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Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

  • Frederick C. Kauffman

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 112)

Table of contents

  1. Front Matter
    Pages I-XXIV
  2. Transferases and Hydrolases Involved in Phase II Conjugation—Deconjugation Reactions, Genetic Polymorphism and Regulation of Expression

    1. Front Matter
      Pages 1-1
    2. R. Weinshilboum, D. Otterness
      Pages 45-78
    3. K. P. Vatsis, W. W. Weber
      Pages 109-130
    4. C. R. Creveling, D. R. Thakker
      Pages 189-216
  3. Regulation of Phase II Conjugation: Deconjugation Reactions in Intact Cells and Tissues

  4. Pharmacology and Toxicology of Drug Conjugates

    1. Front Matter
      Pages 339-339
    2. F. C. Kauffman, J. Zaleski, R. G. Thurman, G. Y. Kwei
      Pages 341-366
    3. J. A. Miller, Y.-J. Surh
      Pages 429-457
    4. T. J. Monks, S. S. Lau
      Pages 459-509
    5. F. C. Kauffman
      Pages 511-524
  5. Back Matter
    Pages 525-530

About this book

Introduction

Advances in molecular biology describing important enzyme systems involved in drug conjugation and deconjugation reactions and recent work indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds are reviewed comprehensively. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, and Part Three reviews critically the importance of drug conjugates in pharmacology and toxicology. This volume is an up-to-date source of information on this topic and will be of broad interest to pharmacologists and toxicologists.

Keywords

Drug conjugates Konjugation Stoffwechsel Transferasen acyl-linked conjugates conjugate enzymes hydrolases metabolism regulation transferases transport

Editors and affiliations

  • Frederick C. Kauffman
    • 1
  1. 1.Laboratory for Cellular and Biochemical Toxicology College of PharmacyRutgers UniversityPiscatawayUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-78429-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1994
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-78431-6
  • Online ISBN 978-3-642-78429-3
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site