Significant Reduction of Faecal Endotoxin Pool by Oral Polymyxin E and Tobramycin in Human Volunteers
Healthy human volunteers carry a large amount of endotoxin in their intestines (a mean of 109 pg per gram of faeces) . The controlling mechanisms preventing the occurrence of systemic endotoxaemia must be extremely effective, as even such small concentrations as 2–5 ng/kg of endotoxin in blood can cause fever, thrombocytopenia etc. The first barrier constituting this important control mechanism is an intact mucosal lining, through which leakage is minimal . The second barrier is the liver; intestinal endotoxin which passes the intestinal mucosa (portal endotoxaemia) is effectively cleared by Kupffer cells in the liver . Finally, the third line of defence against endotoxin is the endotoxin-binding properties of the blood which neutralize endotoxin following spillover of the liver .
KeywordsPermeability Vortex Agar Foam Thrombocytopenia
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