Abstract
Over the past several years, the appropriate use of antiemetics has increased, as has the ability to control chemotherapy-associated nausea and vomiting. With greater use of chemotherapy and with the development of newer agents in which emesis is a major side-effect, the need for improved control of nausea and vomiting has become an important consideration in medical oncology and in supportive care. The primary objective of this paper is to provide a practical guide that discusses some of the major issues in the antiemetic approach to the patient receiving chemotherapy.
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References
Kris MG, Tyson LB, Gralla RJ, et al. (1983) Extrapyramidal reactions with high-dose metoclopramide. N Engl J Med 309: 433
Allen JC, Gralla RI, Reilly C et al. (1985) Metoclopramide: dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy. J Clin Oncol 3: 1136–1141
D’Acquisto RW, Tyson LB, Gralla RJ et al. (1986) The influence of a chronic high alcohol intake on chemotherapy-induced nausea and vomiting. Proc Am Soc Clin Oncol 5: 257
Sullivan JR, Leyden MJ, Bell R (1983) Decreased cisplatin induced nausea and vomiting with alcohol ingestion. N Engl J Med 309 (13): 796
Gralla RJ, Braun TJ, Squillante A et al. (1981) Metoclopramide: initial clinical studies of Controlling Emesis in Patients Receiving Cancer Chemotherapy 99 high dosage regimens in cisplatin-induced emesis. In: Poster D (ed) The treatment of nausea and vomiting induced by cancer chemotherapy. Masson, New York, pp 167–176
Fetting JH, Grochow LB, Folstein MF et al. (1982) The course of nausea and vomiting after high-dose cyclophosphamide. Cancer Treat Rep 66: 1487–1493
Borison HL, McCarthy LE (1983) Neuropharmacology of chemotherapy induced emesis. Drugs 25: 8–17
Meyer BR, Lewin M, Dreyer DE et al. (1984) Optimizing metoclopramide control of cisplatin-induced emesis. Ann Intern Med 100: 393–395
Gralla RJ, Itri LM, Pisko DE et al. (1981) Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochloperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med 305: 905–909
Gralla RJ, Tyson LB, Borden LB et al. (1984) Antiemetic therapy: a review of recent studies and a report of a random assignment trial comparing metoclopramide with delta-9-tetrahydrocannabinol. Cancer Treat Rep 68: 163–172
Frustaci S, Tumolo S, Tirell U et al. (1983) High-dose metoclopramide versus dexamethasone in the prevention of cisplatin induced vomiting. Proc ASCO 2: 87
Aapro MS, Plezia PM, Alberts DS et al. (1983) Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone vs high-dose metoclopramide. Proc. ASCO 2: 93
Grunberg SM, Gala KV, Lampenfeld M et al. (1984) Comparison of the antiemetic effect of high-dose intravenous metoclopramide and high-dose intravenous haloperidol in a randomized double-blind crossover study. J Clin Oncol 2: 782–787
Richards PD, Raum MA, Batemen M et al. (1986) The antiemetic efficacy of secobarbital and promazine compared to metoclopramide, diphenhydramine, and dexamethasone. A randomized trial. Cancer 58: 959–962
Strum SB, McDermed JE, Opfell RW et al. (1982) Intravenous metoclopramide. An effective antiemetic in cancer chemotherapy. JAMA 247: 2683–2686
Tyson LB, Clark RA, and Gralla RJ (1982) High-dose metoclopramide; control of dacarbazine-induced emesis in a preliminary trial. Cancer Treat Rep 66: 2108
Gralla RI, Tyson LB, Clark RA et al. (1985) An all oral combination antiemetic regimen of patients receiving cytoxan + adriamycin +vincristine (CAV). Proc Am Soc Clin Oncol 4: 267
Anthony LB, Krozely MG, Woodward NJ et al. (1986) Antiemetic effect of oral versus intravenous metoclopramide in patients receiving cisplatin: a randomized double-blind trial. J Clin Oncol 4: 98–103
Garnick MB (1983) Oral metoclopramide and cisplatin chemotherapy. Ann Intern Med 99: 127
Von Hoff DD, Schilsky R, Reichert CM et al. (1979) Toxic effects of cis-dichlorodiamineplatinum ( II) in man. Cancer Treat Rep 63: 1527–1531
Grossman B, Lessin LS, and Cohen P (1979) Droperidol prevents nausea and vomiting from cis-platinum. N Engl J Med 301: 47
Neidhart J, Gayen M, and Metz E (1980) Haldol is an effective antiemetic for platinum and mustard induced vomiting when other agents fail. ProcASCO 21: 365
Wampler G (1983) The pharmacology and clinical effectiveness of phenothiazines and related drugs for managing chemotherapy-induced emesis. Drugs 25: 35–51
Markman M, Sheidler V, Ettinger DS et al. (1984) Antiemetic efficacy of dexamethasone. Randomized, double-blind, crossover study with prochlorperazine in patients receiving cancer chemotherapy. N Engl J Med 311: 549–552
Frytak S, Moertel CG, O’Fallon J et al. (1979) Delta-9-tetrahydrocannabinol as an antiemetic in patients treated with cancer chemotherapy: a double comparison with prochlorperazine and a placebo. Ann Intern Med 91: 825–830
Sallan SE, Cronin CM, Zelen M et al. (1980) Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. N Engl J Med 302: 135–138
