Abstract
The decade of the 1980s proved to be an important period for the development of effective methods for controlling chemotherapy-induced emesis. Separate emetic problems were identified, an enhanced understanding of the physiology of emesis came about, effective agents were found, useful doses and schedules for these agents were established, combination regimens of greater efficacy were tested, and the ability to effectively prevent emesis was markedly improved.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kris MG, Tyson LB, Gralla RJ, et al. (1983) Extrapyramidal reactions with high-dose metoclopramide. N Engl J Med 309: 433
Allen JC, Gralla RJ, Reilly C et al. (1985) Metoclopramide: dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy. J Clin Oncol 3: 1136–1141
D’Acquisto RW, Tyson LB, Gralla RJ et al. (1986) The influence of a chronic high alcohol intake on chemotherapy-induced nausea and vomiting. Proc Am Soc Clin Oncol 5: 257
Sullivan JR, Leyden MJ, Bell R (1983) Decreased cisplatin induced nausea and vomiting with alcohol ingestion. N Engl J Med 309 (13): 796
Gralla RJ, Braun TJ, Squillante A et al. (1981) Metoclopramide: initial clinical studies of high dosage regimens in cisplatin-induced emesis. In: Poster D (ed) The treatment of nausea and vomiting induced by cancer chemotherapy. Masson, New York, pp 167–176
Roila F, Tonato M, Basurto C, et al. (1989) Protection from nausea and vomiting in cisplatin-treated patients: high-dose metoclopramide combined with methylprednisolone versus metoclopramide combined with dexamethasone and diphenhydramine: a study of the Italian Oncology Group for Clinical Research. J Clin Oncol 7: 1693–1700
Fetting JH, Grochow LB, Folstein MF et al. (1982) The course of nausea and vomiting after high-dose cyclophosphamide. Cancer Treat Rep 66: 1487–1493
Mangioni C, Bolls G, Pecorelli et al. (1989) Randomized trial in advanced cancer comparing cisplatin and carboplatin. J Natl Cancer Inst 81: 1464–1471
Borison HL, McCarthy LE (1983) Neuropharmacology of chemotherapy induced emesis. Drugs 25: 8–17
Fozard JR: (1984) Neuronal 5-HT receptors in the periphery. Neuropharmacology 23: 1473–1486
Meyer BR, Lewin M, Dreyer DE et al. (1984) Optimizing metoclopramide control of cisplatin-induced emesis. Ann Intern Med 100: 393–395
Gralla RJ, Itri LM, Pisko DE et al. (1981) Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med 305: 905–909
Gralla RJ, Tyson LB, Borden LB et al. (1984) Antiemetic therapy: a review of recent studies and a report of a random assignment trial comparing metoclopramide with delta-9-tetrahydrocannabinol. Cancer Treat Rep 68: 163–172
Frustaci S, Tumolo S, Tirell U et al. (1983) High-dose metoclopramide versus dexamethasone in the prevention of cisplatin induced vomiting. Proc Am Soc Clin Oncol 2: 87
Aapro MS, Plezia PM, Alberts DS et al. (1983) Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone vs high-dose metoclopramide. Proc Am Soc Clin Oncol 2: 93
Grunberg SM, Gala KV, Lampenfeld M et al. (1984) Comparison of the antiemetic effect of high-dose intravenous metoclopramide and high-dose intravenous haloperidol in a randomized double-blind crossover study. J Clin Oncol 2: 782–787
Richards PD, Flaum MA, Bateman M et al. (1986) The antiemetic efficacy of secobarbital and promazine compared to metoclopramide, diphenhydramine, and dexamethasone. A randomized trial. Cancer 58: 959–962
Strum SB, McDermed JE, Opfell RW et al. (1982) Intravenous metoclopramide. An effective antiemetic in cancer chemotherapy. JAMA 247: 2683–2686
Tyson LB, Clark RA, Gralla RJ (1982) High-dose metoclopramide; control of dacarbazine-induced emesis in a preliminary trial. Cancer Treat Rep 66: 2108
Gralla RJ, Tyson LB, Çlark RA et al. (1985) An all oral combination antiemetic regimen of patients receiving cytoxan + adriamycin + vincristine ( CAV ). Proc Am Soc Clin Oncol 4: 267
