholar
  43. 43.
    Floras JS (1988) Antihypertensive treatment, myocardial infraction, and nocturnal myocardial ischaemia. Lancet II: 994–996CrossRefGoogle Scholar
  44. 44.
    Floras J, Sleight P (1983) Ambulatory monitoring of blood pressure. In: Sleight P, Jones JV (eds) Scientific foundations of cardiology. Heinemann, London, pp 155–164Google Scholar
  45. 45.
    Floras JS, Jones JV, Hassan MO et al. (1981) Cuff and ambulatory blood pressure in subjects with essential hypertension. Lancet II: 107–109CrossRefGoogle Scholar
  46. 46.
    Francois J (1972) The glaucomatous optic disk. Isr J Med Sci 8:1373–1381PubMedGoogle Scholar
  47. 47.
    Francois J, Neetens A (1970) The deterioration of the visual field in glaucoma and the blood pressure. Doc Ophthalmol 28:70–132PubMedCrossRefGoogle Scholar
  48. 48.
    Gafner F, Goldmann H (1955) Experimentelle Untersuchungen über den Zusammenhang von Augendrucksteigerung und Gesichtsfeldschädigung. Ophthalmologica (Basel) 130:357–377CrossRefGoogle Scholar
  49. 49.
    Gallois J (1933) Glaucome chronique et abaissement de la tension artérielle générale. Bull Soc Ophthalmol Fr (Feb): 110–112Google Scholar
  50. 50.
    Gasser P, Flammer J (1987) Influence of vasospasm on visual function. Doc Ophthalmol 66:3–18PubMedCrossRefGoogle Scholar
  51. 51.
    Gasser P, Flammer J, Guthauser U, Niesel P (1986) Bedeutung des vasospastischen Syndroms in der Augenheilkunde. Klin Monatsbl Augenheilkd 188:398–399CrossRefGoogle Scholar
  52. 52.
    Gasteiger H (1936) Über den Wert der Röntgendiagnose bei unklaren Sehnervenleiden. Klin Monatsbl Augenheilkd 96:589–601Google Scholar
  53. 53.
    Geijer C, Bill A (1979) Effects of raised intraocular pressure on retinal, prelaminar, laminar, and retrolaminar optic nerve blood flow in monkeys. Invest Ophthalmol Vis Sci 18:1030–1042PubMedGoogle Scholar
  54. 54.
    Geijssen HC, Greve EL (1987) Vascular risk factors in progressive low tenison glaucoma. In: Krieglstein GK (ed) Glaucoma update III. Springer, Berlin Heidelberg New York, pp 77–83CrossRefGoogle Scholar
  55. 55.
    Ghislanzoni R, Ramella G (1959) Gli elementi radiologici nella diagnosi di sclerosi dei vasi della base cerebrale in rapporto sopratutto colic alterazioni del nerve ottico. Minerva Med 50:1546–1549PubMedGoogle Scholar
  56. 56.
    Goldberg I, Hollow FC, Kass MA, Becker B (1981) Systemic factors in patients with low-tension glaucoma. Br j Ophthalmol 65:56–62PubMedCrossRefGoogle Scholar
  57. 57.
    Gramer E, Leydhecker W (1985) Glaucom ohne Hochdruck: eine klinische Studie. Klin Monatsbl Augenheilkd 186:262–267PubMedCrossRefGoogle Scholar
  58. 58.
    Graveson GS (1949) Retinal arterial occlusion in migraine. Br Med J 2:838–840PubMedCrossRefGoogle Scholar
  59. 59.
    Grunwald JE, Riva CE, Stone RA, Keates EU et al. (1984) Retinal autoregulation in open-angle glaucoma. Ophthalmology 91:1690–1694PubMedGoogle Scholar
  60. 60.
    Guthauser U, Flammer J, Mahler F (1988) The relationship between digital and ocular vasospasm. Graefe’s Arch Clin Exp Ophthalmol 226:224–226CrossRefGoogle Scholar
  61. 61.
    Haas JS (1962) Low tension glaucoma. Trans Pac Coast Otoophthalmol Soc 43:153–160Google Scholar
  62. 62.
