Abstract
Rappaport in 1966 [10] introduced the term “malignant histiocytosis” to describe a disorder of “systemic, progressive, invasive proliferation of atypical histiocytes.” An identical disorder was observed by Scott and Robb-Smith in 1939 [11] and termed “histiocytic medullary reticulosis.” The most conspicuous clinical features of this disorder are enlargement of lymph nodes, liver, and spleen, and widespread multifocal involvement of the lymphatic and reticulohistiocytic system during the early phase of the disease. In the last 3 years clinical findings and therapeutic results were published [1, 6, 7, 14] and will be presented and discussed in the following.
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References
Alexander M, Daniels JR (1977) Chemotherapy of malignant histiocytosis in adults. Cancer 39: 1011–1017
Bagley CM Jr, DeVita VT Jr, Berard CW, Canellos GP (1972) Advanced lymphosarcoma: Intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone. Ann Intern Med 76: 227
Bonadonna G, De Lena M, Monfardini S, Rossi A, Brambilla C, Uslenghi C, Zucali R (1975) Combination usage of adriamycin (NSC-123127) in malignant lymphomas. Cancer Chemother Rep 6: 381
DeVita VT Jr, Serpick AA, Carbone PP (1970) Combination chemotherapy in the treatment of advanced Hodgkin’s disease. Ann Intern Med 73: 881–895
Huhn D, Meister P (1978) Malignant histiocytosis. Morphologic and cytochemical findings. Cancer 42: 1341–1349
Huhn D, Meister P, Wilmanns W (1980) Malignant histiocytosis. Clinical findings and therapy. Klin Wochenschr 58: 31–35
Lampert IA, Catovsky D, Bergier N (1978) Malignant histiocytosis: A clinicopathological study of 12 cases. Br J Haematol 40: 65–77
Lau B, Jäger G, Thiel E, Rodt H, Huhn D, Pachmann K, Netzel B, Böning L, Thierfelder S, Dormer P (1979) Growth of the Reh cell line in diffusion chambers. Evidence for differentiation along the T- and B-cell pathway. Scand J Haematol 23: 285–292
Meister P, Huhn D, Nathrath W (1980) Malignant histiocytosis. Immunohistochemical characterization on paraffin embedded tissue. Virchows Arch [Pathol Anat] 385: 233–246
Rappaport H (ed) (1966) Tumors of the hematopoietic system. Armed Forces Institute ofPathology, Washington. Atlas of tumor pathology, Sect 3, fase 8, pp 49–63
Scott RB, Robb-Smith AHT (1939) Histiocytic medullary reticulosis. Lancet 2: 194
Vardiman JW, Byrne GE Jr, Rappaport H (1975) Malignant histiocytosis with massive splenome galy in asymptomatic patients. Cancer 36: 419–427
Wilmanns W, Wilms K, Koos T (1976) Langzeitremissionen bei fortgeschrittenen Stadien der Lymphogranulomatose nach kombinierter Chemotherapie mit einem modifizierten de Vita-Schema. Lehmann, Munich (Hämatologie und Bluttransfusion, vol 18)
Zucker JM, Caillaux JM, Vanel D, Gerard-Marchant R (1980) Malignant histiocytosis in childhood. Clinical study and therapeutic results in 22 cases. Cancer 45: 2821–2829
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© 1981 Springer-Verlag Berlin Heidelberg New York
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Huhn, D. (1981). Therapy of Malignant Histiocytosis. In: Schmalzl, F., Huhn, D., Schaefer, H.E. (eds) Disorders of the Monocyte Macrophage System. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81696-3_24
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DOI: https://doi.org/10.1007/978-3-642-81696-3_24
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