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Significant Reduction of Faecal Endotoxin Pool by Oral Polymyxin E and Tobramycin in Human Volunteers

  • J. J. M. van Saene
  • C. P. Stoutenbeek
  • H. K. F. van Saene
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 7)

Abstract

Healthy human volunteers carry a large amount of endotoxin in their intestines (a mean of 109 pg per gram of faeces) [1]. The controlling mechanisms preventing the occurrence of systemic endotoxaemia must be extremely effective, as even such small concentrations as 2–5 ng/kg of endotoxin in blood can cause fever, thrombocytopenia etc. The first barrier constituting this important control mechanism is an intact mucosal lining, through which leakage is minimal [2]. The second barrier is the liver; intestinal endotoxin which passes the intestinal mucosa (portal endotoxaemia) is effectively cleared by Kupffer cells in the liver [3]. Finally, the third line of defence against endotoxin is the endotoxin-binding properties of the blood which neutralize endotoxin following spillover of the liver [4].

Keywords

Haemorrhagic Shock Endotoxin Concentration Limulus Amoebocyte Lysate Inventory Sample Limulus Amoebocyte Lysate Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. J. M. van Saene
  • C. P. Stoutenbeek
  • H. K. F. van Saene

There are no affiliations available

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