    Harrington DO (1959) The pathogenesis of the glaucoma field. Am J Ophthalmol 47:177–185PubMedGoogle Scholar
  63. 63.
    Harrington DO (1960) Pathogenesis of the glaucomatous field defects: individual variations in pressure sensitivity. In: Glaucoma, Trans 5th Conf Josiah Macy Jr Found, New YorkGoogle Scholar
  64. 64.
    Hayreh SS (1972) Optic disc changes in glaucoma. Br J Ophthalmol 56:175–185PubMedCrossRefGoogle Scholar
  65. 65.
    Hayreh SS (1974) Pathogenesis of cupping of the optic disc. Br J Ophthalmol 58:863–876PubMedCrossRefGoogle Scholar
  66. 66.
    Hayreh SS (1976) The pathogenesis of optic nerve lesions in glaucoma. Trans Am Acad Ophthalmol Otolaryngol 81:OP-197–213Google Scholar
  67. 67.
    Hayreh SS (1978) Pathogenesis of optic nerve damage and visual field defects. In: Heilmann K, Richardson KT (eds) Glaucoma: conceptions of a disease. Thieme, Stuttgart, pp 104–137Google Scholar
  68. 68.
    Hayreh SS (1985) Inter-individual variation in blood supply of the optic nerve head. Its importance in various ischemic disorders of the optic nerve head, and glaucoma, low-tension glaucoma and allied disorders. Doc Ophthalmol 59:217–246PubMedCrossRefGoogle Scholar
  69. 69.
    Hayreh SS (1987) Anterior ischemic optic neuropathy. VIII. Clinical features and pathogenesis of post-hemorrhagic amaurosis. Ophthalmology 94:1488–1502PubMedGoogle Scholar
  70. 70.
    Hayreh SS (1987) Factors determining the glaucomatous optic nerve damage. In: Krieglstein GK (ed) Glaucoma update III. Springer, Berlin Heidelberg New York, pp 40–46CrossRefGoogle Scholar
  71. 71.
    Hayreh SS (1989) Blood supply of the optic nerve head in health and disease. In: Lambrou GN, Greve EL (eds) Ocular blood flow in glaucoma: means, methods and measurements. Kugler & Ghedini, Amstelveen, pp 3–54Google Scholar
  72. 72.
    Hayreh SS (1990) In vivo chorodial circulation and its watershed zones. Eye 4:273–289PubMedCrossRefGoogle Scholar
  73. 73.
    Hayreh SS (in press) Blood supply of the optic nerve head. Fortschr OphthalmolGoogle Scholar
  74. 74.
    Hayreh SS, Vrabe F (1966) Am J Ophthalmol 61:136–150PubMedGoogle Scholar
  75. 75.
    Hayreh SS, Revie IHS, Edwards J (1970) Vasogenic origin of visual field defects and optic nerve changes in glaucoma. Br J Ophthalmol 54:461–472PubMedCrossRefGoogle Scholar
  76. 76.
    Hayreh SS, March W, Anderson DR (1979) Pathogenesis of block of rapid orthograde axonal transport by elevated intraocular pressure. Exp Eye Res 28:515–523PubMedCrossRefGoogle Scholar
  77. 77.
    Hayreh SS, Servais GE, Virdi PS (1986) Fundus lesions in malignant hypertension. V. Hyperensive optic neuropathy. Ophthalmology 93:74–87PubMedGoogle Scholar
  78. 78.
    Heilmann K (1972) Augendruck, Blutdruck und Glaukomschaden. Enke, StuttgartGoogle Scholar
  79. 79.
    Heilmann K (1974) Clonidin in der Augenheilkunde. Enke, StuttgartGoogle Scholar
  80. 80.
    Hulse JA, Taylor DSI, Dillion MJ (1979) Blindness and paraplegia in severe childhood hypertension. Lancet II:553–556CrossRefGoogle Scholar
  81. 81.
    Jaeger AE, Weeks SD, Duane TD (1964) Perimetric and visual acuity changes during ophthalmodynamometry. Arch Ophthalmol 71:484–488PubMedCrossRefGoogle Scholar
  82. 82.