Anthony LB, Krozely MG, Woodward NJ et al. (1986) Antiemetic effect of oral versus intravenous metoclopramide in patients receiving cisplatin: a randomized double-blind trial. J Clin Oncol 4: 98–103
Garnick MB (1983) Oral metoclopramide and cisplatin chemotherapy. Ann Intern Med 99: 127
Clark RA, Gralla RJ, Kris MG, et al. (1989) Exploring very high doses of metoclopramide (4–6 mg/kg): preservation of efficacy and safety with only a single dose in a combination antiemetic regimen. Proc Am Soc Clin Oncol 8: 330
Von Hoff DD, Schilsky R, Reichert CM et al. (1979) Toxic effects of cisdichlorodiamineplatinum ( II) in man. Cancer Treat Rep 63: 1527–1531
Grossman B, Lessin LS, Cohen P (1979) Droperidol prevents nausea and vomiting from cis-platinum. N Engl J Med 301: 47
Neidhart J, Gayden M, Metz E (1980) Haldol is an effective antiemetic for platinum and mustard induced vomiting when other agents fail. Proc Am Soc Clin Oncol 21: 365
Wampler G (1983) The pharmacology and clinical effectiveness of phenothiazines and related drugs for managing chemotherapy-induced emesis. Drugs 25: 35–51
Markman M, Sheidler V, Ettinger DS et al. (1984) Antiemetic efficacy of dexamethasone. Randomized, double-blind, crossover study with prochlorperazine in patients receiving cancer chemotherapy. N Engl J Med 311: 549–552
Frytak S, Moertel CG, O’Fallon J et al. (1979) Delta-9-tetrahydrocannabinol as an antiemetic in patients treated with cancer chemotherapy: a double comparison with prochlorperazine and a placebo. Ann Intern Med 91: 825–830
Sallan SE, Cronin CM, Zelen M et al. (1980) Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. N Engl J Med 302: 135–138
Orr LE, McKerman JF, Bloone B (1980) Antiemetic effect of tetrahydrocannabinol. Arch Intern Med 140: 1431–1433
Carr BI, Bertrand M, Browning S et al. (1985) A comparison of the antiemetic efficacy of prochlorperazine and metoclopramide for the treatment of cisplatininduced emesis: a prospective randomized double-blind study. J Clin Oncol 3: 1127–1132
Aapro MS, Alberts DS (1981) High-dose dexamethasone for prevention of cis-platinum induced vomiting. Cancer Chemother Pharmacol 7: 11–14
Lee BJ (1981) Methylprednisolone as an antiemetic. N Engl J Med 3034: 486
Cassileth PA, Lusk EJ, Torri S et al. (1983) Antiemetic efficacy of dexamethasone therapy in patients receiving cancer chemotherapy. Arch Intern Med 143: 13471349
Kris MG, Gralla RJ, Tyson LB et al. (1985) Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients. Cancer 55: 527–534
Kris MG, Gralla RJ, Clark RA et al. (1987) Antiemetic control and prevention of side effects of anti-cancer therapy with lorazepam or diphenhydramine when used in combination with metoclopramide plus dexamethasone. A double-blind, randomized trial. Cancer 60: 2816–2822
Laszlo J, Clark RA, Hanson DC et al. (1985) Lorazepam in cancer patients treated with cisplatin: a drug with antiemetic amnestic and anxiolytic effects. J Clin Oncol 3: 864–869
Vincent BJ, McQuistion DJ, Einhorn LH et al. (1983) Review of cannabinoids and their antiemetic effectiveness. Drugs 25: 52–62
Tyson LB, Gralla RJ, Clark RA et al. (1985) Phase I trial of levonantradol in chemotherapy-induced emesis. Am J Clin Oncol 8: 528–532
Herman TS, Einhorn LH, Jones SE (1979) Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. N Engl J Med 300: 1295–1297
Steele N, Gralla RJ, Braun DW Jr (1980) Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis. Cancer Treat Rep 64: 219–224
Chang AE, Shiling DJ, Stillman RC et al. (1979) Delta-9-tetrahydrocannabinol as an antiemetic in patients receiving high-dose methotrexate: a prospective randomized evaluation. Ann Intern Med 91: 819–824
