Abstract
A fundamental problem confronting all species of vertebrates is how to exist and survive in the face of persistent exposure to pathogenic organisms. To combat this problem a wide range of sophisticated immunological strategies have evolved. Amongst these strategies, the wide spread species distribution of a Major Histocompatibility Complex (MHC)-like structure clearly illustrates its importance and early appearance during evolution. While MHC-like genes are found in a number of marine invertebrates (Reinisch and Litman 1989), it is in vertebrates that this genetic system has evolved to play a central role in cell-mediated immunity and hence determine the ability of a species to mount an immunological defence against a wide range of pathogens.
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© 1991 Springer-Verlag Berlin Heidelberg
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Sullivan, J., Kennedy, C., Trejaut, J., Dunckley, H. (1991). Polymorphisms of the Major Histocompatibility Complex in Old and New World Primates. In: Klein, J., Klein, D. (eds) Molecular Evolution of the Major Histocompatibility Complex. NATO ASI Series, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84622-9_16
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DOI: https://doi.org/10.1007/978-3-642-84622-9_16
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