    Johnson DG, Drance SM (1968) Some studies on the circulation in patients with advanced open angle glaucoma. Can J Ophthalmol 3:149–153PubMedGoogle Scholar
  83. 83.
    Joist JH, Lichtenfeld P, Mandell AI, Kolker AE (1976) Platelet function, blood coagulability, and fibrinolysis in patients with low tension glaucoma. Arch Ophthalmol 94:1893–1895PubMedCrossRefGoogle Scholar
  84. 84.
    Jones JV, Fitch W, MacKenzie ET et al. (1976) Lower limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circ Res 39:555–557PubMedGoogle Scholar
  85. 85.
    Kishi S, Tso MOM, Hayreh SS (1985) Fundus lesions in malignant hypertension. II. A pathological study of experimental hypertensive optic neuropathy. Arch Ophthalmol 103:1198–1206PubMedCrossRefGoogle Scholar
  86. 86.
    Kitazawa Y, Shirai H, Go JF (1989) The effect of Ca2⊥-antagonist on visual field in low-tension glaucoma. Graefe’s Arch Clin Exp Ophthalmol 227:408–412CrossRefGoogle Scholar
  87. 87.
    Kleiman N, Goodman D, Schechtman K, Robert R (1988) Diltiazem reinfarction study. Lack of diurnal variation in the occurrence of non-Q-wave myocardial infarcton: results of a prospective tusy. J Am Coll Cardiol 11:27ACrossRefGoogle Scholar
  88. 88.
    Knapp A (1932) Association of sclerosis of the cerebral basal vessels with optic atrophy and cupping: report of 10 cases. Arch Ophthalmol 8:637–648CrossRefGoogle Scholar
  89. 89.
    Knapp A (1940) Course in certain cases of atrophy of the optic nerve with dupping and low tension. Arch Ophthalmol 23:41–47CrossRefGoogle Scholar
  90. 90.
    Kolker AE, Jois JH, Mandell AI, Becker B (1976) Platelet function, blood coagulability, and fibrinolysis in patients with low tension glaucoma. In: Abstr ARVO Meet, Sarasota, FlaGoogle Scholar
  91. 91.
    Laatikainen L (1971) Fluorescein angiographic studies of the peripapillary and perilimbal regions in simple, capsular and low-tension glaucoma. Acta Ophthalmol (Suppl 111): 9–83Google Scholar
  92. 92.
    Langham ME (1987) Ocular blood flow and visual loss in glaucomatous eyes. In: Krieglstein GK (ed) Glaucoma update III. Springer, Berlin Heidelberg New York, pp 58–66CrossRefGoogle Scholar
  93. 93.
    Langham ME, To’mey KF, Preziosi TJ (1981) Carotid occlusive disease: effect of complete occlusion of internal carotid artery on introacular pulse/pressure relation and on ophthalmic arterial pressure. Stroke 12:759–765PubMedCrossRefGoogle Scholar
  94. 94.
    Lauber H (1936) Treatment of atrophy of the optic nerve. Arch Ophthalmol 16:555–568CrossRefGoogle Scholar
  95. 95.
    Lauritzen M, Olsen TS, Paulson OB (1982) Regional cerebral blood flow in classic migraine: a possible relationship to the spreading depression of Leao? In: Rose FC (ed) Advances in migraine research and therapy. Raven, New York, pp 105–115Google Scholar
  96. 96.
    Lauritzen M, Olsen TS, Larsen NA, Paulson OB (1983) Changes in the regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol 13:633–641PubMedCrossRefGoogle Scholar
  97. 97.
    Leighton DA, Phillips CI (1972) Systemic blood pressure in open-angle glaucoma, low-tenison glaucoma, and the normal eye. Br J Ophthalmol 56:447–453PubMedCrossRefGoogle Scholar
  98. 98.
    Leske MC (1983) The epidemiology of open-angle glaucoma: a review. Am J Epidemiol 118:166–191PubMedGoogle Scholar
  99. 99.