Venner P, Bruera E, Drebit D et al. (1986) Intensive treatment of scheduling of nabilone (N) plus dexamethasone (DM) vs. metoclopramide (M) plus DM in cisplatinum ( CP)-induced emesis. Proc Am Soc Clin Oncol 5: 253
Allan SG, Cornbleet MA, Warrington PS et al. (1984) Dexamethasone and high-dose metoclopramide: efficacy in controlling cisplatin-induced nausea and vomiting. Br Med J 289: 878–879
Rosell R, Abad-Esteve A, Ribas-Mundo M et al. (1985) Evaluation of a combination antiemetic regimen including IV high-dose metoclopramide, dexamethasone, and diphenhydramine in cisplatin-based chemotherapy regimens. Cancer Treat Rep 69: 909–910
Mason BA, Dambra J, Grossman B et al. (1982) Effective control of cisplatininduced nausea using high-dose steroids and droperidol. Cancer Treat Rep 66: 243–245
Cunningham D, Popic A, Ford I et al. (1987) Prevention of emesis in patients receiving cytotoxic drugs by GR38032F, a selective 5-HT3 receptor antagonist. Lancet: 1461–1462
Kris MG, Gralla RJ, Clark RA et al. (1988) Dose-ranging evaluation of the serotonin antagonist GR-C507/75 (GR38032F) when used as an antiemetic in patients receiving anticancer chemotherapy. J Clin Oncol 6: 659–662
Addelman M, Erlichman C, Fine S et al. (1990) Phase I/II trial of granisetron: a novel 5-hydroxytryptamine antagonist for the prevention of chemotherapy-induced nausea and vomiting. J Clin Oncol 8: 337–341
Joss R, Rohrback D, Pirovino M et al. (1988) BRL 43694: a novel antiemetic to prevent chemotherapy (CT)-induced nausea ( N) and vomiting (V ). Lung Cancer 4: A181
Tyson LR, Gralla RJ, Kris MG et al. (1989) Phase I antiemetic study of the serotonin antagonist ICS 205–930. Proc Am Soc Clin Oncol 8: 331
Stamatakis L, Michel J, Van Belle Set al. (1989) ICS 205–930: a dose finding study in the prevention of cisplatin induced nausea and vomiting. Proc Am Soc Clin Oncol 8: 327
Smaldone L, Fairchild C, Rozencweig M et al. (1988) Dose-range evaluation of BMY-25801, a non-dopaminergic antiemetic. Proc Am Soc Clin Oncol 7: 280
Wilcox PM, Fetting JH, Nettesheim KM et al. (1982) Anticipatory vomiting in women receiving cyclophosphamide, methotrexate and 5-FU ( CMF) adjuvant chemotherapy for breast carcinoma. Cancer Treat Rep 66: 1601–1604
Morrow GR (1982) Prevalence and correlates of anticipatory nausea and vomiting in chemotherapy patients. J Natl Cancer Inst 68: 585–588
Morrow GR, Morrel C (1982) Behavioral treatment for the anticipatory nausea and vomiting induced by cancer chemotherapy. N Engl J Med 307: 1476–1480
Kris MG, Gralla RJ, Clark RA et al. (1985) Incidence, course, and severity of delayed nausea and vomiting following the administration of high-dose cisplatin. J Clin Oncol 3: 1379–1384
Strum S, McDermed J, Abrahano-Umali R et al. (1985) Management of cisplatin (DDP)-induced delayed-onset nausea (N) and vomiting (V): preliminary results with two drug regimens. Proc Am Soc Clin Oncol 4: 263
Kris MG, Gralla RJ, Tyson LB et al. (1989) Controlling delayed vomiting: double-blind randomized trial comparing placebo, dexamethasone alone and metoclopramide plus dexamethasone in patients receiving cisplatin. J Clin Oncol 7: 108–114
Gralla RJ, Kris MG, Tyson LB, Clark RA (1988) Controlling emesis in patients receiving cancer chemotherapy. In: Senn HJ, Glaus A, Schmid L (eds) Supportive care in cancer patients. Springer, Berlin Heidelberg New York, pp 89–101
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Gralla, R.J. (1991). Controlling Emesis in Patients Receiving Cancer Chemotherapy. In: Senn, HJ., Glaus, A. (eds) Supportive Care in Cancer Patients II. Recent Results in Cancer Research, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84138-5_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-84138-5_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-84140-8
Online ISBN: 978-3-642-84138-5
eBook Packages: Springer Book Archive