Abstract
Proteins and lipids co-exist in biomembranes as a functioning and dynamic entity. Both spin-label electron spin resonance and solid state nuclear magnetic resonance methods have been used to quantitate the mutual interactions between proteins and lipids in both reconstituted and natural membranes. The information available from these methods includes the stoichiometry of the lipid-protein interaction which can be used to make estimates about the protein hydrophobic surface area, and hence protein size. Both the exchange rates of lipids into and out of the protein-lipid interface, as well as any selectivity of lipid-protein associations, has been determined for a number (>15) of integral membrane proteins. Such physical properties do have functional significance in many cases.
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References
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© 1994 Springer-Verlag Berlin Heidelberg
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Watts, A. (1994). Magnetic Resonance Studies of Protein-Lipid Interactions. In: Op den Kamp, J.A.F. (eds) Biological Membranes: Structure, Biogenesis and Dynamics. NATO ASI Series, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78846-8_8
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DOI: https://doi.org/10.1007/978-3-642-78846-8_8
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