    Leske MC, Podgor MJ (1983) Intraocular pressure, cardiovascular risk variables, and visual field defects. Am J Epidemiol 118:280–287PubMedGoogle Scholar
  100. 100.
    Levene RZ (1980) Low-tension glaucoma: a critical review and new material. Surv Ophthalmol 24:621–664PubMedCrossRefGoogle Scholar
  101. 101.
    Lobstein A, Herr FJ (1966) L’ophtalmodynamomètre dans le glaucome. Ann Oculist (Paris) 199:38–69Google Scholar
  102. 102.
    Loebl M, Schwartz B (1977) Fluorescein angiographic defect of the optic disc in ocular hypertension. Arch Ophthalmol 95:1980–1984PubMedCrossRefGoogle Scholar
  103. 103.
    MacKenzie ET, McGerorge AP, Graham DI et al. (1977) Breakthrough of cerebral autoregulaton and the sympathetic nervous system. Acta Neurol Scan (Suppl 64): 56:48–49Google Scholar
  104. 104.
    Magiot A (1938) Glaucomes sans hypertension. Ann Oculist (Paris) 175:349–368Google Scholar
  105. 105.
    Magnus JA (1947) A case of pseudo-glaucoma. Br J Ophthalmol 31:692–696CrossRefGoogle Scholar
  106. 106.
    McDonald WI, Sanders MD (1971) Migraine complicated by ischaemic papillopathy. Lancet II:521–523CrossRefGoogle Scholar
  107. 107.
    McLean JM (1957) Management of the primary glaucomas. Am J Ophthalmol 44:323–334PubMedGoogle Scholar
  108. 108.
    McLean JM, Ray BS (1947) Soft glaucoma and calcificaton of the internal carotid arteris. Ach Ophthalmol 38:154ffCrossRefGoogle Scholar
  109. 109.
    Meyer J (1928) Un cas d’atrophie du nerf optique avec excavation et sans hypertension. Arch Ophthalmol (Paris) 45:46Google Scholar
  110. 110.
    Miller KM, Quigley HA (1988) The clinical appearance of the lamina cribrosa as a function of the extent of glaucomatous optic nerve damage. Ophthalmology 95:135–138PubMedGoogle Scholar
  111. 111.
    Miller S (1972) The enigma of glaucoma simplex. Trans Ophthalmol Soc UK 92:561–584PubMedGoogle Scholar
  112. 112.
    Novack RL, Stefansson E, Hatchell DL (1990) Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo. Graefe’s Arch Clin Exp Ophthalmol 228:128–133CrossRefGoogle Scholar
  113. 113.
    Pasteur VR, Blamoutier P, Mawas L, Hamburger J (1937) Access de migraine ophtalmique suivie d’une hémorragie retinienne. Ann Med 42:132–137Google Scholar
  114. 114.
    Pearce JMS; Foster JB (1965) An investigaton of complicated migraine. Neurology 15:333–340PubMedGoogle Scholar
  115. 115.
    Phelps CD (1972) The pathogenesis of optic nerve damage in glaucoma — a review of the vascular hypothesis. In: Blodi FC (ed) Current concepts in ophthalmology. Masby, St. Louis, pp 142–161Google Scholar
  116. 116.
    Phelps CD, Corbett JS (1985) Migraine and low-tension glaucoma: a case control study. Invest Ophthalmol Vis Sci 26:1105–1108PubMedGoogle Scholar
  117. 117.
    Phelps GK, Phelps CD (1975) Blood pressure and pressure amaurosis. Invest Ophthalmol 14:237–240PubMedGoogle Scholar
  118. 118.
    Pillunat LE, Stodtmeister R, Wilmanns I, Christ T (1985) Autoregulation of ocular blood flow during changes in intraocular pressure — preliminary results. Graefe’s Arch Clin Exp Ophthalmol 223:219–223CrossRefGoogle Scholar
  119. 119.
    Pillunat LE, Stodtmeister R, Wilmanns I, Christ T (1985) New aspects in pressure tolerance of the optic nerve head. Invest Ophthalmol Vis Sci 26(ARVO Suppl):223Google Scholar
  120. 120.