Orr LE, McKerman JF, Bloone B (1980) Antiemetic effect of tetrahydrocannabinol. Arch Intern Med 140: 1431–1433
Can BI, Bertrand M, Browning S et al. (1985) A comparison of the antiemetic efficacy of prochlorperazine and metoclopramide for the treatment of cisplatin-induced emesis: a prospective randomized double-blind study. J Clin Oncol 3: 1127–1132
Aapro MS, and Alberts DS (1981) High-dose dexamethasone for prevention of cisplatinum induced vomiting. Cancer Chemother Pharmacol 7: 11–14
Lee BJ (1981) Methylprednisolone as an antiemetic. N Engl J Med 3034: 486
Cassileth PA, Lusk EJ, Torri S et al. (1983) Antiemetic efficacy of dexamethasone therapy in patients receiving cancer chemotherapy. Arch Intern Med 143: 1347–1349
Kris MG, Gralla RJ, Tyson LB et al. (1985) Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of methoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients. Cancer 55: 527–534
Kris M, Clark R, Gralla R et al. (1986) Randomized double-blind antiemetic (AE) trial comparing combinations of metoclopramide, dexamethasone and lorazepam (MDL) in 120 patients (PTS) receiving cisplatin (DDP). Proc Am Soc Clin Oncol 5: 251
Laszlo J, Clark RA, Hanson DC et al. (1985) Lorazepam in cancer patients treated with cisplatin: a drug with antiemetic amnestic and anxiolytic effects. J Clin Oncol 3: 864–869
Vincent BJ, McQuistion DJ, Einhorn LH et al. (1983) Review of cannabinoids and their antiemetic effectiveness. Drugs 25: 52–62
Tyson LB, Gralla RI, Clark RA et al. (1985) Phase I trial of levonantradol in chemotherapy-induced emesis. Am J Clin Oncol 8: 528–532
Herman TS, Einhorn LH and Jones SE (1979) Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. N Engl J Med 300: 1295–1297
Steele N, Gralla RJ, Braun DW Jr (1980) Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis. Cancer Treat Rep 64: 219–224
Chang AE, Shiling DJ, Stillman RC et al. (1979) Delta-9-tetrahydrocannabinol as an antiemetic in patients receiving high-dose methotrexate: a prospective randomized evaluation. Ann Intern Med 91: 819–824
Venner P, Bruera E, Drebit D et al. (1986) Intensive treatment scheduling of nabilone (N) plus dexamethasone (DM) vs. methoclopramide (M) plus DM in cisplatinum (CP)-induced emesis. Proc Am Soc Clin Oncol. 5: 253
Allan SG, Cornbleet MA, Warrington PS et al. (1984) Dexamethasone and high-dose metoclopramide: efficacy in controlling cisplatin-induced nausea and vomiting. Br Med J 289: 878–879
Rosell R, Abad-Esteve A, Ribas-Mundo M et al. (1985) Evaluation of a combination antiemetic regimen including IV high-dose metoclopramide, dexamethasone, and diphenhydramine in cisplatin-based chemotherapy regimens. Cancer Treat Rep 69: 909–910
Roila F, Tonato M, Basurto C et al. (1986) Antiemetic activity of high doses of metoclopramide (MTC) combined with methylprednisolone (P) vs. MTh alone in cisplatin treated cancer patients (PTS). A randomized double blind trial of the Italian Oncology Group for Clinical Research ( GOIRC ). Proc Am Soc Clin Oncol 5: 263
Mason BA, Dambra J, Grossman B et al. (1982) Effective control of cisplatin-induced nausea using high-dose steroids and droperidol. Cancer Treat Rep 66: 243–245
Wilcox PM, Fetting JH, Nettesheim KM et al. (1982) Anticipatory vomiting in women receiving cyclophosphamide, methotrexate and 5-FU ( CMF) adjuvant chemotherapy for breast carcinoma. Cancer Treat Rep 66: 1601–1604
Morrow GR (1982) Prevalence and correlates of anticipatory nausea and vomiting in chemotherapy patients. JNCI 68: 585–588
Morrow GR, Morrell C (1982) Behavioral treatment for the anticipatory nausea and vomiting induced by cancer chemotherapy. N Engl J Med 307: 1476–1480
Kris MG, Gralla RJ, Clark RA et al. (1985) Incidence, course, and severity of delayed nausea and vomiting following the administration of high-dose cisplatin. J Clin Oncol 3: 1379–1384
Strum S, McDermed J, Abrahano-Umali R et al. (1985) Management of cisplatin (DDP)-induced delayed-onset nausea (N) and vomiting (V): preliminary results with two drug regimens. Proc Am Soc Clin Oncol 4: 263
Clark R, Kris M, Tyson L et al. (1986) Antiemetic (AE) trials to control delayed vomiting (V) following high-dose cisplatin (DDP). Proc Am Soc Clin Oncol 5: 257
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© 1988 Springer-Verlag Berlin·Heidelberg
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Gralla, R.J., Kris, M.G., Tyson, L.B., Clark, R.A. (1988). Controlling Emesis in Patients Receiving Cancer Chemotherapy. In: Senn, HJ., Glaus, A., Schmid, L. (eds) Supportive Care in Cancer Patients. Recent Results in Cancer Research, vol 108. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82932-1_12
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DOI: https://doi.org/10.1007/978-3-642-82932-1_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-82934-5
Online ISBN: 978-3-642-82932-1
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