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Effects of cefodizime and cefotaxime on cellular and humoral immune responses

Wirkung von Cefodizim und Cefotaxim auf die zelluläre und humorale Immunantwort

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Summary

Cefodizime is a new cephalosporin antibiotic which has shown some remarkable immunomodulating activities. To mimic possible immunopharmacological effects of prolonged chemotherapyin vivo, we investigated the influence of a seven-day treatment with cefodizime on cellular and humoral parameters of the immune system in BALB/c mice. The dosages (0.4, 0.8 and 1.8 mg cefodizime per day) were calculated on a per kg bodyweight basis according to therapy recommendations for humans. Delayed type hypersensitivity (oxazolone test) as well as the production of IgM and IgG antibodies (direct and indirect plaque forming test) were investigated in BALB/c mice. Leukocyte and monocyte activities were measured using human cells. The results are discussed using cefotaxime as comparable reference drug.

Zusammenfassung

Cefodizim ist ein neues Cephalosporin- Antibiotikum, das bemerkenswerte immunmodulierende Eigenschaften besitzt. Im BALB/c-Mäuse-Modell wurdenin vivo die Auswirkungen einer sieben-tägigen Chemotherapie mit dem neuen Cephalosporin-Präparat Cefodizim im Vergleich mit Cefotaxim hinsichtlich der spezifischen humoralen und zellulären Immunantwort getestet. Die verwendeten Dosierungen wurden an Hand der therapeutischen Dosierungen beim Menschen auf Körpergewichtsbasis kalkuliert. Im Unterschied zu Cefotaxim beeinflußte die Cefodizim-Therapie weder die Produktion von Immunglobulinen (IgM und IgG) noch die zelluläre Immunantwort (Oxazolon- Test).In vitro zeigten beide Cephalosporin-Präparate keine Beeinflussung der Phagozytoseaktivität, der Chemotaxis und der intrazellulären Bakterienabtötung durch menschliche Granulozyten und Monozyten.

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  1. Institut für Medizinische Mikrobiologie und Hygiene der Universität zu Köln, Goldenfelsstr. 19–21, W-5000, Köln 41, Germany

    G. Pulverer

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  1. G. Pulverer
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Pulverer, G. Effects of cefodizime and cefotaxime on cellular and humoral immune responses. Infection 20 (Suppl 1), S41–S44 (1992). https://doi.org/10.1007/BF01709950

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