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Immunological Consequences of Antibiotic Therapy

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Immunology and Its Impact on Infections in Surgery

Abstract

Antibiotics may interfere with host defense in many ways. They may impact bacterial toxin release and thus alter the response of the host to bacterial challenge including endo- and exotoxinemia. They may also alter the release of various proinflammatory mediators and influence the complex system of immune defense. Antibiotics may alter the action of complement and immunoglobulins. They may interfere with phagocytosis and intracellular killing of bacteria by neutrophils and macrophages, alter monocyte and lymphocyte function, and influence delayed-type hypersensitivity and antibody production. There are reports which also show that antibiotics interfere with allograft rejection in transplant surgery.

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Authors
  1. D. H. Wittmann
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Editors and Affiliations

  1. Chirurgische Universitäts- und Poliklinik, Universität Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    Rainer Engemann , Rene Holzheimer  & A. Thiede ,  & 

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© 1995 Springer-Verlag Berlin Heidelberg

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Wittmann, D.H. (1995). Immunological Consequences of Antibiotic Therapy. In: Engemann, R., Holzheimer, R., Thiede, A. (eds) Immunology and Its Impact on Infections in Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79079-9_31

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  • DOI: https://doi.org/10.1007/978-3-642-79079-9_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58145-1

  • Online ISBN: 978-3-642-79079-9

  • eBook Packages: Springer Book Archive

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