    Pillunat LE, Stodtmeister R, Wilmanns I, Metzner D (1986) Effect of timolol on optic nerve head autoregulation. Ophthalmologica 193:146–153PubMedCrossRefGoogle Scholar
  121. 121.
    Pillunat LE, Stodtmeister R, Wilmanns I, Christ T (1986) Drucktoleranztest des Sehnervenkopfes bei okulärer Hypertension. Klin Monatsbl Augenheilkd 186:39–44CrossRefGoogle Scholar
  122. 122.
    Pillunat LE, Stodtmeister R, Wilmanns I (1987) Pressure compliance of the optic nerve head in low tension glaucoma. Br J Ophthalmol 71:181–187PubMedCrossRefGoogle Scholar
  123. 123.
    Pryor JS, Davies PD, Hamilton DV (1979) Blindness and malignant hypertension Lancet 11:803Google Scholar
  124. 124.
    Quigley HA, Addicks EM (1981) Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage. Arch Ophthalmol 99:137–143PubMedCrossRefGoogle Scholar
  125. 125.
    Radius RL, Gonzales M (1981) Anatomy of the lamina cribrosa in human eyes. Arch Ophthalmol 99:2159–2162PubMedCrossRefGoogle Scholar
  126. 126.
    Redslob E (1941) Glaucome sans hypertension et excavation glaucomateuse. An Oculist (Paris) 177:323–340Google Scholar
  127. 127.
    Reese AB, McGavic JS (1942) Relation of field contraction to blood pressure in chronic primary glaucoma. Arch Ophthalmol 27:845–850CrossRefGoogle Scholar
  128. 128.
    Richardson KT (1972) Diagnostic evaluation and therapeutic decision in the glaucomas. Br J Ophthalmol 56:216–222PubMedCrossRefGoogle Scholar
  129. 129.
    Robert Y, Maurer W (1984) Pallor of the optic disc in glaucoma patients with artificial hypertension. Doc Ophthalmol 57:203–214PubMedCrossRefGoogle Scholar
  130. 130.
    Robert Y, Grauwiller T, Hendrickson PH, Brunner HR (1988) Die Autoregulation der Papillengefaße und ihr Verhalten unter Halothan. Klin Monatsbl Augenheilkd 192:117–121PubMedCrossRefGoogle Scholar
  131. 131.
    Robert Y, Steiner D, Hendrickson P ( 1989) Papillary circulation dynamics in glaucoma. Graefe’s Arch Clin Exp Ophthalmol 227:436–439CrossRefGoogle Scholar
  132. 132.
    Sachsenweger R (1963) Der Einfluß des Bluthochdrucks auf die Prognose des Glaukoms. Klin Monatsbl Augenheilkd 142:625–633PubMedGoogle Scholar
  133. 133.
    Schulzer M, Drance SM, Carter C, Brooks DE, Douglas GR, Lau W (1990) Biostatistical evidence for two distinct chronic open angle glaucoma populations. Br J Ophthalmol 74:196–200PubMedCrossRefGoogle Scholar
  134. 134.
    Siegert P (1938) Die ursächliche Bedeutung einer Verkalkung oder Thrombose der Carotis interna für Funktionsstörungen des Auges. Graefe’s Arch Ophthalmol 138:798–844CrossRefGoogle Scholar
  135. 135.
    Sjogren H (1946) A study in pseudoglaucoma. (Glaucoma without hypertension) Acta Ophthalmol (Kbh) 24:239–294CrossRefGoogle Scholar
  136. 136.
    Sobanski J (1935) Der intraokulare Druck und sein Einfluß auf die Zirkulation in der Netzhaut. Klin Oczna 13:214–237Google Scholar
  137. 137.
    Sobanski J (1936) Der Augendruck und sein Einfluß auf den Blutkreislauf in der Netzhaut. Graefe’s Arch Ophthalmol 185:383–400CrossRefGoogle Scholar
  138. 138.
    Sossi N, Anderson DR (1983) Effect of elevated intraocular pressure on blood flow; occurrence in cat optic nerve head studies with iodantipyrine. I 125. Arch Ophthalmol 101:98–101PubMedCrossRefGoogle Scholar
  139. 139.
