Abstract
As thrombolytic therapy developed as a potential intervention for acute ischemic stroke during the 1980s, early clinical investigation depended upon pretreatment cerebral arteriography [5]. The pathologic cerebral anatomy was first defined, and then thrombolytic therapy could be administered selectively to the site of thrombosis via the intra-arterial route [3, 6, 11]. These intra-arterial thrombolytic interventions, carried out with the benefit of computed tomographic (CT) scanning to exclude hemorrhagic stroke, demonstrated the feasibility of cerebral arterial clot lysis. Several thrombolytic agents administered in a variety of doses [3–6, 11–13] were shown to accomplish partial or complete arterial recanalization in the setting of acute cerebral embolism or thrombosis.
This work was supported in part by the National Institute of Neurological Disorders and Stroke.
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References
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Brott, T. (1993). Symptom-Based Trials of Intravenous rt-PA in Acute Stroke. In: del Zoppo, G.J., Mori, E., Hacke, W. (eds) Thrombolytic Therapy in Acute Ischemic Stroke II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78061-5_6
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DOI: https://doi.org/10.1007/978-3-642-78061-5_6
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