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Acyl Glucuronides as Chemically Reactive Intermediates

  • Chapter
Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 112))

Abstract

Virtually all types of xenobiotic acids form 1-O-acyl glucuronides. Many other xenobiotic compounds are metabolized to carboxylic acids, which subsequently undergo phase II conjugation with glucuronic acid. Often such a conjugate constitutes the major metabolite. Many examples are found among the hypolipidemic agents, diuretic agents, and nonsteroidal anti-inflammatory drugs. Most herbicides are metabolized in this manner by fish, birds and mammals. 1-O-Acyl glucuronides are also formed from endogenous lipids such as retinoic acid, lithocholic acid and bilirubin. The major site of conjugation in humans is the liver. 1-O-Acyl glucuronides are excreted through the bile duct and the kidney, and many of these conjugates have been shown to circulate in plasma.

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  1. C. Fenselau
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  1. Laboratory for Cellular and Biochemical Toxicology College of Pharmacy, Rutgers University, Kilmer Campus 41 Gordon Road, Piscataway, NJ, 08854, USA

    Frederick C. Kauffman Ph.D. (Director) (Director)

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Fenselau, C. (1994). Acyl Glucuronides as Chemically Reactive Intermediates. In: Kauffman, F.C. (eds) Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity. Handbook of Experimental Pharmacology, vol 112. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78429-3_13

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  • DOI: https://doi.org/10.1007/978-3-642-78429-3_13

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