    Spaeth GL (1975) Fluorescein angiography: ist contributions towards understanding the mechanism of visual loss in glaucoma. Trans Am Ophthalmol Soc 73:491–553PubMedGoogle Scholar
  140. 140.
    Sperber GO, Bill A (1985) Blood flow and glucose consumption in optic nerve, retina and brain: effects of high intraocular pressure. Exp Eye Res 41:639–653PubMedCrossRefGoogle Scholar
  141. 141.
    Stief A (1930) Zur Histopathologie des Sehnerven bei der Arteriosklerose und bei der senilen Demenz. Z Augenheilkd 70:41–52Google Scholar
  142. 142.
    Strandgaard S (1976) Autoregulation of cerebral blood flow in hypertensive patients: the modifying influence of prolonged antihypertensive treatment on the tolerance to acute, drug-induced hypotension. Circulation 53:720–727PubMedGoogle Scholar
  143. 143.
    Strandgaard S, Olesen J, Skinhoj E, Lassen NA (1973) Autoregulation of brain circulation in severe arterial hypertension. Br Med J 1:507–510PubMedCrossRefGoogle Scholar
  144. 144.
    Strandgaard S, Jones JV, MacKenzie ET, Harper AM (1975) Upper limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circ Res 37:164–167PubMedGoogle Scholar
  145. 145.
    Strandgaard S, MacKenzie ET, Jones JV, Harper AM (1976) Studies on the cerebral circulation of the baboon in acutely induced hypertension. Stroke 7:287–290PubMedCrossRefGoogle Scholar
  146. 146.
    Taylor D, Ramsay J, Day S, Dillion M (1981) Infarction of the optic nerve head in children with accelerated hypertension. Br J Ophthalmol 65:153–160PubMedCrossRefGoogle Scholar
  147. 147.
    Thiel R (1930) Glaukom ohne Hochdruck. Ber Dtsch Ophthalmol Gesellsch 48:133–136Google Scholar
  148. 148.
    Vanderburg D, Drance SM (1966) Studies on the effects of artificially raised intraocular pressure. Am J Ophthalmol 62:1049–1063PubMedGoogle Scholar
  149. 149.
    Walker WM, Walton KW, Magnani HN, Marsters JB et al. (1976) Glaucoma and ischaemic vascular disease risk factors. Trans Ophthalmol Soc UK 96:237–240PubMedGoogle Scholar
  150. 150.
    Weekers R (1942) Le glaucome incomplet. Contribution á l’étude du glaucome sans hypertension. Ophthalmologica (Basel) 104:316–331CrossRefGoogle Scholar
  151. 151.
    Weinstein JM, Feman SS (1982) Ischemic optic neuropathy in migraine. Arch Ophthalmol 100:1097–1100PubMedCrossRefGoogle Scholar
  152. 152.
    Weinstein JM, Duckrow RB, Beard D, Brennan RW (1983) Regional optic nerve blood flow and ist autoregulation. Invest Ophthalmol Vis Sci 24:1559–1565PubMedGoogle Scholar
  153. 153.
    Weinstein P (1963) Data concerning the pseudoglaucoma. Acta Ophthalmol (Kbh) 41:275–278CrossRefGoogle Scholar
  154. 154.
    Weinstock FJ (1973) Ophthalmic hazards of hypotensive drugs. JAMA 224:1039PubMedCrossRefGoogle Scholar
  155. 155.
    Wetherill JH (1979) Blindness after treatment for malignant hypertension. Br Med J 2:550PubMedCrossRefGoogle Scholar
  156. 156.
    Winder AF, Paterson G, Miller SJH (1974) Biochemical abnormalities associated with ocular hypertension and low tension glaucoma. Trans Ophthalmol Soc UK 94:518–524PubMedGoogle Scholar
  157. 157.
    Yancey CM, Linsenmeier RA (1988) The electroretinogram and choroidal PO2 in the cat during elevated intraocular pressure. Invest Ophthalmol Vis Sci 29:700–707PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • S. S. Hayreh

There are no affiliations available

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